Zobrazeno 1 - 10
of 257
pro vyhledávání: '"David J. Nikolic‐Paterson"'
Autor:
David A. Vesey, Abishek Iyer, Evan Owen, Danielle Kamato, David W. Johnson, Glenda C. Gobe, David P. Fairlie, David J. Nikolic-Paterson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Key features of chronic kidney disease (CKD) include tubulointerstitial inflammation and fibrosis. Protease activated receptor-2 (PAR2), a G-protein coupled receptor (GPCR) expressed by the kidney proximal tubular cells, induces potent proinflammator
Externí odkaz:
https://doaj.org/article/acd3f424f03c4ce7a40cc0c7435e9fc3
Autor:
Natasha de Zoysa, Kotaro Haruhara, David J. Nikolic-Paterson, Peter G. Kerr, Jonathan Ling, Sarah E. Gazzard, Victor G. Puelles, John F. Bertram, Luise A. Cullen-McEwen
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatment is vari
Externí odkaz:
https://doaj.org/article/f1b0d3151ef243659d08ba006db972f9
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Autor:
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinom
Externí odkaz:
https://doaj.org/article/ba3ca05e7ec94b9aa2d7bbddfdfd4bef
Autor:
Fan Yang, Elyce Ozols, Frank Y. Ma, Khai Gene Leong, Greg H. Tesch, Xiaoyun Jiang, David J. Nikolic-Paterson
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/50392d401272425c9c2203ae36d2167b
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/ac9b1e2d1fd843299fe49c2718e7d104
Autor:
Fan Yang, Elyce Ozols, Frank Y. Ma, Khai Gene Leong, Greg H. Tesch, Xiaoyun Jiang, David J. Nikolic-Paterson
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Aristolochic acid (AA) is a toxin that induces DNA damage in tubular epithelial cells of the kidney and is the cause of Balkan Nephropathy and Chinese Herb Nephropathy. In cultured tubular epithelial cells, AA induces a pro-fibrotic response via the
Externí odkaz:
https://doaj.org/article/7e134452bf7a4335884514e7c2558e8d
Publikováno v:
Toxins, Vol 13, Iss 10, p 700 (2021)
The plant-derived toxin, aristolochic acid (AA), is the cause of Chinese Herb Nephropathy and Balkan Nephropathy. Ingestion of high dose AA induces acute kidney injury, while chronic low dose ingestion leads to progressive kidney disease. Ingested AA
Externí odkaz:
https://doaj.org/article/57e397cea0ba4b439d701b660ef3103c
Publikováno v:
Physiological Reports, Vol 7, Iss 18, Pp n/a-n/a (2019)
Abstract Clinical studies indicate that sex differences exist in susceptibility for developing diabetic kidney disease (DKD), supporting the need to examine both sexes in animal studies of DKD. Streptozotocin (STZ) is commonly used in male mice to in
Externí odkaz:
https://doaj.org/article/1e2cfc728f574ff499f44f500354a83e
Autor:
Mengjie Jiang, Jinjin Fan, Xinli Qu, Songhui Li, Susan K. Nilsson, Yu Bo Yang Sun, Yaping Chen, Di Yu, Dan Liu, Bi-Cheng Liu, Mingliang Tang, Wei Chen, Yi Ren, David J. Nikolic-Paterson, Xiaoyun Jiang, Jinhua Li, Xueqing Yu
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Acute kidney injury leading to chronic kidney disease through tubulointerstitial fibrosis is a major challenge in nephropathy. Several signaling pathways promote interstitial fibrosis; however, effective suppression of fibrosis may require blockade o
Externí odkaz:
https://doaj.org/article/04c29d8ec06c4c399c59b74ee124ebb2
Autor:
Hui Y. Lan, David J. Nikolic-Paterson
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/1707a2504bb54d6caaf8e41f366be320