Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David J. Pedersen"'
Autor:
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112488- (2023)
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl
Externí odkaz:
https://doaj.org/article/12bc2d6551c14f2b8d253e56cdc46fc0
Autor:
Adilson Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Donald A. Morgan, Kamal Rahmouni, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 116-125 (2018)
Objective: Crosstalk between adipocytes and local neurons may be an important regulatory mechanism to control energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN
Externí odkaz:
https://doaj.org/article/15917499c6d14b8da7c28dcc88f2cde2
Autor:
Adilson Guilherme, David J. Pedersen, Elizabeth Henchey, Felipe S. Henriques, Laura V. Danai, Yuefei Shen, Batuhan Yenilmez, DaeYoung Jung, Jason K. Kim, Irfan J. Lodhi, Clay F. Semenkovich, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 781-796 (2017)
Background: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology an
Externí odkaz:
https://doaj.org/article/6bc9d2917df04eb3b86d55ef045f6e28
Autor:
David J. Pedersen, Adilson Guilherme, Laura V. Danai, Lauren Heyda, Anouch Matevossian, Jessica Cohen, Sarah M. Nicoloro, Juerg Straubhaar, Hye Lim Noh, DaeYoung Jung, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 4, Iss 7, Pp 507-518 (2015)
Objective: Adipose tissue (AT) inflammation is associated with systemic insulin resistance and hyperinsulinemia in obese rodents and humans. A longstanding concept is that hyperinsulinemia may promote systemic insulin resistance through downregulatio
Externí odkaz:
https://doaj.org/article/25dbea29984f42b69a63ebc38311b475
Autor:
David J. Pedersen
Publikováno v:
Review of Financial Economics. 39:280-289
Employees bear significant costs in bankruptcy. Theoretical models predict they will accept lower wages in the face of financial distress to avoid such costs. Using a natural experiment, I test this theory and find an exogenous increase in default ri
Publikováno v:
Financial Management. 49:615-633
Empirical research finds that stocks with low market‐to‐book (MTB) ratios outperform stocks with high MTB ratios. Rhodes‐Kropf, Robinson, and Viswanathan separate the MTB ratio into mispricing and growth options components. We report that the m
Publikováno v:
Journal of Financial and Quantitative Analysis. 54:1371-1401
Academic literature, practitioners, courts, and regulators routinely assert that both private and subsidiary targets sell at discounts relative to public targets. However, the empirical evidence to support this conclusion is thin. Our work alters the
Autor:
David J. Pedersen
Publikováno v:
Journal of Financial and Quantitative Analysis. 54:907-923
Using a natural experiment to identify the causal effect of an increase in default risk on firm actions, I find little evidence managers shift risk to corporate pension plans following an exogenous shock to the firm’s long-term liabilities. The fin
Autor:
Yuefei Shen, Michael P. Czech, Adilson L. Guilherme, Batuhan Yenilmez, Felipe Henriques, Elizabeth Henchey, Laura V. Danai, Irfan J. Lodhi, David J. Pedersen, Clay F. Semenkovich, Jason K. Kim, Dae Young Jung
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 781-796 (2017)
Molecular Metabolism
Molecular Metabolism
Background The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and
Autor:
David J. Pedersen, Adilson L. Guilherme, Robert T. Lawrence, Michael P. Czech, David A. Guertin, Su Myung Jung, Judit Villén, Sanchez-Gurmaches J, Miguel Martin-Perez, Samuel W. Entwisle
Stimulating brown adipose tissue (BAT) energy expenditure could be a therapy for obesity and related metabolic diseases. Achieving this requires a systems-level understanding of the biochemical underpinnings of thermogenesis. To identify novel metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f284a058a1e0e0f33a5416aa5060fd98
https://doi.org/10.1101/445718
https://doi.org/10.1101/445718