Zobrazeno 1 - 10
of 91
pro vyhledávání: '"David J. Picketts"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Chromatin remodeling proteins utilize the energy from ATP hydrolysis to mobilize nucleosomes often creating accessibility for transcription factors within gene regulatory elements. Aberrant chromatin remodeling has diverse effects on neuroprogenitor
Externí odkaz:
https://doaj.org/article/896b455e130e4f4ab6fa32fe3d7d320c
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Conditional ablation of the Smarca5 gene in mice severely impairs the postnatal growth of the cerebellum and causes an ataxic phenotype. Comparative gene expression studies indicated that complement-related proteins were upregulat
Externí odkaz:
https://doaj.org/article/f0efe60264d4403e974ff5c9e8051cbe
Autor:
Sara Timpano, David J. Picketts
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The ability to determine the genetic etiology of intellectual disability (ID) and neurodevelopmental disorders (NDD) has improved immensely over the last decade. One prevailing metric from these studies is the large percentage of genes encoding epige
Externí odkaz:
https://doaj.org/article/9d1f496b3ef041d48c06ca8c3ce4dc42
Autor:
Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick F. Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/23519f12f351443dabd9173f3e5f56f7
Autor:
Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.
Externí odkaz:
https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b
Correction to: C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-2 (2020)
Following publication of the original article, the authors noticed missing labels in Fig. 1a
Externí odkaz:
https://doaj.org/article/b0a2dc9dc70948bdb3aae33b5555959c
Autor:
Matías Alvarez-Saavedra, Keqin Yan, Yves De Repentigny, Lukas E. Hashem, Nidhi Chaudary, Shihab Sarwar, Doo Yang, Ilya Ioshikhes, Rashmi Kothary, Teruyoshi Hirayama, Takeshi Yagi, David J. Picketts
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Alterations in the homeostasis of either cortical progenitor pool, namely the apically located radial glial (RG) cells or the basal intermediate progenitors (IPCs) can severely impair cortical neuron production. Such changes are reflected by microcep
Externí odkaz:
https://doaj.org/article/d7220e31b12f4750869ddc345c3882b8
Autor:
Matías Alvarez-Saavedra, Yves De Repentigny, Doo Yang, Ryan W. O’Meara, Keqin Yan, Lukas E. Hashem, Lemuel Racacho, Ilya Ioshikhes, Dennis E. Bulman, Robin J. Parks, Rashmi Kothary, David J. Picketts
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 862-875 (2016)
Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain he
Externí odkaz:
https://doaj.org/article/9b6b65d29dbe477783fc4f4ada236722
Autor:
Rebekah Tillotson, Keqin Yan, Julie Ruston, Taylor de Young, Alex Córdova, Valérie Turcotte- Cardin, Yohan Yee, Christine Taylor, Shagana Visuvanathan, Christian Babbs, Evgueni A Ivakine, John G Sled, Brian J Nieman, David J Picketts, Monica J Justice
Publikováno v:
Human Molecular Genetics.
ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but its role in neurological function remains e
Publikováno v:
Hum Mol Genet
Heterozygous variants in bromodomain and plant homeodomain containing transcription factor (BPTF) cause the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL) syndrome (MIM#617755) characterized by intellectual disa