Zobrazeno 1 - 10
of 309
pro vyhledávání: '"David J. P. Ferguson"'
Autor:
Molly Hair, Flávia Moreira-Leite, David J. P. Ferguson, Mohammad Zeeshan, Rita Tewari, Sue Vaughan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Gametogenesis in Plasmodium spp. occurs within the Anopheles mosquito and is essential for sexual reproduction / differentiation and onwards transmission to mammalian hosts. To better understand the 3D organisation of male gametogenesis, we
Externí odkaz:
https://doaj.org/article/a3273de686f04cc5877880c533d05902
Autor:
Mohammad Zeeshan, Rajan Pandey, Amit Kumar Subudhi, David J. P. Ferguson, Gursimran Kaur, Ravish Rashpa, Raushan Nugmanova, Declan Brady, Andrew R. Bottrill, Sue Vaughan, Mathieu Brochet, Mathieu Bollen, Arnab Pain, Anthony A. Holder, David S. Guttery, Rita Tewari
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Zeeshan et al. used real-time live-cell and ultrastructural imaging, conditional gene knockdown, RNA-seq and proteomic approaches to implicate Plasmodium PP1 in both mitotic exit and, potentially, establishing cell polarity during zygote development
Externí odkaz:
https://doaj.org/article/b7773fc630264f8886ca813289e58978
Autor:
Marc-Jan Gubbels, David J. P. Ferguson, Sudeshna Saha, Julia D. Romano, Suyog Chavan, Vincent A. Primo, Cynthia Michaud, Isabelle Coppens, Klemens Engelberg
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The Apicomplexa are famously named for their apical complex, a constellation of organelles at their apical end dedicated to invasion of their host cells. In contrast, at the other end of the cell, the basal complex (BC) has been overshadowed since it
Externí odkaz:
https://doaj.org/article/b3170a7e37a44054bfd01dd5e27766ee
Autor:
Richard J. Wall, David J. P. Ferguson, Aline Freville, Blandine Franke-Fayard, Declan Brady, Mohammad Zeeshan, Andrew R. Bottrill, Sally Wheatley, Andrew M. Fry, Chris J. Janse, Hiroyuki Yamano, Anthony A. Holder, David S. Guttery, Rita Tewari
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contri
Externí odkaz:
https://doaj.org/article/c4146aca53b342b192bb9f54c10c319c
Autor:
Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, Syevda Sirenko, Katalin Pinter, Neil Herring, Julia J. Jung, Kirill V. Tarasov, Emily J. Sharpe, Markus Wolfien, Gabor Czibik, Violetta Steeples, Sahar Ghaffari, Chinh Nguyen, Alexander Stockenhuber, Joshua R. St. Clair, Christian Rimmbach, Yosuke Okamoto, Dongmei Yang, Mingyi Wang, Bruce D. Ziman, Jack M. Moen, Daniel R. Riordon, Christopher Ramirez, Manuel Paina, Joonho Lee, Jing Zhang, Ismayil Ahmet, Michael G. Matt, Yelena S. Tarasova, Dilair Baban, Natasha Sahgal, Helen Lockstone, Rathi Puliyadi, Joseph de Bono, Owen M. Siggs, John Gomes, Hannah Muskett, Mahon L. Maguire, Youlia Beglov, Matthew Kelly, Pedro P. N. dos Santos, Nicola J. Bright, Angela Woods, Katja Gehmlich, Henrik Isackson, Gillian Douglas, David J. P. Ferguson, Jürgen E. Schneider, Andrew Tinker, Olaf Wolkenhauer, Keith M. Channon, Richard J. Cornall, Eduardo B. Sternick, David J. Paterson, Charles S. Redwood, David Carling, Catherine Proenza, Robert David, Mirko Baruscotti, Dario DiFrancesco, Edward G. Lakatta, Hugh Watkins, Houman Ashrafian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2
Externí odkaz:
https://doaj.org/article/93dc1bb6f94248b0bbd5f23512479816
Autor:
Bradley I. Coleman, Sudeshna Saha, Seiko Sato, Klemens Engelberg, David J. P. Ferguson, Isabelle Coppens, Melissa B. Lodoen, Marc-Jan Gubbels
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Invasion of host cells by apicomplexan parasites such as Toxoplasma gondii is critical for their infectivity and pathogenesis. In Toxoplasma, secretion of essential egress, motility, and invasion-related proteins from microneme organelles is
Externí odkaz:
https://doaj.org/article/02ef691e1abc4316a0c22d50ae4b1d0a
Autor:
David S. Guttery, Abhinay Ramaprasad, David J. P. Ferguson, Mohammad Zeeshan, Rajan Pandey, Declan Brady, Anthony A. Holder, Arnab Pain, Rita Tewari
Publikováno v:
Cells, Vol 9, Iss 12, p 2590 (2020)
The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium. Here, we present a functional
Externí odkaz:
https://doaj.org/article/1311cbb1d3b6487baf891fba1dcd5837
Autor:
Rashmi Dubey, Brooke Harrison, Sriveny Dangoudoubiyam, Giulia Bandini, Katherine Cheng, Aziz Kosber, Carolina Agop-Nersesian, Daniel K. Howe, John Samuelson, David J. P. Ferguson, Marc-Jan Gubbels
Publikováno v:
mSphere, Vol 2, Iss 5 (2017)
ABSTRACT The inner membrane complex (IMC) of apicomplexan parasites contains a network of intermediate filament-like proteins. The 14 alveolin domain-containing IMC proteins in Toxoplasma gondii fall into different groups defined by their distinct sp
Externí odkaz:
https://doaj.org/article/42927399fafb4a71bb9dae7a12a49fc4
Autor:
Benoit Poulin, Eva-Maria Patzewitz, Declan Brady, Olivier Silvie, Megan H. Wright, David J. P. Ferguson, Richard J. Wall, Sarah Whipple, David S. Guttery, Edward W. Tate, Bill Wickstead, Anthony A. Holder, Rita Tewari
Publikováno v:
Biology Open, Vol 2, Iss 11, Pp 1160-1170 (2013)
Summary The phylum Apicomplexa comprises over 5000 intracellular protozoan parasites, including Plasmodium and Toxoplasma, that are clinically important pathogens affecting humans and livestock. Malaria parasites belonging to the genus Plasmodium pos
Externí odkaz:
https://doaj.org/article/c2a6927f08964f51b6261b8ba121c980
Autor:
David S. Guttery, David J. P. Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M. Sandrini, Declan Brady, Conrad A. Nieduszynski, Chris J. Janse, Anthony A. Holder, Andrew B. Tobin, Rita Tewari
Publikováno v:
PLoS Pathogens, Vol 8, Iss 3 (2012)
Externí odkaz:
https://doaj.org/article/96c334274b244aff8bfc9ba5647621ae