Zobrazeno 1 - 10
of 167
pro vyhledávání: '"David J. Maloney"'
Autor:
Dorjbal Dorjsuren, Richard T. Eastman, Kathryn J. Wicht, Daniel Jansen, Daniel C. Talley, Benjamin A. Sigmon, Alexey V. Zakharov, Norma Roncal, Andrew T. Girvin, Yevgeniya Antonova-Koch, Paul M. Will, Pranav Shah, Hongmao Sun, Carleen Klumpp-Thomas, Sachel Mok, Tomas Yeo, Stephan Meister, Juan Jose Marugan, Leila S. Ross, Xin Xu, David J. Maloney, Ajit Jadhav, Bryan T. Mott, Richard J. Sciotti, Elizabeth A. Winzeler, Norman C. Waters, Robert F. Campbell, Wenwei Huang, Anton Simeonov, David A. Fidock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We report a phenotyp
Externí odkaz:
https://doaj.org/article/3166e3dd3b5945e88b4f3c4eb22c8065
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12985-12998 (2018)
Externí odkaz:
https://doaj.org/article/8724422ba81f42db9ffcf8ba59f6f176
Autor:
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to dete
Externí odkaz:
https://doaj.org/article/b3f7874afa484caba2d1087fcf914a16
Autor:
Anil K. Sood, Jason Roszik, Jeffrey W. Strovel, Makoto Yoshioka, David J. Maloney, Shyh-Ming Yang, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Keith Baggerly, Ying Wang, Prahlad T. Ram, Cristina Ivan, Margaret I. Engelhardt, Mamur A. Chowdhury, Christopher LaFargue, Shaolin Ma, Karem A. Court, Sherry Y. Wu, Alejandro Villar-Prados
Systematic approaches for accurate repurposing of targeted therapies are needed. We developed and aimed to biologically validate our therapy predicting tool (TPT) for the repurposing of targeted therapies for specific tumor types by testing the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be2de628b875d9d86eeb590868649f07
https://doi.org/10.1158/1535-7163.c.6538684.v1
https://doi.org/10.1158/1535-7163.c.6538684.v1
Autor:
Yves Pommier, Anton Simeonov, William L. Jorgensen, Ajit Jadhav, David J. Maloney, Rui Gao, Junko Murai, Ganesha Rai, Andrew S. Rosenthal, Andrew G. Stephen, Alena Naumova, Adel Chergui, Bryan T. Mott, Wendy A. Lea, Thomas S. Dexheimer, Shar-yin N. Huang, Christophe Marchand
PDF - 89K, Supplementary Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d5add5479ee0c6b7bc31f570cc144d
https://doi.org/10.1158/1535-7163.22499952
https://doi.org/10.1158/1535-7163.22499952
Autor:
Yves Pommier, Anton Simeonov, William L. Jorgensen, Ajit Jadhav, David J. Maloney, Rui Gao, Junko Murai, Ganesha Rai, Andrew S. Rosenthal, Andrew G. Stephen, Alena Naumova, Adel Chergui, Bryan T. Mott, Wendy A. Lea, Thomas S. Dexheimer, Shar-yin N. Huang, Christophe Marchand
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I–, alkylation-, and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da67e855c35dcbf7a605e7960b2fa0d
https://doi.org/10.1158/1535-7163.c.6536313
https://doi.org/10.1158/1535-7163.c.6536313
Autor:
Anil K. Sood, Jason Roszik, Jeffrey W. Strovel, Makoto Yoshioka, David J. Maloney, Shyh-Ming Yang, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Keith Baggerly, Ying Wang, Prahlad T. Ram, Cristina Ivan, Margaret I. Engelhardt, Mamur A. Chowdhury, Christopher LaFargue, Shaolin Ma, Karem A. Court, Sherry Y. Wu, Alejandro Villar-Prados
Raw RPPA data for OVCAR 5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b36c75d0be4e676b54549d12b8da3c8
https://doi.org/10.1158/1535-7163.22507423
https://doi.org/10.1158/1535-7163.22507423
Autor:
Yves Pommier, Anton Simeonov, William L. Jorgensen, Ajit Jadhav, David J. Maloney, Rui Gao, Junko Murai, Ganesha Rai, Andrew S. Rosenthal, Andrew G. Stephen, Alena Naumova, Adel Chergui, Bryan T. Mott, Wendy A. Lea, Thomas S. Dexheimer, Shar-yin N. Huang, Christophe Marchand
PDF - 65K, IC50 value table.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09296a0685de8fe5a21239ef514e99f4
https://doi.org/10.1158/1535-7163.22499949.v1
https://doi.org/10.1158/1535-7163.22499949.v1
Autor:
Yves Pommier, Anton Simeonov, William L. Jorgensen, Ajit Jadhav, David J. Maloney, Rui Gao, Junko Murai, Ganesha Rai, Andrew S. Rosenthal, Andrew G. Stephen, Alena Naumova, Adel Chergui, Bryan T. Mott, Wendy A. Lea, Thomas S. Dexheimer, Shar-yin N. Huang, Christophe Marchand
PDF - 188K, Suface Plasmon Resonance (SPR) profiles binding for JLT048 and NCGC00183674 to recombinant TDP1 bound to the surface.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350aa0725c4f0a1b165690b9a6494fae
https://doi.org/10.1158/1535-7163.22499955
https://doi.org/10.1158/1535-7163.22499955
Autor:
Yves Pommier, Anton Simeonov, William L. Jorgensen, Ajit Jadhav, David J. Maloney, Rui Gao, Junko Murai, Ganesha Rai, Andrew S. Rosenthal, Andrew G. Stephen, Alena Naumova, Adel Chergui, Bryan T. Mott, Wendy A. Lea, Thomas S. Dexheimer, Shar-yin N. Huang, Christophe Marchand
PDF - 119K, Schematic representation of the AlphaScreen 3'-phospho-tyrosine DNA substrate used in the TDP1 qHTS assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd203ca03e1e8060cb73dc089ec355
https://doi.org/10.1158/1535-7163.22499958.v1
https://doi.org/10.1158/1535-7163.22499958.v1