Zobrazeno 1 - 10
of 175
pro vyhledávání: '"David J. Odde"'
Autor:
Marcus D. Kelly, Matthew R. Pawlak, Kevin H. Zhan, Ghaidan A. Shamsan, Wendy R. Gordon, David J. Odde
Publikováno v:
APL Bioengineering, Vol 8, Iss 3, Pp 036102-036102-11 (2024)
Cell migration is the major driver of invasion and metastasis during cancer progression. For cells to migrate, they utilize the actin–myosin cytoskeleton and adhesion molecules, such as integrins and CD44, to generate traction forces in their envir
Externí odkaz:
https://doaj.org/article/1e07d54b25c34fafa4f2d643b0677027
Autor:
Matthew R. Pawlak, Adam T. Smiley, Maria Paz Ramirez, Marcus D. Kelly, Ghaidan A. Shamsan, Sarah M. Anderson, Branden A. Smeester, David A. Largaespada, David J. Odde, Wendy R. Gordon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Mechanical forces drive critical cellular processes that are reflected in mechanical phenotypes, or mechanotypes, of cells and their microenvironment. We present here “Rupture And Deliver” Tension Gauge Tethers (RAD-TGTs) in which flow c
Externí odkaz:
https://doaj.org/article/1fd6216c1397488692642b2a66cb4e0c
Autor:
Matthew A. Schaller, Yamini Sharma, Zadia Dupee, Duy Nguyen, Juan Urueña, Ryan Smolchek, Julia C. Loeb, Tiago N. Machuca, John A. Lednicky, David J. Odde, Robert F. Campbell, W. Gregory Sawyer, Borna Mehrad
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Cell lines are the mainstay in understanding the biology of COVID-19 infection but do not recapitulate many of the complexities of human infection. The use of human lung tissue is one solution for the study of such novel respiratory pathogens. We hyp
Externí odkaz:
https://doaj.org/article/507f58c1652342ce96c22df1224c403b
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101782- (2020)
Summary: Plus-end tracking proteins (+TIPs) associate with the growing end of microtubules and mediate important cellular functions. The majority of +TIPs are directed to the plus-end through a family of end-binding proteins (EBs), which preferential
Externí odkaz:
https://doaj.org/article/b978b96f865c4bef8f3df7519e3db59c
Autor:
Benjamin L. Bangasser, Ghaidan A. Shamsan, Clarence E. Chan, Kwaku N. Opoku, Erkan Tüzel, Benjamin W. Schlichtmann, Jesse A. Kasim, Benjamin J. Fuller, Brannon R. McCullough, Steven S. Rosenfeld, David J. Odde
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches,
Externí odkaz:
https://doaj.org/article/7f8be4a890ad4dfa87e307c6843951c7
Autor:
Rebecca L. Klank, Stacy A. Decker Grunke, Benjamin L. Bangasser, Colleen L. Forster, Matthew A. Price, Thomas J. Odde, Karen S. SantaCruz, Steven S. Rosenfeld, Peter Canoll, Eva A. Turley, James B. McCarthy, John R. Ohlfest, David J. Odde
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 668- (2017)
Externí odkaz:
https://doaj.org/article/e069b6395018405d9e00032b9247c54c
Autor:
Carolyn T, Bramante, Jared D, Huling, Christopher J, Tignanelli, John B, Buse, David M, Liebovitz, Jacinda M, Nicklas, Kenneth, Cohen, Michael A, Puskarich, Hrishikesh K, Belani, Jennifer L, Proper, Lianne K, Siegel, Nichole R, Klatt, David J, Odde, Darlette G, Luke, Blake, Anderson, Amy B, Karger, Nicholas E, Ingraham, Katrina M, Hartman, Via, Rao, Aubrey A, Hagen, Barkha, Patel, Sarah L, Fenno, Nandini, Avula, Neha V, Reddy, Spencer M, Erickson, Sarah, Lindberg, Regina, Fricton, Samuel, Lee, Adnin, Zaman, Hanna G, Saveraid, Walker J, Tordsen, Matthew F, Pullen, Michelle, Biros, Nancy E, Sherwood, Jennifer L, Thompson, David R, Boulware, Thomas A, Murray, Lena, Zinkl
Publikováno v:
New England Journal of Medicine. 387:599-610
Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.In this phase 3, double-blind, randomized, plac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ea7f5ed17796fea3024a4ded59fea4
https://doi.org/10.1056/nejmoa2201662
https://doi.org/10.1056/nejmoa2201662
Autor:
Aleksi Isomursu, Keun-Young Park, Jay Hou, Bo Cheng, Mathilde Mathieu, Ghaidan A. Shamsan, Benjamin Fuller, Jesse Kasim, M. Mohsen Mahmoodi, Tian Jian Lu, Guy M. Genin, Feng Xu, Min Lin, Mark D. Distefano, Johanna Ivaska, David J. Odde
Publikováno v:
Nature Materials. 21:1081-1090
How cells sense tissue stiffness to guide cell migration is a fundamental question in development, fibrosis and cancer. Although durotaxis-cell migration towards increasing substrate stiffness-is well established, it remains unknown whether individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe41b02974a27979a00d3bd651c2a5
https://doi.org/10.1038/s41563-022-01294-2
https://doi.org/10.1038/s41563-022-01294-2
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebcfc7720d1848ea19440c3e7a8f431f
https://doi.org/10.1158/0008-5472.c.6511413.v1
https://doi.org/10.1158/0008-5472.c.6511413.v1
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Figure S4. Shows ARHGAP36 expression in mouse and human neural tissue. Figure S5. Shows characterization of ARHGAP36 and Megf10 in C17.2 cells Figures S6-S7 show mechanistic analysis of FOXR2 in C17.2 and HSC1L cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88fb8090e9d0f93c8d64bec0f20df6
https://doi.org/10.1158/0008-5472.22423053
https://doi.org/10.1158/0008-5472.22423053