Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David J. McDermitt"'
Publikováno v:
eLife, Vol 13 (2024)
The location of different actin-based structures is largely regulated by Rho GTPases through specific effectors. We use the apical aspect of epithelial cells as a model system to investigate how RhoA is locally regulated to contribute to two distinct
Externí odkaz:
https://doaj.org/article/b9c8ed00c55b47a5ad78dec76feb769a
Autor:
Andrew T. Lombardo, Cameron A. R. Mitchell, Riasat Zaman, David J. McDermitt, Anthony Bretscher
The assembly of a three-dimensional actin cytoskeleton is largely mediated by local Rho GTPases. Restriction of microvilli to the epithelial apical surface requires local regulation of actin structure. On epithelial cells, the presence of microvilli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c9b68bde41c9497f1218c4c674a88c
https://doi.org/10.1101/2022.09.12.507663
https://doi.org/10.1101/2022.09.12.507663
Autor:
Song Eun Lee, Aiko Sada, Meng Zhang, David J. McDermitt, Shu Yang Lu, Kenneth J. Kemphues, Tudorita Tumbar
Publikováno v:
Cell Reports, Vol 6, Iss 3, Pp 499-513 (2014)
Quiescent hair follicle (HF) bulge stem cells (SCs) differentiate to early progenitor (EP) hair germ (HG) cells, which divide to produce transit-amplifying matrix cells. EPs can revert to SCs upon injury, but whether this dedifferentiation occurs in
Externí odkaz:
https://doaj.org/article/ee2d713c328d4ca182555c7a4e5643d4
Autor:
Anthony Bretscher, Matthew R Miller, Riasat Zaman, Andrew J Lombardo, David J. McDermitt, Cécile Sauvanet
Publikováno v:
Molecular Biology of the Cell. 33
Here we report on the related TBC/RabGAPs EPI64A and EPI64B and show that they function to organize the apical aspect of epithelial cells. EPI64A binds the scaffolding protein EBP50/NHERF1, which itself binds active ezrin in epithelial cell microvill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c11d399df671662e2b932d3956fb13
https://doi.org/10.1091/mbc.e21-05-0268
https://doi.org/10.1091/mbc.e21-05-0268
Autor:
Andrew Lombardo, Cécile Sauvanet, David J. McDermitt, Riasat Zaman, Raghuvir Viswanatha, Valerie Awad, Anthony Bretscher, Locke Ezra-Ros Bonomo
Publikováno v:
The Journal of Cell Biology
Zaman and Lombardo et al. characterize cells lacking all ERM proteins or their activating kinases. This reveals that active ERMs are local negative regulators of RhoA necessary to mediate the architecture of the apical domain.
Activated ezrin-ra
Activated ezrin-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350db153c14765221def2f7dbb00b21
http://europepmc.org/articles/PMC8185690
http://europepmc.org/articles/PMC8185690
Publikováno v:
The EMBO Journal. 31:4124-4139
Cancers and tissue stem cells (SCs) share similar molecular pathways for their self-renewal and differentiation. The race is on to identify unique pathways to specifically target the cancer, while sparing normal SCs. Here, we uncover the transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0b0db39920af73939371c186bad175
https://doi.org/10.1038/emboj.2012.270
https://doi.org/10.1038/emboj.2012.270
Autor:
Shu Y. Lu, Rachel M. Peters, Caroline M. Piskun, Song Eun Lee, Ralf Paus, Tudorita Tumbar, Karen M. Osorio, Charlene S. L. Hoi, David J. McDermitt
Publikováno v:
Molecular and Cellular Biology. 30:2518-2536
Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in morphogenesis impairs normal adult hair homeostasis (cycle) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb990f14f35112a168aac062bc52fd8a
https://doi.org/10.1128/mcb.01308-09
https://doi.org/10.1128/mcb.01308-09
Publikováno v:
Cell stem cell. 5(3)
SummaryIn homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell committed to differentiate. This model is based lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5ba9fa80cbff553c14a66050239366
https://pubmed.ncbi.nlm.nih.gov/19664980
https://pubmed.ncbi.nlm.nih.gov/19664980
Autor:
David J. McDermitt, Karen M. Osorio, Hyun Nyun Woo, Song Eun Lee, Ying V. Zhang, Tudorita Tumbar, Sanjeev K. Waghmare
Publikováno v:
Development (Cambridge, England). 135(6)
Aml1/Runx1 controls developmental aspects of several tissues, is a master regulator of blood stem cells, and plays a role in leukemia. However, it is unclear whether it functions in tissue stem cells other than blood. Here, we have investigated the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0b9a3ec5ed8b732418c9316be563b3
https://pubmed.ncbi.nlm.nih.gov/18256199
https://pubmed.ncbi.nlm.nih.gov/18256199
Autor:
Rajat Bansal, Ying V. Zhang, Tudorita Tumbar, Jayhun Lee, Sanjeev K. Waghmare, David J. McDermitt
Publikováno v:
The EMBO journal. 27(9)
Regulation of stem cell (SC) proliferation is central to tissue homoeostasis, injury repair, and cancer development. Accumulation of replication errors in SCs is limited by either infrequent division and/or by chromosome sorting to retain preferentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc429414eb2518d679906939248fcb5b
https://pubmed.ncbi.nlm.nih.gov/18401343
https://pubmed.ncbi.nlm.nih.gov/18401343