Zobrazeno 1 - 10
of 41
pro vyhledávání: '"David J. Judah"'
Autor:
Karl W. Broman, Andrew G. Smith, Bruce Clothier, Gemma R. Grant, Susan W. Robinson, David J. Judah, R.E. Edwards, Reginald Davies
Publikováno v:
Hepatology. 44:174-185
Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5633bd2264428d5a9a75f8877593e27
https://doi.org/10.1002/hep.21233
https://doi.org/10.1002/hep.21233
Autor:
David J. Judah, David Dinsdale, R.E. Edwards, Bruce Clothier, Andrew G. Smith, Peter Greaves, Reginald Davies, Arenda Schuurman, Colin R. Barker, Fiona M. Higginson, Timothy W. Gant, Tatyana Chernova
Publikováno v:
The American Journal of Pathology. 166:1041-1053
BALB/c Fech(m1Pas) mice have a mutated ferrochelatase gene resulting in protoporphyria that models the hepatic injury occurring sporadically in human erythropoietic protoporphyria. We used this mouse model to study the development of the injury and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cb219fb87c97f2b0537b9b8008bb57
https://doi.org/10.1016/s0002-9440(10)62325-5
https://doi.org/10.1016/s0002-9440(10)62325-5
Autor:
Jerry Styles, Doron Lipson, Andrew G. Smith, Joan Riley, Nicola J. Turton, Reginald Davies, David J. Judah, Timothy W. Gant
Publikováno v:
Oncogene. 20:1300-1306
The multidrug resistance (MDR) phenotype is a major cause of cancer treatment failure. Here the expressions of 4224 genes were analysed for association with intrinsic or acquired doxorubicin (DOX) resistance. A cluster of overexpressed genes related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbc9910423cf6ce28ab29e9b73a8559
https://doi.org/10.1038/sj.onc.1204235
https://doi.org/10.1038/sj.onc.1204235
Publikováno v:
Cancer Letters. 137:173-181
Ingestion of aflatoxin B1 is implicated in the high incidence of human liver cancers in several developing countries. An association has been detected between human exposure to aflatoxins, and mutations in the third base of codon 249 of the p53 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8389691b2a449818d523d8a38f9b8718
https://doi.org/10.1016/s0304-3835(98)00354-1
https://doi.org/10.1016/s0304-3835(98)00354-1
Autor:
David J. Judah, Gordon E. Neal, C R Wolf, P. D. Mcdonagh, John D. Hayes, L. Y. Lian, G. C. K. Roberts
Publikováno v:
Biochemical Journal. 339:95-101
We have used homology modelling, based on the crystal structure of the human glutathione S-transferase (GST) A1-1, to obtain the three-dimensional structures of rat GSTA3 and rat GSTA5 subunits bound to S-aflatoxinyl–glutathione. The resulting mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f736bf4557feaf2c776526ad853fef4b
https://doi.org/10.1042/bj3390095
https://doi.org/10.1042/bj3390095
Publikováno v:
Journal of Agricultural and Food Chemistry. 46:2707-2713
Differences in the expression and catalytic activity of hepatic biotransformation enzymes account for species differences in xenobiotic metabolism, including that of aflatoxin B1 (AFB1). The main objectives of this study were (1) to define the proced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba0c39709d41343e22ecd5eaf0824777
https://doi.org/10.1021/jf980062x
https://doi.org/10.1021/jf980062x
Publikováno v:
Carcinogenesis. 18:905-910
Activation of ras proto-oncogenes occurs frequently in vivo in chemically induced rodent tumours, including rat hepatomas induced by aflatoxin B 1 . This study examines the in vitro activation of a human ras gene by this mycotoxin. A plasmid containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffbbe09962242912fa3e4dd9428208f
https://doi.org/10.1093/carcin/18.5.905
https://doi.org/10.1093/carcin/18.5.905
Publikováno v:
Proceedings of the National Academy of Sciences. 90:10350-10354
Protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1) can be achieved through the induction of detoxification enzymes by chemoprotectors such as the phenolic antioxidant ethoxyquin. We have cloned and sequenced a cDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a150042182aabf4a8c9688d9d273a6
https://doi.org/10.1073/pnas.90.21.10350
https://doi.org/10.1073/pnas.90.21.10350
Autor:
Gordon C. K. Roberts, John D. Hayes, Ji-Chun Yang, David J. Judah, Gordon E. Neal, Peter B. Farmer, Lu-Yun Lian, John H. Lamb
Publikováno v:
Europe PubMed Central
In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic fractions prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724072b67148fde66f9366f24934bdbd
https://doi.org/10.1042/bj2920013
https://doi.org/10.1042/bj2920013
Autor:
Gordon E. Neal, G M Kirby, C R Wolf, David J. Judah, Colin J. Henderson, P Srivatanakul, Christopher P. Wild
Publikováno v:
Carcinogenesis. 14:2613-2620
Liver tissues were obtained from 20 liver cancer patients from Thailand, an area where the incidence of this tumour is high and where exposure to aflatoxin occurs. The expression of hepatic cytochrome P450s (P450) and glutathione S-transferase (GST)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bfce8c5423236c409a3498846f2aa5
https://doi.org/10.1093/carcin/14.12.2613
https://doi.org/10.1093/carcin/14.12.2613