Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David J. Rance"'
Publikováno v:
British Journal of Clinical Pharmacology. 53:13S-20S
Aims To characterize the absorption, metabolism and excretion of an oral and intravenous (IV) dose of radiolabelled [14C]-sildenafil citrate in healthy male subjects. Specific objectives were to measure the cumulative amount of drug-related radiolabe
Autor:
D. K. Walker, G C James, P Wastall, Gary J. Muirhead, David J. Rance, M J Ackland, P A Wright
Publikováno v:
Xenobiotica. 29:297-310
1. Pharmacokinetics were studied in mouse, rat, rabbit, dog and man after single intravenous and/or oral doses of sildenafil or [14C]-sildenafil (Viagra). 2. In man, absorption from the gastrointestinal tract was essentially complete. With the except
Publikováno v:
Life Sciences. 57:1819-1831
Several human liver UDP-Glucuronosyltransferases (UGTs) have been cloned and the cDNAs expressed in heterotogous cell lines. This technological advance has allowed the assessment of the functional substrate specificity of these UGTs. The problems whi
Publikováno v:
Archives of Biochemistry and Biophysics. 319:481-490
Partially purified aldehyde oxidase (EC 1.2.3.1) has been prepared from human, rabbit, guinea pig, and baboon liver by heat treatment and precipitation with ammonium sulfate. The interaction of 35 substituted quinazolines and phthalazines with human
Publikováno v:
Xenobiotica. 24:37-47
1. After administration of [14C]-carbazeran by oral gavage to guinea pigs, 48% of the dosed radioactivity was recovered in urine and 46% in faeces after 144 h. 2. The major urinary metabolite was identified by infrared spectroscopy and mass spectrome
Publikováno v:
Biochemical and Biophysical Research Communications. 185:54-59
Molybdenum hydroxylase activity in guinea pig liver has been compared with that of marker enzymes in mitochondria (succinate dehydrogenase), microsomes (glucose-6-phosphatase) and cytosol (lactate dehydrogenase). Aldehyde oxidase activity was highest
Autor:
Stephen J. Holland, Paul V. Fish, John P. Overington, Keith James, Stuart M. Abel, Michael J. Powling, David J. Rance, Andrew B. McElroy, Edward Hawkeswood, Alan Daniel Brown, John C. Danilewicz
Publikováno v:
Journal of medicinal chemistry. 45(12)
Potent and selective inhibitors of thrombin were sought based on the (R)-Phe-Pro-Arg sequence. The objective was to generate similar binding interactions to those achieved by potent competitive inhibitors of the argatroban type, so eliminating the ne
Autor:
Samantha Abel, Malcolm D Eve, Gerry C James, Michael J Allen, Nicholas R Scott, David J. Rance, K Ashley Milton, Vivienne C Jenkins
Publikováno v:
Journal of clinical pharmacology. 42(5)
Four separate studies were conducted to examine the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of eletriptan, a 5-HT(1B/1D) receptor agonist being developed for the treatment of migraines, after oral and intravenous admini
Publikováno v:
British journal of clinical pharmacology. 53
To characterize the absorption, metabolism and excretion of an oral and intravenous (IV) dose of radiolabelled [14C]-sildenafil citrate in healthy male subjects. Specific objectives were to measure the cumulative amount of drug-related radiolabelled
Publikováno v:
Analytical biochemistry. 255(1)
A new unified assay for the determination of UDP-glucuronosyltransferase (UGT) activities has been developed. The resolution of [14C]uridine diphosphate glucuronic acid from radiolabeled glucuronides formed by incorporation of this radiolabel can now