Zobrazeno 1 - 10
of 202
pro vyhledávání: '"David J. McAdoo"'
Publikováno v:
European Journal of Mass Spectrometry. 26:187-194
The question of whether [CH2OH]+ should be described as the hydroxymethyl cation, +CH2OH, or protonated formaldehyde, CH2=OH+, is reconsidered in the light of experimental information and new computational evidence. Previous arguments that the charge
Autor:
David J. McAdoo, Young Seob Gwak, Eric D. Crown, Huai Yu Tan, Zaiming Ye, Kathia M. Johnson, Claire E. Hulsebosch, Guo Ying Xu
Publikováno v:
Pain. 153:710-721
Chronic central neuropathic pain after central nervous system injuries remains refractory to therapeutic interventions. A novel approach would be to target key intracellular signaling proteins that are known to contribute to continued activation by p
Autor:
Zaiming Sam Ye, Guo-Ying Xu, Claire E. Hulsebosch, Song Liu, Clement Echetebu, David J. McAdoo, Kathia M. Johnson
Publikováno v:
Brain Research. 1231:63-74
Elevation of extracellular glutamate contributes to cell death and functional impairments generated by spinal cord injury (SCI), in part through the activation of the neurotoxic cytokine interleukin-1beta (IL-1beta). This study examines the participa
Autor:
Ghassan H. Abu Said, Saraswathy Manickavasagam, Yu Lin, Regino Perez-Polo, Yochai Birnbaum, David J. McAdoo, Yumei Ye, Michael G. Hughes
Publikováno v:
Cardiovascular Drugs and Therapy
We asked whether caffeinated coffee (CC) blunts the infarct size (IS)-limiting effects of atorvastatin (ATV).Adenosine receptor activation is essential for mediating the IS-limiting effects of statins. Caffeine is a nonspecific adenosine receptor blo
Publikováno v:
International Journal of Mass Spectrometry. 266:8-14
We use theory to determine the relative rates of 4-, 5- and 6-membered ring H-transfers in closed shell cations, a comparison not possible experimentally due to interference from competing processes. H-transfers of increasing ring size were character
Autor:
Yewen Wu, Ning Ping Yang, Charles Y. Lui, William R. Roeske, Yu Lin, David J. McAdoo, Hui Qun Wang, Michael G. Hughes, Paul J. Boor, Yumei Ye, Barry F. Uretsky, Ming He Huang, Scott D. Lick, Yochai Birnbaum
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H376-H384
Stimulation of cardiac β2-adrenergic receptor (β2-AR) or δ-opioid receptor (DOR) exerts a similar degree of cardioprotection against myocardial ischemia in experimental models. We hypothesized that δ-opioid-initiated cardioprotection is mediated
Autor:
Yochai Birnbaum, Regino Perez-Polo, Ming He Huang, Yu Lin, David J. McAdoo, Michael G. Hughes, Saraswathy Manickavasagam, Yumei Ye, Barry F. Uretsky
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H813-H818
Atorvastatin (ATV) limits infarct size (IS) by activating Akt and ecto-5-nucleotidase, which generates adenosine. Activated Akt and adenosine activate endothelial nitric oxide synthase (eNOS). When given orally, high doses (10 mg/kg) are needed to ac
Autor:
David J. McAdoo, Charles E. Hudson
Publikováno v:
Journal of the American Society for Mass Spectrometry. 18:270-278
H-transfers by 4-, 5-, and 6-membered ring transition states to the pi-bonded methylene of CH3CH2CH2NH+=CH2 (1) are characterized by theory and compared with the corresponding transfers in cation radicals. Four-membered ring H-transfers converting 1
Autor:
Clement Echetebu, David J. McAdoo, Linghui Nie, Michael G. Hughes, Claire E. Hulsebosch, Kathia M. Johnson, Lisa D. Cain, Guo Ying Xu
Publikováno v:
Journal of Neuroscience Research. 85:1558-1567
A neuroprotective factor is shown to be present in mammalian serum. This factor is identified by Western blotting to be serum albumin. The serum factor and albumin both protected cultured spinal cord neurons against the toxicity of glutamate. The ina
Publikováno v:
Neuroscience Letters. 410:183-186
Increased release of substance P (SP) from the dorsal horn following noxious stimuli, such as spinal administration of capsaicin, has been demonstrated in previous studies. However, changes in the release of SP in response to intradermal injection of