Zobrazeno 1 - 10
of 121
pro vyhledávání: '"David J. Mann"'
Autor:
Bo Qin, Gregory B. Craven, Pengjiao Hou, Julian Chesti, Xinran Lu, Emma S. Child, Rhodri M.L. Morgan, Wenchao Niu, Lina Zhao, Alan Armstrong, David J. Mann, Sheng Cui
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 10, Pp 3924-3933 (2022)
RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional proteins. Many of these proteases exhibit a similar fold and contain an essential catalytic cysteine, offering the opportunity to inh
Externí odkaz:
https://doaj.org/article/39dbc59016b1467c8583478d4ae5e8af
Autor:
Silvia Martini, Khalil Davis, Rupert Faraway, Lisa Elze, Nicola Lockwood, Andrew Jones, Xiao Xie, Neil Q. McDonald, David J. Mann, Alan Armstrong, Jernej Ule, Peter J. Parker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of ch
Externí odkaz:
https://doaj.org/article/d5e625f8ebda47a580e2c0dff47b3aba
Autor:
Peter A. Summers, Benjamin W. Lewis, Jorge Gonzalez-Garcia, Rosa M. Porreca, Aaron H. M. Lim, Paolo Cadinu, Nerea Martin-Pintado, David J. Mann, Joshua B. Edel, Jean Baptiste Vannier, Marina K. Kuimova, Ramon Vilar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Direct observation of G-quadruplexes (G4s) in live cells is challenging. Here the authors report a method to identify G4s within the nuclei of live and fixed cells using a fluorescent probe combined with fluorescence lifetime imaging microscopy.
Externí odkaz:
https://doaj.org/article/37fc31773c234ea49cb172f66805dd72
Autor:
Charlotte L. Bevan, Marjorie M. Walker, Jonathan Waxman, Robin Wait, Sue M. Powell, Simon C. Gamble, Bradley Spencer-Dene, Craig N. Robson, Stuart R. McCracken, Luke Gaughan, David J. Mann, D. Alwyn Dart, Rachel L. Culley, Greg N. Brooke
Supplementary Figures 1-6, Table 1 from FUS/TLS Is a Novel Mediator of Androgen-Dependent Cell-Cycle Progression and Prostate Cancer Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fe951f1375f2eebf0e91b4d13e45f1
https://doi.org/10.1158/0008-5472.22388270.v1
https://doi.org/10.1158/0008-5472.22388270.v1
Autor:
Khalil Davis, David J. Mann, Ulrike S. Eggert, John D. Scott, Steven Lynham, Victoria Crossland, Xiaoping Yang, Tanya N. Soliman, Peter J. Parker, Alan Armstrong, Neil Q. McDonald, Lisa Watson, Joanna R. Kelly, Nicola Lockwood
Publikováno v:
Biochemical Journal
A requirement for PKCε in exiting from the Aurora B dependent abscission checkpoint is associated with events at the midbody, however, the recruitment, retention and action of PKCε in this compartment are poorly understood. Here, the prerequisite f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d85219ff82fd92ec0f42d125307988a
http://europepmc.org/articles/PMC8238520
http://europepmc.org/articles/PMC8238520
Autor:
Ramon Vilar, Nerea Martin-Pintado, Rosa Maria Porreca, Joshua B. Edel, Jorge González-García, Marina K. Kuimova, Aaron H. M. Lim, David J. Mann, Jean-Baptiste Vannier, Benjamin W. Lewis, Paolo Cadinu, Peter A. Summers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Guanine rich regions of oligonucleotides fold into quadruple-stranded structures called G-quadruplexes (G4s). Increasing evidence suggests that these G4 structures form in vivo and play a crucial role in cellular processes. However, their direct obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd75d6088e29b9f7859762ac3105ea6
https://doaj.org/article/37fc31773c234ea49cb172f66805dd72
https://doaj.org/article/37fc31773c234ea49cb172f66805dd72
Autor:
Teresa Kösel, Zoë H. Jukes, Tsz Lam M. Wong, Dominic P. Affron, Chun‐Ting Liu, Alan Armstrong, Gregory B. Craven, Rhodri M. L. Morgan, David J. Mann
Publikováno v:
Chembiochem
Chemical probes that covalently modify cysteine residues in a protein‐specific manner are valuable tools for biological investigations. Covalent fragments are increasingly implemented as probe starting points, but the complex relationship between f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc64dad8bd162bde83f607eccec6cbe
https://doi.org/10.1002/cbic.202000457
https://doi.org/10.1002/cbic.202000457
Autor:
Andrew W. Jones, Nicola Lockwood, Jernej Ule, Rupert Faraway, Peter J. Parker, Alan Armstrong, Lisa Elze, Silvia Martini, Neil Q. McDonald, Xiao Xie, Khalil Davis, David J. Mann
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The PKCε-regulated genome protective pathway provides transformed cells a failsafe to successfully complete mitosis. Despite the necessary role for Aurora B in this programme, it is unclear whether its requirement is sufficient or if other PKCε cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8aa6a78f8d71fc005add38786136ec
https://doi.org/10.1038/s41467-021-27189-5
https://doi.org/10.1038/s41467-021-27189-5
Publikováno v:
Chemistry – A European Journal. 25:9691-9700
Guanine-rich sequences of DNA are known to readily fold into tetra-stranded helical structures known as G-quadruplexes (G4). Due to their biological relevance, G4s are potential anticancer drug targets and therefore there is significant interest in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a17249e4357af60790014f1193387f5
https://doi.org/10.1002/chem.201901569
https://doi.org/10.1002/chem.201901569
Publikováno v:
Bio Protoc
Small molecules that react to form covalent bonds with proteins are widely used as biological tools and therapeutic agents. Screening cysteine-reactive fragments against a protein target is an efficient way to identify chemical starting points for co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da78619911fe7a8e0bbf456b15c28591
https://europepmc.org/articles/PMC7842680/
https://europepmc.org/articles/PMC7842680/