Zobrazeno 1 - 10
of 25
pro vyhledávání: '"David J. Pulford"'
Autor:
Jack Euesden, Sivakumar Gowrisankar, Angela Xiaoyan Qu, Pamela St. Jean, Arlene R. Hughes, David J. Pulford
Publikováno v:
Genes, Vol 11, Iss 5, p 501 (2020)
Introduction: Alzheimer’s disease (AD) is a progressive and irreversible neurological disease. The genetics and molecular mechanisms underpinning differential cognitive decline in AD are not well understood; the genetics of AD risk have been studie
Externí odkaz:
https://doaj.org/article/58741971c88648439f0f507622061ef4
Publikováno v:
Viruses, Vol 9, Iss 12, p 378 (2017)
Smallpox vaccination carries a high risk of adverse events in recipients with a variety of contra-indications for live vaccines. Although alternative non-replicating vaccines have been described in the form of replication-deficient vaccine viruses, D
Externí odkaz:
https://doaj.org/article/32168512c668412f863291e3dc50c7cf
Autor:
Piyumali K Perera, Robin B Gasser, David J Pulford, Mark A Stevenson, Simon M Firestone, Andrew M J McFadden, Abdul Jabbar
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-11 (2015)
Abstract Background Oriental theileriosis is a tick-borne disease of bovines caused by the members of the Theileria orientalis complex. Recently, we developed a multiplexed tandem (MT) PCR to detect, differentiate and quantitate four genotypes (i.e.,
Externí odkaz:
https://doaj.org/article/44426f416e1c4d8fb63941ce2f725470
Autor:
John E. Brandt, Sandra K. Prucka, Sandra Gilardi, Lester J. Arnold, Lea C. Harty, Feng Hong, David J. Pulford, Joanne Malia
Publikováno v:
Bioethics
The ease with which genotyping technologies generate tremendous amounts of data on research participants has been well chronicled, a feat that continues to become both faster and cheaper to perform. In parallel to these advances come additional ethic
Autor:
Dominique Berton-Rigaud, Myong Cheol Lim, John K. Chan, Catherine Barrett, Giovanni Scambia, G. Elser, David J. Pulford, Pauline Wimberger, Michael Friedlander, Hiroomi Tada, Dong Hoon Suh, Martin Imhof, Charles J. Cox, Toby Johnson, Andreas du Bois, Mansoor Raza Mirza, Jose Angel Arranz, Chun Fang Xu, Anne Floquet, Philipp Harter, Peter Vuylsteke, Thomas J. Herzog, Kosei Hasegawa, Paula Calvert, Nicoletta Donadello
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
BMC Medical Ethics
Consejería de Sanidad de la Comunidad de Madrid
BMC Medical Ethics
Background The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b75f7dd96c0ece4a4412fa56ca33698
https://hdl.handle.net/20.500.12530/24847
https://hdl.handle.net/20.500.12530/24847
Publikováno v:
International Journal of Food Science & Technology. 43:2143-2150
Summary The ability of small heat shock proteins (sHSP) at preventing the aggregation and precipitation of unfolded and misfolded proteins because of changes in pH and temperature is widely recognised. The performance of sHSP from bovine lens extract
Autor:
David J Pulford, A. M. J. McFadden, Piyumali K. Perera, Abdul Jabbar, Simon M. Firestone, Robin B. Gasser, Mark Stevenson
Publikováno v:
Parasites & Vectors
Background Oriental theileriosis is a tick-borne disease of bovines caused by the members of the Theileria orientalis complex. Recently, we developed a multiplexed tandem (MT) PCR to detect, differentiate and quantitate four genotypes (i.e., buffeli,
Autor:
David J Pulford, David J Mallinson, Caroline A. Stewart, Ian C. Reid, Fiona Adams, Brian Henry
Publikováno v:
Neuropsychiatric Disease and Treatment
Transthyretin (TTR) accounts for a quarter of the protein content of ventricular cerebrospinal fluid (CSF) yet its exact role in the brain remains unknown. Patients with a diagnosis of depression have reduced CSF levels of TTR and the locus encoding
Autor:
Andrew A. Wylie, David J. Pulford, Alison McVie-Wylie, Yuan-Tsong Chen, Randy L. Jirtle, Terry C. Orton, Catherine M. Nolan, Heather K. Evans, Robert A. Waterland
Publikováno v:
The American Journal of Pathology. 162:321-328
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and T cell- mediated immunity. M6P/IGF2R is an imprinted gen
Publikováno v:
Mutation Research/Reviews in Mutation Research. 436:59-67
Polymorphisms have been identified in proto-oncogenes and tumor suppressor genes that predispose people to cancer. Recent evidence indicates that genomic imprinting, an epigenetic form of gene regulation that results in uniparental gene expression, c