Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David J. Leap"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Hematopoietic stem cell (HSC) gene therapy using retroviral vectors has immense potential, but vector-mediated genotoxicity limits use in the clinic. Lentiviral vectors are less genotoxic than gammaretroviral vectors and have become the vector of cho
Externí odkaz:
https://doaj.org/article/2201aae48230457abff7caa32a1eeb7f
Publikováno v:
Science Advances
The nervous system regulates C. elegans defense against pathogen infection by controlling the dynamics of cuticle structure.
Increasing evidence indicates that infection-triggered host defenses are regulated by the nervous system. However, the p
Increasing evidence indicates that infection-triggered host defenses are regulated by the nervous system. However, the p
Autor:
Diana L. Browning, Jonah D. Hocum, G Stamatoyannopoulos, Grant D. Trobridge, Hongjie Wang, David J. Leap, Elizabeth M Everson
Publikováno v:
Gene therapy
Retroviral vector mediated stem cell gene therapy is a promising approach for the treatment of hematopoietic disorders. However, genotoxic side effects from integrated vector proviruses are a significant concern for the use of retroviral vectors in t
Autor:
Jonah D. Hocum, David J. Leap, Diana L. Browning, Casey P. Collins, Dustin T. Rae, Grant D. Trobridge
Publikováno v:
Human gene therapy. 27(3)
Retroviral vector-mediated gene therapy is promising, but genotoxicity has limited its use in the clinic. Genotoxicity is highly dependent on the retroviral vector used, and foamy viral (FV) vectors appear relatively safe. However, internal promoters
Publikováno v:
Molecular Therapy. 24:S1
Hematopoietic stem cell (HSC) gene therapy has immense potential for numerous diseases including primary immunodeficiencies. However, in some SCID-X1 patients treated with gammaretroviral vectors, leukemia occurred as a result of vector mediated geno
Autor:
Ojan Assadian, Keith F. Cutting, David J. Leaper, Axel Kramer, Verena Dosch, Johannes Leitgeb, Rupert Schuster, Christina Forstner
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 10582-10590 (2013)
A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics. The antimicrobial efficacy
Externí odkaz:
https://doaj.org/article/ede2264d86394dd9be20823aa5a4f3ef