Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David J. Montefusco"'
Autor:
Andrea K. Anderson, Johana M. Lambert, David J. Montefusco, Bao Ngan Tran, Patrick Roddy, William L. Holland, L. Ashley Cowart
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 10, Pp 1328-1340 (2020)
Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate
Externí odkaz:
https://doaj.org/article/cbb13923fd534ddfa828e7356b19f332
Autor:
Patrick Roddy, L. Ashley Cowart, David J. Montefusco, Johana M. Lambert, William L. Holland, Andrea K. Anderson, Bao Ngan Tran
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 10, Pp 1328-1340 (2020)
J Lipid Res
J Lipid Res
Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate
Publikováno v:
Biochemical and Biophysical Research Communications. 504:608-616
Non-alcoholic fatty liver disease (NAFLD) is a major clinical concern and its treatment consumes abundant resources. While accumulation of lipids in hepatocytes initiates the disease, this in itself is not necessarily harmful; rather, initiation of i
Autor:
Sara Omenetti, Lauren Ashley Cowart, L. Frenguelli, Ramon Bataller, Massimo Pinzani, Josepmaria Argemi, Ana Levi, Francesco De Chiara, Mark Kester, Sriram S. Shanmugavelandy, Fausto Andreola, Todd E. Fox, Lisa Longato, F. Zanieri, Juan Caballería, David J. Montefusco, Krista Rombouts, Giuseppe Mazza, Veronica Massey, Tu Vinh Luong, Constantino Fondevila
Publikováno v:
Cells, Vol 9, Iss 1237, p 1237 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Cells
Volume 9
Issue 5
Dipòsit Digital de la UB
Universidad de Barcelona
Cells
Volume 9
Issue 5
In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism has also been proposed. H
Autor:
L Ashley Cowart, Matthew Shotwell, Mitchell L Worley, Adam J Richards, David J Montefusco, Yusuf A Hannun, Xinghua Lu
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Sphingolipids including sphingosine‐1‐phosphate and ceramide participate in numerous cell programs through signaling mechanisms. This class of lipids has important functions in stress responses; however, determining which sphingolipid mediates sp
Externí odkaz:
https://doaj.org/article/4e7fa9016f66471189c943d876f5ae43
Autor:
Arun J. Sanyal, L. Ashley Cowart, David J. Montefusco, Sarah Spiegel, Timothy D. Rohrbach, Pierre Bedossa, Amon Asgharpour, Melissa A. Maczis
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 7, Pp 1311-1322 (2019)
J Lipid Res
J Lipid Res
Nonalcoholic fatty liver disease (NAFLD), a leading cause of liver dysfunction, is a metabolic disease that begins with steatosis. Sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate (S1P), have recently received attention for
Publikováno v:
Chemistry and Physics of Lipids. 177:26-40
Sphingolipids are recognized as signaling mediators in a growing number of pathways, and represent potential targets to address many diseases. The study of sphingolipid signaling in yeast has created a number of breakthroughs in the field, and has th
Autor:
Benjamin Newcomb, Jason L. Gandy, L. Ashley Cowart, Nabil Matmati, Sarah E. Brice, David J. Montefusco, Yusuf A. Hannun
Publikováno v:
Journal of Biological Chemistry. 287:9280-9289
Targets of bioactive sphingolipids in Saccharomyces cerevisiae were previously identified using microarray experiments focused on sphingolipid-dependent responses to heat stress. One of these heat-induced genes is the serine deamidase/dehydratase Cha
Publikováno v:
Journal of Biological Chemistry. 284:8241-8246
Saccharomyces cerevisiae cells lacking ISC1 (inositol phosphosphingolipase C) exhibit sensitivity to genotoxic agents such as methyl methanesulfonate and hydroxyurea (HU). Cell cycle analysis by flow cytometry revealed a G(2)/M block in isc1Delta cel
Publikováno v:
Biochemistry. 42:13379-13385
Transmembrane receptors in the signaling pathways of bacterial chemotaxis systems influence cell motility by forming noncovalent complexes with the cytoplasmic signaling proteins to regulate their activity. The requirements for receptor-mediated acti