Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

Autor: David J. Kopsky, Ruben P. A. van Eijk, Janna K. Warendorf, Jan M. Keppel Hesselink, Nicolette C. Notermans, Alexander F. J. E. Vrancken

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-12 (2022)

Abstract Background Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side effects. Topical phen

Externí odkaz: https://doaj.org/article/db56635dbdde4c95a546042ab8944751

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Autor: David J. Kopsky, Jan M. Keppel Hesselink

Publikováno v: Pharmaceuticals, Vol 11, Iss 4, p 122 (2018)

Background: Phenytoin cream applied topically has been explored in neuropathic pain conditions. In several case series, phenytoin 5% and 10% cream could reduce pain in a clinically relevant way with a fast onset of action within 30 min, and with posi

Externí odkaz: https://doaj.org/article/e8bb0b956b6f423698eec1560961e509

Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy

Autor: Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J. Kopsky

Publikováno v: Journal of Ophthalmology, Vol 2015 (2015)

Retinopathy is a threat to the eyesight, and glaucoma and diabetes are the main causes for the damage of retinal cells. Recent insights pointed out a common pathogenetic pathway for both disorders, based on chronic inflammation. Palmitoylethanolamide

Externí odkaz: https://doaj.org/article/caee3ba225e740cf81ee721870c5c663

Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline

Autor: David J. Kopsky, Remko Liebregts, Jan M. Keppel Hesselink

Publikováno v: Case Reports in Medicine, Vol 2012 (2012)

Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events

Externí odkaz: https://doaj.org/article/8491f51dc9a846f98b307859ce5ca304

Study Design Characteristics and Endpoints for Enriched Enrollment Randomized Withdrawal Trials for Chronic Pain Patients: A Systematic Review

Autor: David J Kopsky, Karolina M Szadek, Patrick Schober, Alexander FJE Vrancken, Monique AH Steegers

Publikováno v: Kopsky, D J, Szadek, K M, Schober, P, Vrancken, A F JE & Steegers, M A H 2022, ' Study Design Characteristics and Endpoints for Enriched Enrollment Randomized Withdrawal Trials for Chronic Pain Patients : A Systematic Review ', Journal of Pain Research, vol. 15, pp. 479-496 . https://doi.org/10.2147/JPR.S334840

Enriched enrollment randomized withdrawal (EERW) pain trials are designed to include only responders with considerable pain relief without unacceptable side effects into the randomized phase. There are no recommendations for primary endpoints in such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ca27f5efd2782c4430eff13f6cc00
https://doi.org/10.2147/jpr.s334840