Zobrazeno 1 - 10
of 371
pro vyhledávání: '"David J. Mikulis"'
Cerebral perfusion metrics calculated directly from a hypoxia-induced step change in deoxyhemoglobin
Autor:
James Duffin, Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Resting cerebral perfusion metrics can be calculated from the MRI ΔR2* signal during the first passage of an intravascular bolus of a Gadolinium-based contrast agent (GBCA), or more recently, a transient hypoxia-induced change in the concen
Externí odkaz:
https://doaj.org/article/12568e23cccb48909bbdc57866bedd4b
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, James Duffin
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Use of contrast in determining hemodynamic measures requires the deconvolution of an arterial input function (AIF) selected over a voxel in the middle cerebral artery to calculate voxel wise perfusion metrics. Transfer function analysis
Externí odkaz:
https://doaj.org/article/7301816458004c009d79cb51b09b77e4
Autor:
Yashesh Dasari, James Duffin, Ece Su Sayin, Harrison T. Levine, Julien Poublanc, Andrea E. Para, David J. Mikulis, Joseph A. Fisher, Olivia Sobczyk, Mir Behrad Khamesee
Publikováno v:
Healthcare, Vol 11, Iss 16, p 2231 (2023)
Cerebrovascular Reactivity (CVR) is a provocative test used with Blood oxygenation level-dependent (BOLD) Magnetic Resonance Imaging (MRI) studies, where a vasoactive stimulus is applied and the corresponding changes in the cerebral blood flow (CBF)
Externí odkaz:
https://doaj.org/article/3bf494d5c4d945f4914ba3d42a516cf0
Autor:
Saurabh Sihag, Sébastien Naze, Foad Taghdiri, Melisa Gumus, Charles Tator, Robin Green, Brenda Colella, Kaj Blennow, Henrik Zetterberg, Luis Garcia Dominguez, Richard Wennberg, David J. Mikulis, Maria C. Tartaglia, James R. Kozloski
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-14 (2022)
Sihag et al. analyse brain imaging data, circulating neurofilament light chain levels and personality scores in a cohort of former athletes with a history of concussions. The authors use graph signal processing to identify brain structural and connec
Externí odkaz:
https://doaj.org/article/76b22a0035f340ca81f0b11054dc2e46
Autor:
Alex A. Bhogal, Ece Su Sayin, Julien Poublanc, James Duffin, Joseph A. Fisher, Olivia Sobcyzk, David J. Mikulis
Publikováno v:
NeuroImage, Vol 261, Iss , Pp 119523- (2022)
Cerebral blood arrival and tissue transit times are sensitive measures of the efficiency of tissue perfusion and can provide clinically meaningful information on collateral blood flow status. We exploit the arterial blood oxygen level dependent (BOLD
Externí odkaz:
https://doaj.org/article/a356a5d8dec340f594f0363498ac4fbf
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, Kevin H. M. Kuo, James Duffin
Publikováno v:
Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)
Abstract In patients with sickle cell disease (SCD), the delivery of oxygen to the brain is compromised by anemia, abnormal rheology, and steno‐occlusive vascular disease. Successful compensation depends on an increase in oxygen supply such as that
Externí odkaz:
https://doaj.org/article/86e3a224da09422f91535b9ccb790851
Autor:
Reema Shafi, Adrian P. Crawley, Maria Carmela Tartaglia, Charles H. Tator, Robin E. Green, David J. Mikulis, Angela Colantonio
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Concussions are associated with a range of cognitive, neuropsychological and behavioral sequelae that, at times, persist beyond typical recovery times and are referred to as postconcussion syndrome (PCS). There is growing support that concus
Externí odkaz:
https://doaj.org/article/7fa6b3f28b5e4e0c873f7a592116a371
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, Kevin H. M. Kuo, James Duffin
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In patients with sickle cell disease (SCD) the delivery of oxygen to the brain is compromised by anemia, abnormal rheology, and steno-occlusive vascular disease. Meeting demands for oxygen delivery requires compensatory features of brain perfusion. T
Externí odkaz:
https://doaj.org/article/461cb4c9f69f425dacff27abf7daba42
Autor:
Olivia Sobczyk, Jorn Fierstra, Lakshmikumar Venkatraghavan, Julien Poublanc, James Duffin, Joseph A. Fisher, David J. Mikulis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
An increase in arterial PCO2 is the most common stressor used to increase cerebral blood flow for assessing cerebral vascular reactivity (CVR). That CO2 is readily obtained, inexpensive, easy to administer, and safe to inhale belies the difficulties
Externí odkaz:
https://doaj.org/article/c4e850a578194c928da2be1cee80e9df
Autor:
Julien Poublanc, Reema Shafi, Olivia Sobczyk, Kevin Sam, Daniel M. Mandell, Lakshmikumar Venkatraghavan, James Duffin, Joseph A. Fisher, David J. Mikulis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cerebrovascular reactivity (CVR) is defined as the change in cerebral blood flow induced by a change in a vasoactive stimulus. CVR using BOLD MRI in combination with changes in end-tidal CO2 is a very useful method for assessing vascular performance.
Externí odkaz:
https://doaj.org/article/269635b053af44ee9aacd979b4139742