Zobrazeno 1 - 10
of 37
pro vyhledávání: '"David J. J. de Gorter"'
Autor:
Eugenie Werbenko, David J. J. de Gorter, Simon Kleimann, Denise Beckmann, Vanessa Waltereit-Kracke, Julia Reinhardt, Fabienne Geers, Peter Paruzel, Uwe Hansen, Thomas Pap, Theresia E. B. Stradal, Berno Dankbar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bone resorption is highly dependent on the dynamic rearrangement of the osteoclast actin cytoskeleton to allow formation of actin rings and a functional ruffled border. Hem1 is a hematopoietic-specific subunit of the WAVE-complex which regul
Externí odkaz:
https://doaj.org/article/7158c6618faa4174a45185de02e0dde3
Autor:
Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in
Externí odkaz:
https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340
Autor:
Rizi Ai, Uwe Hansen, Johanna Intemann, Elsa Leitão, Toni Weinhage, Isabell Begemann, Joachim Kremerskothen, Anja Römer-Hillmann, Ho-Ryun Chung, Marianne Heitzmann, Thomas Pap, Hermann Pavenstädt, Hans P. Kiener, Na Li, Annika Krause, Wei Wang, Gilles Gasparoni, Berno Dankbar, Sylvia Müller, Corinna Wehmeyer, Denise Beckmann, Dirk Foell, Philip Rosenstiel, Bernhard Horsthemke, Thomas Kamradt, Adelheid Korb-Pap, Karl Nordström, Hans Schnittler, David J. J. de Gorter, Nico Lindemann, Jörn Walter, Gary S. Firestein, Xinyi Yang, Nina Gasparoni, Christopher Schröder, Jan Hillen, Milos Galic
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the ag
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114475 (2014)
Bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor (TGF)-β family, transduce their signal through multiple components downstream of their receptors. Even though the components involved in the BMP signaling pathway have
Externí odkaz:
https://doaj.org/article/5a1b6ff1a7bd4387bd51c7b621721061
Autor:
Songting Shi, Jie Cai, David J J de Gorter, Gonzalo Sanchez-Duffhues, Dwi U Kemaladewi, Willem M H Hoogaars, Annemieke Aartsma-Rus, Peter A C 't Hoen, Peter ten Dijke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69096 (2013)
Fibrodysplasia ossificans progressiva (FOP) is a rare heritable disease characterized by progressive heterotopic ossification of connective tissues, for which there is presently no definite treatment. A recurrent activating mutation (c.617G→A; R206
Externí odkaz:
https://doaj.org/article/8b10ff0983c3452c99d42c526bccbfd9
Autor:
Stephanie Stahnke, Frieda Kage, Michael Sixt, Aleks Guledani, Klemens Rottner, Theresia E.B. Stradal, Anika Steffen, Charly Kusch, Bernhard Nieswandt, Hermann Döring, Sebastian Dütting, Manfred Rohde, Michael Schnoor, Irina Pleines, David J. J. de Gorter, Mathias Müsken, Jan Faix, Robert Geffers
The hematopoietic-specific protein 1 (Hem1) comprises an essential subunit of the WAVE Regulatory Complex (WRC) in immune cells. WRC has a fundamental role in Arp2/3 complex activation and the protrusion of branched actin networks in motile cells.Hem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7319326500e49662ff240e32ac288401
https://doi.org/10.1101/2020.03.24.005835
https://doi.org/10.1101/2020.03.24.005835
Publikováno v:
Swiss Medical Weekly.
Although the impact of osteoblast-osteoclast crosstalk in bone remodelling has been intensively studied, the importance of osteocytes, descendants of osteoblasts, in this process has for a long time been neglected. During their embedding phase, osteo
Publikováno v:
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Autor:
Thomas Pap, Peter Paruzel, Berno Dankbar, David J. J. de Gorter, Michelle Fennen, Johanna Intemann, V Kracke, E Werbenko
Publikováno v:
Abstracts.
Career situation of first and presenting author Student for a master or a PhD. Introduction Activins and inhibins belong to the transforming growth factor β family. Activins are disulphide-linked homo- or heterodimers consisting of two inhibin β ch
Autor:
Corinna Wehmeyer, V Kracke, Thomas Pap, Johanna Intemann, Michaela Kneissel, David J. J. de Gorter, Ina Kramer, Berno Dankbar, Peter Paruzel
Publikováno v:
Abstracts.
Career situation of first and presenting author Student for a master or a PhD. Introduction Sclerostin is a Wnt inhibitor and has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation. Sclerostin loss-of-function