Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David J. Jebaratnam"'
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
(1; R = Ph) [65899-49-2] C12H13NO2 (MW 203.09) InChI = 1S/C12H13NO2/c1-2-3-9-13-12(14)15-10-11-7-5-4-6-8-11/h2-9H,1,10H2,(H,13,14) InChIKey = LSQDRSXFUSBRBP-UHFFFAOYSA-N (2; R = Me) [61759-61-3] C7H11NO2 (MW 141.08) InChI = 1S/C7H11NO2/c1-3-5-6-8-7(9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4b6ca59a5893b0c1bf45b0a5929494b
https://doi.org/10.1002/047084289x.rb049.pub2
https://doi.org/10.1002/047084289x.rb049.pub2
Publikováno v:
The Journal of Organic Chemistry. 64:5644-5649
Enediyne anticancer antibiotics have attracted tremendous interest in the past decade. The inherent difficulty in synthesizing these structurally complex natural products with the strained enediyne moiety has motivated a search for simpler molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb47b52cc8366c42bbf0cf20a09e7be
https://doi.org/10.1021/jo990750v
https://doi.org/10.1021/jo990750v
Publikováno v:
Journal of the American Chemical Society. 121:6183-6192
The palladium-catalyzed enyne cycloisomerization is used as a key ring-forming process for the obtention of the cis-fused hydrindane carbon skeleton characteristic of the picrotoxanes sesquiterpenes. The enyne cycloisomerization product is suitably f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a721f90940bc5799aff5fe895673510f
https://doi.org/10.1021/ja9901821
https://doi.org/10.1021/ja9901821
Autor:
Dev P. Arya, David J. Jebaratnam
Publikováno v:
Tetrahedron Letters. 36:4369-4372
1,4-bisdiazonium compounds, which may be precursors of aryl 1,4-diradicals, have the potential to mimic the DNA cleaving activity of the enediyne antibiotics. To this end, the ability to generate and activate 1,4-bisdiazonium compounds in good yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52eb12048e0ccfb9c8d9def4f218033d
https://doi.org/10.1016/0040-4039(95)00815-t
https://doi.org/10.1016/0040-4039(95)00815-t
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1191-1196
It is demonstrated that aryl diamine 1 , designed after a d(A·T) specific minor groove binding agent, can serve as a precursor for the synthesis of two DNA cleaving (bisdiazonium 2 and bisazoester 5 ) and one crosslinking (bisazide 7 ) agents and, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a063ae415982575b9d0af62a71e4998d
https://doi.org/10.1016/0960-894x(95)00193-w
https://doi.org/10.1016/0960-894x(95)00193-w
Publikováno v:
Tetrahedron Letters. 36:3123-3126
It is demonstrated that azoester compounds are suitable for inducing DNA cleavage under physiological conditions. In particular, ethyl phenydiazenecarboxylate 1 and potassium phenyldiazenecarboxylate 2 have been shown to cleave ΦX174 supercoiled DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84d8f97bb2b97a7b46c47889cb52fc3b
https://doi.org/10.1016/0040-4039(95)00480-z
https://doi.org/10.1016/0040-4039(95)00480-z
Publikováno v:
Tetrahedron Letters. 36:1601-1604
In glycosylations utilizing SnCl 4 activation or S N 2 displacement of the α-chlorosugar, two closely related purines, namely 6-nitro-1,3-dideazapurine 1 and 6-nitro-1-deazapurine 2 , give different distributions of isomeric products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e9ab2a5ca027c0bfa82eb64de169be5
https://doi.org/10.1016/0040-4039(95)00098-w
https://doi.org/10.1016/0040-4039(95)00098-w
Autor:
David J. Jebaratnam, Theresa A. Devlin
Publikováno v:
Synthetic Communications. 25:711-718
The preparation of the titled compound has been conveniently achieved in five steps, and in 43% overall yield. The large scale monoreduction of 2,6-dinitroaniline, and the stannic chloride catalyzed glycosylation of 4 to obtain 6 as the only product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f1480ccf1c3bc7f6bdf39e64881d42
https://doi.org/10.1080/00397919508011408
https://doi.org/10.1080/00397919508011408
Autor:
David J. Jebaratnam, Johann Kordel, Jonathan J. Lee, Roberto Kolter, Peter Yorgey, Eugenio I. Vivas, Philip M. Warner
Publikováno v:
Proceedings of the National Academy of Sciences. 91:4519-4523
Drugs that inhibit the activity of DNA gyrase fall almost exclusively into two structural classes, the quinolones and the coumarins. A third class of DNA gyrase inhibitor is defined by the ribosomally synthesized peptide antibiotic microcin B17 (MccB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b7ed9695b6e3bef80208202a905b65
https://doi.org/10.1073/pnas.91.10.4519
https://doi.org/10.1073/pnas.91.10.4519
Publikováno v:
Tetrahedron Letters. 34:7823-7826
The bisdiazonium compound 1 has been shown to cleave DNA at concentrations as low as 0.1 μM. Evidence is presented to indicate that 1 is binding to the minor groove of DNA, and that binding may be responsible for its effectiveness as a DNA cleaving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5674a2cf987586afdf6a0c5678d7d369
https://doi.org/10.1016/s0040-4039(00)61485-5
https://doi.org/10.1016/s0040-4039(00)61485-5