Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David J. McGarry"'
Autor:
David J. McGarry, Giovanni Castino, Sergio Lilla, Alexandre Carnet, Loughlin Kelly, Katarina Micovic, Sara Zanivan, Michael F. Olson
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111442- (2022)
Summary: The MICAL1 monooxygenase is an important regulator of filamentous actin (F-actin) structures. Although MICAL1 has been shown to be regulated via protein-protein interactions at the autoinhibitory carboxyl terminus, a link between actin-regul
Externí odkaz:
https://doaj.org/article/0dc737e63c4e447d911c2e48fde6180a
Autor:
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-21 (2022)
Abstract Despite the clinical benefit of androgen‐deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration‐resistant prostate cancer (CRPC). In this study, we identified thioeste
Externí odkaz:
https://doaj.org/article/0b32d6de175042e18b789240104f3924
Autor:
Gabriela Kalna, Susan M. Mason, Matthew Neilson, David J. McGarry, June Munro, Michael F. Olson, Margaret Mullin, Daniela Moralli, Huabing Yin, Ann Hedley, Aleksandra Ptak, Catherine M. Green, Karen Blyth, Dominika A. Rudzka, Ya-Hua Chim, Giulia Spennati
Publikováno v:
Journal of Cell Science
Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression by facilitating cell movement through physically constraining environments. To identify pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c366adc85877399ab32c8a67b0c4b80
https://doi.org/10.32920/21985079.v1
https://doi.org/10.32920/21985079.v1
Autor:
David J. McGarry, Giovanni Castino, Sergio Lilla, Alexandre Carnet, Loughlin Kelly, Katarina Micovic, Sara Zanivan, Michael F. Olson
Publikováno v:
Cell reports. 41(1)
The MICAL1 monooxygenase is an important regulator of filamentous actin (F-actin) structures. Although MICAL1 has been shown to be regulated via protein-protein interactions at the autoinhibitory carboxyl terminus, a link between actin-regulatory RHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84649178af63d3e7607051a94e0f3ee
https://pubmed.ncbi.nlm.nih.gov/36198272
https://pubmed.ncbi.nlm.nih.gov/36198272
SummaryThe MICAL1 monooxygenase has emerged as an important regulator of filamentous actin (F-actin) structures that contribute to numerous processes including nervous system development, cell morphology, motility, viability and cytokinesis [1–4].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::485b531f5f4536c0ec5dec5e45311b05
https://doi.org/10.1101/2021.09.15.460490
https://doi.org/10.1101/2021.09.15.460490
Autor:
Giulia Spennati, Michael F. Olson, Albert Folch, David J. McGarry, Huabing Yin, Dominika A. Rudzka, Lisa F. Horowitz, Garett Armstrong
Publikováno v:
Exp Cell Res
Metastasis is the leading cause of mortality in cancer patients. To migrate to distant sites, cancer cells would need to adapt their behaviour in response to different tissue environments. Thus, it is essential to study this process in models that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988abc1973b89784fb546a2e0429c1b
https://eprints.gla.ac.uk/236184/3/236184.pdf
https://eprints.gla.ac.uk/236184/3/236184.pdf
Autor:
Duncan Graham, Peter Repiscak, Elke Markert, Gillian M. Mackay, Rodriguez Blanco G, Arnaud Blomme, Zanivan, Rahima Patel, Huabing Yin, Susan L. Mason, Edward Avezov, Colin Nixon, Grace McGregor, Pierre Close, David J. McGarry, Kevin G. Blyth, Lauren E. Jamieson, Ernest Mui, Marc Thiry, Linda K. Rushworth, Ladan Fazli, Jurre J. Kamphorst, Karen Faulds, Mason Lm, Joanne Edwards, Peter C, Sergio Lilla, Daniel J. Murphy, Chara Ntala, Catriona A. Ford, Mark Salji, David Sumpton, Hing Y. Leung, Martin E. Gleave, Sonia Kung
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892c0885f644b9c87d9815d35acd2a6f
https://doi.org/10.1101/2021.04.04.438378
https://doi.org/10.1101/2021.04.04.438378
Autor:
Michael F. Olson, David J. McGarry, Karen Blyth, Giovanni Castino, Lynn McGarry, Robin M. Shaw, Garett Armstrong, William C. Clark, Susan M. Mason
Publikováno v:
Cancer letters. 519
The Molecule Interacting with CasL 1 (MICAL1) monooxygenase has emerged as an important regulator of cytoskeleton organization via actin oxidation. Although filamentous actin (F-actin) increases MICAL1 monooxygenase activity, hydrogen peroxide (H2O2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e636d50327e8294ac3a91912cbe1b2
https://pubmed.ncbi.nlm.nih.gov/34314753
https://pubmed.ncbi.nlm.nih.gov/34314753
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 355:137-144
Acetaminophen (APAP) is the most commonly used over-the-counter analgesic. However, hepatotoxicity induced by APAP is a major clinical issue, and the factors that define sensitivity to APAP remain unclear. We have previously demonstrated that mice nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af2f438a1d76a318e1c44ffd00a53ba
https://doi.org/10.1124/jpet.115.227389
https://doi.org/10.1124/jpet.115.227389
Autor:
Douglas L. Lamont, C. Roland Wolf, Colin J. Henderson, Probir Chakravarty, Wenzhang Chen, David J. McGarry
Publikováno v:
Biochemical Journal. 469:25-32
Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and pathways regulated by S-glutathionylation in whole organisms and current approaches lack th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522f1cd286dd5af71101de10b861a99e
https://doi.org/10.1042/bj20141256
https://doi.org/10.1042/bj20141256