Zobrazeno 1 - 10
of 266
pro vyhledávání: '"David J. Orlicky"'
Autor:
Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Mehdi A. Fini, Dean R. Tolan, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Hereditary fructose intolerance (HFI) is a painful and potentially lethal genetic disease caused by a mutation in aldolase B resulting in accumulation of fructose-1-phosphate (F1P). No cure exists for HFI and treatment is limited to avoid ex
Externí odkaz:
https://doaj.org/article/f9bcfa94f5f84ce2b5d0aa16b91d48ff
Autor:
Peter R. Baker, Amy S. Li, Benjamin R. Griffin, Hyo-Wook Gil, David J. Orlicky, Benjamin M. Fox, Bryan Park, Genevieve C. Sparagna, Jared Goff, Christopher Altmann, Hanan Elajaili, Kayo Okamura, Zhibin He, Daniel Stephenson, Angelo D’Alessandro, Julie A. Reisz, Eva S. Nozik, Carmen C. Sucharov, Sarah Faubel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Acute kidney injury (AKI) is a systemic disease that affects energy metabolism in various remote organs in murine models of ischemic AKI. However, AKI-mediated effects in the liver have not been comprehensively assessed. After inducing ische
Externí odkaz:
https://doaj.org/article/e75afd0af2434c049b30e596eeaa926d
Autor:
Liqiong Jiang, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, Daniel Parera, David J. Orlicky, Stephan Fischer, Michael Wegmann, Charles A. Dinarello, Suzhao Li
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MA
Externí odkaz:
https://doaj.org/article/043b9fc676264481860d024fe524374a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Prolonged parenteral nutrition (PN) can lead to PN associated cholestasis (PNAC). Intestinally derived lipopolysaccharides and infused PN phytosterols lead to activation of NFκB, a key factor in PNAC. Our objective was to determine if inhib
Externí odkaz:
https://doaj.org/article/bcbfa0e51eea4a5a91206133ecae5ba0
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/34ab8561f9914a09b8f9f35c4a46009d
Autor:
Ana Andres-Hernando, Christina Cicerchi, Gabriela E. Garcia, David J. Orlicky, Peter Stenvinkel, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106355- (2023)
Summary: Sarcopenia is a common and devastating condition in patients with chronic kidney disease (CKD). Here, we provide evidence that the kidney-muscle crosstalk in sarcopenia is mediated by reduced insulin sensitivity and the activation of the mus
Externí odkaz:
https://doaj.org/article/3b5fbfcffd0a46dd8920f4a9ce4e36c4
Autor:
Keith Z. Hazleton, Casey G. Martin, David J. Orlicky, Kathleen L. Arnolds, Nichole M. Nusbacher, Nancy Moreno-Huizar, Michael Armstrong, Nichole Reisdorph, Catherine A. Lozupone
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea, and emerging evidence has linked dietary components with CDI pathogenesis, suggesting that dietary modulation may be an effective strategy for preve
Externí odkaz:
https://doaj.org/article/a8b3f45e8c0b4fb7a7454bc638d31339
Autor:
Jeremy P. Koelmel, Wan Y. Tan, Yang Li, John A. Bowden, Atiye Ahmadireskety, Andrew C. Patt, David J. Orlicky, Ewy Mathé, Nicholas M. Kroeger, David C. Thompson, Jason A. Cochran, Jaya Prakash Golla, Aikaterini Kandyliari, Ying Chen, Georgia Charkoftaki, Joy D. Guingab‐Cagmat, Hiroshi Tsugawa, Anmol Arora, Kirill Veselkov, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Richard A. Yost, Timothy J. Garrett, Vasilis Vasiliou
Publikováno v:
Hepatology Communications, Vol 6, Iss 3, Pp 513-525 (2022)
Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies. Early detection permits in
Externí odkaz:
https://doaj.org/article/d5f7be9683684d59b0c25b597814b71a
Autor:
Colin T. Shearn, Aimee L. Anderson, Michael W. Devereaux, Karim C. El Kasmi, David J. Orlicky, Ronald J. Sokol
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Background We have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile
Externí odkaz:
https://doaj.org/article/3a6863291f8e40f58bc76c50a9fed31c
Autor:
Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol
Publikováno v:
Hepatology Communications, Vol 7, Iss 1, Pp e0020-e0020 (2023)
Background and Aims:. Cholestatic liver diseases, including primary sclerosing cholangitis, are characterized by periportal inflammation with progression to hepatic fibrosis and ultimately cirrhosis. We recently reported that the thioredoxin antioxid
Externí odkaz:
https://doaj.org/article/65bdde1608a44f779026293984db4f20