Zobrazeno 1 - 10
of 40
pro vyhledávání: '"David J. Lundy"'
Autor:
Dora Livkisa, Tsung-Lin Lee, Wei-Ting Yeh, Manuel S.V. Jaimes, Barbara Szomolay, Chia-Te Liao, David J. Lundy
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing phenotypes. This study uses a factorial experimental design to explore the interactions between circulating EV
Externí odkaz:
https://doaj.org/article/d048f9540d374f42a4df1dc7a132141b
Autor:
Andreas Czosseck, Max M. Chen, Chuan-Chih Hsu, Gleb Shamrin, Annette Meeson, Rachel Oldershaw, Helen Nguyen, Dora Livkisa, David J. Lundy
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Cell therapy can protect cardiomyocytes from hypoxia, primarily via paracrine secretions, including extracellular vesicles (EVs). Since EVs fulfil specific biological functions based on their cellular origin, we hypothesised that
Externí odkaz:
https://doaj.org/article/67621a7377144eda8b90365e7b677080
Publikováno v:
MethodsX, Vol 13, Iss , Pp 102822- (2024)
This work describes protocols for preparing specific forms of human platelet lysates from pooled platelet concentrates (PCs) and the isolation of platelet-derived extracellular vesicles (p-EVs). Clinical-grade PCs can be sourced from blood establishm
Externí odkaz:
https://doaj.org/article/ec2292d65fcb4b94b13af603034bc874
Autor:
Hung-Chih Chen, Yen-Wen Liu, Kuan-Cheng Chang, Yen-Wen Wu, Yi-Ming Chen, Yu-Kai Chao, Min-Yi You, David J. Lundy, Chen-Ju Lin, Marvin L. Hsieh, Yu-Che Cheng, Ray P. Prajnamitra, Po-Ju Lin, Shu-Chian Ruan, David Hsin-Kuang Chen, Edward S. C. Shih, Ke-Wei Chen, Shih-Sheng Chang, Cindy M. C. Chang, Riley Puntney, Amy Wu Moy, Yuan-Yuan Cheng, Hsin-Yuan Chien, Jia-Jung Lee, Deng-Chyang Wu, Ming-Jing Hwang, Jennifer Coonen, Timothy A. Hacker, C-L. Eric Yen, Federico E. Rey, Timothy J. Kamp, Patrick C. H. Hsieh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The gut microbiome and its metabolites are increasingly implicated in several cardiovascular diseases, but their role in human myocardial infarction (MI) injury responses have yet to be established. To address this, we examined stool samples
Externí odkaz:
https://doaj.org/article/6361bc3495944b3fb58bc006af3e56af
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-34 (2023)
Abstract Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential cellular product transfused by hospitals to control or prevent
Externí odkaz:
https://doaj.org/article/e9412d78ce9d46b98fc9b4653e85b548
Autor:
Manuel S. V. Jaimes, Chia‐Te Liao, Max M. Chen, Andreas Czosseck, Tsung‐Lin Lee, Yu‐Hsiang Chou, Yung‐Ming Chen, Shuei‐Liong Lin, James J. Lai, David J. Lundy
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 5, Pp n/a-n/a (2023)
Abstract Calorie restriction (CR) and fasting affect lifespan, disease susceptibility and response to acute injury across multiple animal models, including ischaemic injuries such as myocardial infarction or kidney hypoxia. The cargo and function of
Externí odkaz:
https://doaj.org/article/7423ec3d8ad94608bdc03b76dd6838f6
Autor:
Rachel A. Oldershaw, Gavin Richardson, Phillippa Carling, W. Andrew Owens, David J. Lundy, Annette Meeson
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3143 (2022)
There is significant interest in the role of stem cells in cardiac regeneration, and yet little is known about how cardiac disease progression affects native cardiac stem cells in the human heart. In this brief report, cardiac mesenchymal stem cell-l
Externí odkaz:
https://doaj.org/article/beeda38117114a2cb70fb9e64822e0b6
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 930 (2022)
Myocardial infarction is a major cause of morbidity and mortality worldwide. Due to poor inherent regeneration of the adult mammalian myocardium and challenges with effective drug delivery, there has been little progress in regenerative therapies. Na
Externí odkaz:
https://doaj.org/article/699b236dba30411391a62492437b6915
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1193 (2021)
Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still unco
Externí odkaz:
https://doaj.org/article/020b31e7e31e42efbc6501175b21dbd9
Autor:
Hung-Chih Chen, Yu-Feng Chin, David J. Lundy, Chung-Tiang Liang, Ya-Hui Chi, Paolin Kuo, Patrick C. H. Hsieh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn −/− mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the cli
Externí odkaz:
https://doaj.org/article/574d967a664547919ea2d5da8ee9fe37