Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David J. Rosenman"'
Publikováno v:
Cureus
LIDAR (from "light detection and ranging" or "laser imaging, detection, and ranging") is an evolving three-dimensional scanning technology with historical applications in various fields. However, the applicability of LIDAR in the field of medicine ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf82d7b853d9cb8d772b06a1bb0a2521
http://europepmc.org/articles/PMC8416260
http://europepmc.org/articles/PMC8416260
Autor:
David J. Rosenman, Wendy Sue Swanson
Publikováno v:
Academic medicine : journal of the Association of American Medical Colleges. 95(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849b9056110286cd324d497d438920c4
https://pubmed.ncbi.nlm.nih.gov/31136341
https://pubmed.ncbi.nlm.nih.gov/31136341
Publikováno v:
Chemical communications (Cambridge, England). 54(36)
Here we present the high pressure NMR characterization of Aβ42 and two Aβ40 variants with Alzheimer-causing mutations E22G and D23N. While chemical shifts only identified localized changes at ambient pressure compared with Aβ40, high pressure NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a14cb57089e81b2f09698fffdb93cb6
https://pubmed.ncbi.nlm.nih.gov/29670961
https://pubmed.ncbi.nlm.nih.gov/29670961
Autor:
Chunyu Wang, Angel E. Garcia, David J. Rosenman, Allison S. Zwarycz, Martin J. Fossat, Zhongqian Lin, Catherine A. Royer, Kenneth V. Mills, Otar Akanyeti
Publikováno v:
Biochemistry. 56(21)
Inteins mediate protein splicing, which has found extensive applications in protein science and biotechnology. In the Mycobacterium tuberculosis RecA mini–mini intein (ΔΔIhh), a single valine to leucine substitution at position 67 (V67L) dramatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd35c0db2628c8d43287a33a3b61e80
https://pubmed.ncbi.nlm.nih.gov/28488863
https://pubmed.ncbi.nlm.nih.gov/28488863
Publikováno v:
SSRN Electronic Journal.
In the healthcare industry, it is and has traditionally been assumed that care providers, researchers and industry executives are more expert medical innovators than are patient “user innovators” – those who are themselves afflicted by medical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9443d225b2adc6fdfc4db4169714981
https://doi.org/10.2139/ssrn.2997676
https://doi.org/10.2139/ssrn.2997676
Autor:
David J. Rosenman, Patrick Van Roey, Victoria E Jones, Christopher Bystroff, Wilfredo Colón, Ke Xia, Keith Fraser, Yao-ming Huang, Colleen M Lamberson
Publikováno v:
Protein Science. 23:400-410
Wild-type green fluorescent protein (GFP) folds on a time scale of minutes. The slow step in folding is a cis-trans peptide bond isomerization. The only conserved cis-peptide bond in the native GFP structure, at P89, was remodeled by the insertion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1695a6078902a3a1dc5f1a447de6efc2
https://doi.org/10.1002/pro.2421
https://doi.org/10.1002/pro.2421
Autor:
Shivina Mittal, Dahabada H. J. Lopes, Christopher R. Connors, Georges Belfort, Mirco Sorci, David J. Rosenman, Gal Bitan, Angel Garcia, Chunyu Wang
Publikováno v:
Biochemistry. 52:3995-4002
The antiallergy and potential anticancer drug tranilast has been patented for treating Alzheimer's disease (AD), in which amyloid β-protein (Aβ) plays a key pathogenic role. We used solution NMR to determine that tranilast binds to Aβ40 monomers w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcaf59f733f3cfeef633610b525ec188
https://doi.org/10.1021/bi400426t
https://doi.org/10.1021/bi400426t
Publikováno v:
The journal of physical chemistry. B. 120(2)
Amyloid β (Aβ) monomers represent a base state in the pathways of aggregation that result in the fibrils and oligomers implicated in the pathogenesis of Alzheimer's disease (AD). The structural properties of these intrinsically disordered peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60033f422931987fa042e5b2aa7758d
https://pubmed.ncbi.nlm.nih.gov/26562747
https://pubmed.ncbi.nlm.nih.gov/26562747
Autor:
Wen Chen, Eric R. Gamache, Yueming Li, David J. Rosenman, Jian Xie, Chunyu Wang, Maria M. Lopez
Publikováno v:
Nature Communications. 5
The high Aβ42/Aβ40 production ratio is a hallmark of familial Alzheimer’s disease, which can be caused by mutations in the amyloid precursor protein (APP). The C-terminus of Aβ is generated by γ-secretase cleavage within the transmembrane domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9600f63fce84e033fc82a19e75a2ecd
https://doi.org/10.1038/ncomms4037
https://doi.org/10.1038/ncomms4037
Publikováno v:
Biophysical Journal. 106(2)
Amyloid β (Aβ) monomers represent the base state in the pathways of aggregation that result in the fibrils and oligomers involved in Alzheimer's disease (AD). The structural properties of these intrinsically disordered peptides remain unclear despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6ac127fd57073cd814672096d4f87b