Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis

Autor: David J. Matye, Xuan Qin, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Feng Li, Tiangang Li

Publikováno v: Liver Research, Vol 6, Iss 4, Pp 276-283 (2022)

Background and aims: Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis (NASH) treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver fibrosis in many patients. R

Externí odkaz: https://doaj.org/article/beea8ecf722143c8bf8cb6f59073c383

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

Autor: Yifeng Wang, Sumedha Gunewardena, Feng Li, David J. Matye, Cheng Chen, Xiaojuan Chao, Taeyoon Jung, Yuxia Zhang, Maciej Czerwiński, Hong-Min Ni, Wen-Xing Ding, Tiangang Li

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

Externí odkaz: https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce

Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice

Autor: Cheng Chen, David J. Matye, Yifeng Wang, Tiangang Li

Publikováno v: Liver Research, Vol 5, Iss 4, Pp 232-238 (2021)

Background The liver plays a key role in regulating whole body cholesterol homeostasis. Hepatic cholesterol accumulation causes liver injury in fatty liver disease and hypercholesterolemia increases the risk of cardiovascular disease. MicroRNAs (miRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e6c7704f8e489e1440572efb444701
http://www.sciencedirect.com/science/article/pii/S2542568420300416

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

Autor: Wen-Xing Ding, Lijie Gu, Wenyi Luo, Rachel R. Sharp, Tiangang Li, Kenneth Jones, Cheng Chen, Huaiwen Wang, David J. Matye, Jacob E. Friedman

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1001-1019 (2021)

Background & Aims Pharmacologic agents targeting bile acid signaling show promise for treating nonalcoholic steatohepatitis (NASH). However, clinical findings suggest that new treatment strategies with enhanced therapeutic efficacy and minimized unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a85e199ea05eb85c515efcdf28c3d70
https://pubmed.ncbi.nlm.nih.gov/33965587

Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice

Autor: David J. Matye, Tiangang Li, Yifeng Wang, Jibiao Li

Publikováno v: FEBS Letters. 591:1018-1028

Sortilin 1 (Sort1) is a trafficking receptor that has been implicated in the regulation of plasma cholesterol in humans and mice. Here, we use metabolomics and hyperinsulinemic-euglycemic clamp approaches to obtain further understanding of the in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9f139cce3323b71d1c41b93d001036
https://doi.org/10.1002/1873-3468.12610