Výsledky vyhledávání - "David J. Odde"

Akademický článek

Mutual antagonism between CD44 and integrins in glioblastoma cell traction and migration

Autor: Marcus D. Kelly, Matthew R. Pawlak, Kevin H. Zhan, Ghaidan A. Shamsan, Wendy R. Gordon, David J. Odde

Publikováno v: APL Bioengineering, Vol 8, Iss 3, Pp 036102-036102-11 (2024)

Cell migration is the major driver of invasion and metastasis during cancer progression. For cells to migrate, they utilize the actin–myosin cytoskeleton and adhesion molecules, such as integrins and CD44, to generate traction forces in their envir

Externí odkaz: https://doaj.org/article/1e07d54b25c34fafa4f2d643b0677027

Zobrazit plný text záznamu

Akademický článek

RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes

Autor: Matthew R. Pawlak, Adam T. Smiley, Maria Paz Ramirez, Marcus D. Kelly, Ghaidan A. Shamsan, Sarah M. Anderson, Branden A. Smeester, David A. Largaespada, David J. Odde, Wendy R. Gordon

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract Mechanical forces drive critical cellular processes that are reflected in mechanical phenotypes, or mechanotypes, of cells and their microenvironment. We present here “Rupture And Deliver” Tension Gauge Tethers (RAD-TGTs) in which flow c

Externí odkaz: https://doaj.org/article/1fd6216c1397488692642b2a66cb4e0c

Zobrazit plný text záznamu

Akademický článek

Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses

Autor: Matthew A. Schaller, Yamini Sharma, Zadia Dupee, Duy Nguyen, Juan Urueña, Ryan Smolchek, Julia C. Loeb, Tiago N. Machuca, John A. Lednicky, David J. Odde, Robert F. Campbell, W. Gregory Sawyer, Borna Mehrad

Publikováno v: JCI Insight, Vol 6, Iss 18 (2021)

Cell lines are the mainstay in understanding the biology of COVID-19 infection but do not recapitulate many of the complexities of human infection. The use of human lung tissue is one solution for the study of such novel respiratory pathogens. We hyp

Externí odkaz: https://doaj.org/article/507f58c1652342ce96c22df1224c403b

Zobrazit plný text záznamu

Akademický článek

Tau Avoids the GTP Cap at Growing Microtubule Plus-Ends

Autor: Brian T. Castle, Kristen M. McKibben, Elizabeth Rhoades, David J. Odde

Publikováno v: iScience, Vol 23, Iss 12, Pp 101782- (2020)

Summary: Plus-end tracking proteins (+TIPs) associate with the growing end of microtubules and mediate important cellular functions. The majority of +TIPs are directed to the plus-end through a family of end-binding proteins (EBs), which preferential

Externí odkaz: https://doaj.org/article/b978b96f865c4bef8f3df7519e3db59c

Zobrazit plný text záznamu

Akademický článek

Shifting the optimal stiffness for cell migration

Autor: Benjamin L. Bangasser, Ghaidan A. Shamsan, Clarence E. Chan, Kwaku N. Opoku, Erkan Tüzel, Benjamin W. Schlichtmann, Jesse A. Kasim, Benjamin J. Fuller, Brannon R. McCullough, Steven S. Rosenfeld, David J. Odde

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches,

Externí odkaz: https://doaj.org/article/7f8be4a890ad4dfa87e307c6843951c7

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání