Zobrazeno 1 - 10
of 59
pro vyhledávání: '"David J. M. Lewis"'
Autor:
Zarni Win, January Weiner 3rd, Allan Listanco, Neva Patel, Rohini Sharma, Aldona Greenwood, Jeroen Maertzdorf, Hans-Joachim Mollenkopf, Kat Pizzoferro, Thomas Cole, Caroline L. Bodinham, Stefan H. E. Kaufmann, Philippe Denoel, Giuseppe Del Giudice, David J. M. Lewis
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Systems vaccinology has been applied to detect signatures of human vaccine induced immunity but its ability, together with high definition in vivo clinical imaging is not established to predict vaccine reactogenicity. Within two European Commission f
Externí odkaz:
https://doaj.org/article/58d5f258b0bd468683395ce6caa2d3ec
Autor:
Mariëlle C. Haks, Barbara Bottazzi, Valentina Cecchinato, Corinne De Gregorio, Giuseppe Del Giudice, Stefan H. E. Kaufmann, Antonio Lanzavecchia, David J. M. Lewis, Jeroen Maertzdorf, Alberto Mantovani, Federica Sallusto, Marina Sironi, Mariagrazia Uguccioni, Tom H. M. Ottenhoff
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Vaccinology aims to understand what factors drive vaccine-induced immunity and protection. For many vaccines, however, the mechanisms underlying immunity and protection remain incompletely characterized at best, and except for neutralizing antibodies
Externí odkaz:
https://doaj.org/article/65d3b04e4b2b4dbdaaf274f535facbcc
Autor:
David J. M. Lewis, Mark P. Lythgoe
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Advances in “omics” technology (transcriptomics, proteomics, metabolomics, genomics/epigenomics, etc.) allied with statistical and bioinformatics tools are providing insights into basic mechanisms of vaccine and adjuvant efficacy or inflammation/
Externí odkaz:
https://doaj.org/article/456ebab227e24f2cb9e686c32de6cc5d
Autor:
Robert A. van den Berg, Geert Leroux-Roels, David J. M. Lewis, Stefan H. E. Kaufmann, Hans-Joachim Mollenkopf, Ingileif Jonsdottir, Aldona Greenwood, Catherine Linley, Giuseppe Del Giudice, Kat Pizzoferro, Caroline L. Bodinham, Kent E. Kester, Jeroen Maertzdorf, January Weiner, Alberto Mantovani, Barbara Bottazzi, Philippe Denoel
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpatient clinical studies (NCT01765413/NCT017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb82a2ccd27deedea20670fbdf7b86c
http://link.springer.com/article/10.1038/s41598-019-56994-8
http://link.springer.com/article/10.1038/s41598-019-56994-8
Autor:
Philip R. Johnson, J. Fraser Wright, Huub C. Gelderblom, Bruce C. Schnepp, Celia C. LaBranche, Hana Hassanin, Jonathan Hare, Jill Gilmour, Eddy Sayeed, Frances Priddy, Daryl Bendel, David C. Montefiori, Jim Ackland, David J. M. Lewis, Claire Streatfield, Len Dally, Josephine H. Cox
Publikováno v:
The Lancet. HIV
Summary Background A preventive vaccine for HIV is a crucial public health need; adeno-associated virus (AAV)-mediated antibody gene delivery could be an alternative to immunisation to induce sustained expression of neutralising antibodies to prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cb8bf3ac5969691b6293a1ac150e5b
http://europepmc.org/articles/PMC6443625
http://europepmc.org/articles/PMC6443625
Autor:
Laurent Fraisse, Marie-Helene Grillet, Yasemin Ataman-Önal, Tobias Manigold, Emmanuel Feroldi, Sébastien Laurent, David J. M. Lewis, Patrick Syntin, Benjamin Chousterman, Nicholas Jackson, Michel Doubovetzky, Nicolas Burdin, Ernesto Luna, Daniel Kramer, Nathalie Garçon
Publikováno v:
Vaccine. 38(51)
Vaccines prevent infectious diseases, but vaccination is not without risk and adverse events are reported although they are more commonly reported for biologicals than for vaccines. Vaccines and biologicals must undergo vigorous assessment before and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b867202d080cbd8e56148a89e6a21c6
https://pubmed.ncbi.nlm.nih.gov/33187767
https://pubmed.ncbi.nlm.nih.gov/33187767
Autor:
David J. M. Lewis, Antonio Lanzavecchia, Philipp Carl Georg Paparoditis, Federica Sallusto, Ramgopal R. Mettu, Marco Benevento, Antonino Cassotta, Alessia Donati, Roger Geiger, Samuel J. Landry, Mathilde Foglierini
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 217 (10)
Journal of Experimental Medicine, 217 (10)
The importance of CD4+ T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265984ca7b591f83195ea3d72d835e78
https://pubmed.ncbi.nlm.nih.gov/32644114
https://pubmed.ncbi.nlm.nih.gov/32644114
Autor:
Odile Launay, Antonella Silvia Sciré, Jochen Auerbach, David J. M. Lewis, Anaïs Maugard, Alessandra Anemona, Oretta Finco, Simona Rondini, Stefano Zancan, Audino Podda, Pierre Loulergue, Allan Saul, Jo Leahy, Laura B. Martin, Daniel Cohen, Zhiming Huo, Rachid Marhaba, Christiane Gerke, Elisa Marchetti
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 164-172 (2017)
EBioMedicine
EBioMedicine
Summary Background Approximately 164,000 deaths yearly are due to shigellosis, primarily in developing countries. Thus, a safe and affordable Shigella vaccine is an important public health priority. The GSK Vaccines Institute for Global Health (GVGH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd52977a4e35bafe88fd1fff45957fbd
http://www.sciencedirect.com/science/article/pii/S2352396417302864
http://www.sciencedirect.com/science/article/pii/S2352396417302864
Autor:
Kathleen Pizzoferro, Roger Le Grand, Jamila Elhmouzi-Younes, Antonio Cosma, Anne-Sophie Beignon, Jean-Louis Palgen, Caroline L. Bodinham, Nicolas Tchitchek, Simon Delandre, David J. M. Lewis, Inana Namet
Publikováno v:
Cytometry Part A. 91:969-982
Comparative immune-profiling of innate responses in humans and non-human primates is important to understand the pathogenesis of infectious and chronic inflammatory diseases as well as for the preclinical development of vaccines and immune therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998ee20111b37a6931db16d3a938f93e
https://doi.org/10.1002/cyto.a.23107
https://doi.org/10.1002/cyto.a.23107
Autor:
Claire Streatfield, Philip R. Johnson, Bruce C. Schnepp, Celia C. LaBranche, Eddy Sayeed, Huub C. Gelderblom, Jim Ackland, Jonathan Hare, Daryl Bendel, Hana Hassanin, David J. M. Lewis, Fraser Wright, David C. Montefiori, Josephine H. Cox, Jill Gilmour, Frances Priddy, Len Dally
Publikováno v:
SSRN Electronic Journal.
Background: A preventive vaccine for HIV is a critical public health need. Adeno-associated virus (AAV) mediated antibody gene delivery could be an alternative to immunization to induce sustained expression of neutralizing antibodies to prevent HIV.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c5c640d394b7b07b894a6dc8e7f163
https://doi.org/10.2139/ssrn.3234859
https://doi.org/10.2139/ssrn.3234859