Zobrazeno 1 - 10
of 113
pro vyhledávání: '"David J. Mayer"'
Spinal Cord Neuroplasticity following Repeated Opioid Exposure and Its Relation to Pathological Pain
Autor:
David J. Mayer, Jianren Mao
Publikováno v:
Annals of the New York Academy of Sciences. 933:175-184
Convincing evidence has accumulated that indicates neuroplastic changes within the spinal cord in response to repeated exposure to opioids. Such neuroplastic changes occur at both cellular and intracellular levels. It has been generally acknowledged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2606ed9cf25f025a8fb8fa057ceccb
https://doi.org/10.1111/j.1749-6632.2001.tb05823.x
https://doi.org/10.1111/j.1749-6632.2001.tb05823.x
Autor:
David J. Mayer
Publikováno v:
Annual Review of Medicine. 51:49-63
This chapter reviews the experimental literature on the effects of acupuncture treatment. The review covers the 14 medical conditions for which the National Institutes of Health Acupuncture Consensus Development Panel (NIHCDP) concluded that acupunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762d5a1a4e80c00079a619198b2789c4
https://doi.org/10.1146/annurev.med.51.1.49
https://doi.org/10.1146/annurev.med.51.1.49
Publikováno v:
Journal of Pain and Symptom Management. 19:7-11
A model proposing that N-methyl-D-aspartate (NMDA) receptor and opioid receptor mechanisms overlap and interact within the same dorsal horn nociceptive neurons makes several predictions. First, hyperalgesia should be associated with opioid tolerance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f68439e468bb15d0fa6db034fcfcb39
https://doi.org/10.1016/s0885-3924(99)00121-9
https://doi.org/10.1016/s0885-3924(99)00121-9
Autor:
David J. Mayer, Jianren Mao
Publikováno v:
Pain Forum. 8:14-18
This Commentary evaluates several observations and hypotheses made by Fundytus and Coderre: (1) Initial treatment with high doses of μ-opioid agonists decrease phosphatidlylinositol (PI) hydrolysis, while (2) chronic treatment increases PI hydrolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb1d4809d90bcffc06043c5af369b91
https://doi.org/10.1016/s1082-3174(99)70014-0
https://doi.org/10.1016/s1082-3174(99)70014-0
Publikováno v:
Pain. 72:355-366
Transsynaptic alteration of spinal cord dorsal horn neurons characterized by hyperchromatosis of cytoplasm and nucleoplasm (so-called 'dark' neurons) occurs in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cc1661747faba9246c1d2c28fa7cee
https://doi.org/10.1016/s0304-3959(97)00063-8
https://doi.org/10.1016/s0304-3959(97)00063-8
Publikováno v:
Pain. 68:119-127
The effects of combined single oral treatments with non-steroidal anti-inflammatory drugs (NSAIDs) and the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dextromethorphan (DM) on arthritic pain were examined in a rat model of adjuvan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4088dff3ba6ca124e7757f383dd287df
https://doi.org/10.1016/s0304-3959(96)03183-1
https://doi.org/10.1016/s0304-3959(96)03183-1
Publikováno v:
Pain. 67:79-88
N-Methyl-D-aspartate (NMDA) receptor antagonists have been repeatedly shown to attenuate the development of opiate tolerance and dependence in rodents. In the present experiments, continuous subcutaneous infusion of either MK-801 (0.01 mg/kg/h but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d4745010ddf00993bc91bb7021e33f
https://doi.org/10.1016/0304-3959(96)81972-5
https://doi.org/10.1016/0304-3959(96)81972-5
Publikováno v:
Neuroscience Letters. 198:75-78
Eight days after chronic constrictive sciatic nerve injury (CCI), protein kinase C gamma (PKC gamma) immunoreactivity reliably increased in the spinal cord dorsal horn of CCI rats with demonstrable thermal hyperalgesia as compared to sham-operated co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb95165c9bffa315d579d8907cbe970b
https://doi.org/10.1016/0304-3940(95)11975-3
https://doi.org/10.1016/0304-3940(95)11975-3
Publikováno v:
Pain. 61:365-374
The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92f416fb5dfee35bffa7f01f57946b0
https://doi.org/10.1016/0304-3959(95)00023-l
https://doi.org/10.1016/0304-3959(95)00023-l
Publikováno v:
Brain Research. 677:257-267
Our previous studies have indicated a critical role of protein kinase C (PKC) in intracellular mechanisms of tolerance to morphine analgesia. In the present experiments, we examined (1) the cellular distribution of a PKC isoform (PKC gamma) in the sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdf965d4b5528bff3fe1305c5a9de7c
https://doi.org/10.1016/0006-8993(95)00161-i
https://doi.org/10.1016/0006-8993(95)00161-i