Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David J. Haydon"'
Autor:
Jessica K. Calland, Maiju E. Pesonen, Jai Mehat, Ben Pascoe, David J. Haydon, Jose Lourenco, Barbara Lukasiewicz, Evangelos Mourkas, Matthew D. Hitchings, Roberto M. La Ragione, Philip Hammond, Timothy S. Wallis, Jukka Corander, Samuel K. Sheppard
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Campylobacter is a leading cause of food-borne gastroenteritis worldwide, linked to the consumption of contaminated poultry meat. Targeting this pathogen at source, vaccines for poultry can provide short-term caecal reductions in Campylobact
Externí odkaz:
https://doaj.org/article/8077fca5c18f487b838dfa77bd6a688e
Autor:
Herve Migaud, L. Smith, Alexandra Adams, David J Haydon, David W. Verner-Jeffreys, Timothy S. Wallis, Jose Gustavo Ramirez-Paredes, Athina Papadopoulou, Sean J. Monaghan, Andrew Davie
Publikováno v:
Ramirez-Paredes, J G, Verner-Jeffreys, D W, Papadopoulou, A, Monaghan, S J, Smith, L, Haydon, D, Wallis, T S, Davie, A, Adams, A & Migaud, H 2020, ' A commercial autogenous injection vaccine protects ballan wrasse (Labrus bergylta, Ascanius) against Aeromonas salmonicida vapA type V ', Fish and Shellfish Immunology, vol. 107, no. Pt A, pp. 43-53 . https://doi.org/10.1016/j.fsi.2020.09.040
Atypical Aeromonas salmonicida (aAs) and Vibrionaceae related species are bacteria routinely recovered from diseased ballan wrasse used as cleaner fish in the Atlantic salmon farming industry. Autogenous (i.e. farm specific inactivated) multivalent v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcf126c859ad00c38aabd545f1e988d
https://hdl.handle.net/20.500.11820/81e3c982-c02b-4c12-bd1a-13dd7798286f
https://hdl.handle.net/20.500.11820/81e3c982-c02b-4c12-bd1a-13dd7798286f
Autor:
William Hunt, Emanuel K Pecku, David M. Stone, Richard Paley, Peter A. Ziddah, David J Haydon, Joshua Gray, James Guilder, Mary Nkansa, Terence R Field, Samuel Duodu, David W. Verner-Jeffreys, Joseph A Awuni, Jose Gustavo Ramirez-Paredes, Timothy S. Wallis, Stephen W. Feist
Publikováno v:
Transboundary and Emerging Diseases
SummaryIn late 2018, unusual patterns of very high mortality (>50% production) were reported in intensive tilapia cage culture systems across Lake Volta in Ghana. Samples of fish and fry were collected and analysed from two affected farms between Oct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29cb511ac760f475c2eff1ad774830f
https://doi.org/10.1101/680538
https://doi.org/10.1101/680538
Autor:
I Cano Cejas, Gareth Wood, J Dontwi, D Adjei-Boteng, David J Haydon, S W Feist, T R Field, Tim P. Bean, David W. Verner-Jeffreys, J F Domazoro, T J Wallis, David Ryder
Publikováno v:
Journal of fish diseases. 41(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c4face0b3a685ecd0c04186580f30d
https://pubmed.ncbi.nlm.nih.gov/28745405
https://pubmed.ncbi.nlm.nih.gov/28745405
Autor:
Alastair Logan, James T Palmer, B. Narasinga Rao, Neil R. Stokes, Ian Collins, Tarun Shukla, James M. Bennett, Anil K Srivastava, Paul Lancett, Leigh Ford, Pitt Gary Robert William, Helena Thomaides-Brears, Lorraine C. Axford, Stephanie Barker, Anju Yadav, Amit Kumar Singh, David T. Davies, Michael Blair, Craig J. Morton, David J. Haydon, Carlie T. Gannon, Daniel A. Offermann, Christopher J. Lunniss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4215-4222
A series of dual-targeting, alcohol-containing benzothiazoles has been identified with superior antibacterial activity and drug-like properties. Early lead benzothiazoles containing carboxylic acid moieties showed efficacy in a well-established in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56375c1a64d7f34eec61285f25026252
https://doi.org/10.1016/j.bmcl.2014.07.037
https://doi.org/10.1016/j.bmcl.2014.07.037
Autor:
Ian Collins, Pramod K. Chauhan, Neil R. Stokes, Anu Mahajan, Anil K Srivastava, Mahipal Singh, Anju Yadav, James M. Bennett, Leanne MacLeod, Paul Lancett, Yashodanand Nandan Nayal, David T. Davies, Narendra Nayal, Maruti Gavade, David J. Haydon, Rebecca Macdonald, Nicola Baker, Jeffrey Peter Mitchell, Lloyd George Czaplewski, Pitt Gary Robert William, Dushyant Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:353-359
The design, synthesis and structure-activity relationships of a series of oxazole-benzamide inhibitors of the essential bacterial cell division protein FtsZ are described. Compounds had potent anti-staphylococcal activity and inhibited the cytokinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddbd9a97bd9de9b500efee80df242b4
https://doi.org/10.1016/j.bmcl.2013.11.002
https://doi.org/10.1016/j.bmcl.2013.11.002
Autor:
Jeffrey Peter Mitchell, David J. Haydon, Hilary Peasley, Lloyd George Czaplewski, Narendra Nayal, Alastair Logan, Joanne Berry, Anil K. Srivastava, Anju Yadav, Ian Collins, Neil R. Stokes, James M. Bennett, Rebecca Macdonald, Nicola Baker, Leanne MacLeod
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:317-325
The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have been reported to be potent and selective antistaphylococcal agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9b083bc874958b03fddf8bb95cf0f
https://doi.org/10.1128/aac.01580-12
https://doi.org/10.1128/aac.01580-12
Autor:
JamesM. Bennett, Ian Collins, Lloyd George Czaplewski, David J. Haydon, Rebecca Macdonald, Pramod K. Chauhan, David A. Brown, Vincent Henstock, Neil R. Stokes, Greta Galbraith, Robin Hall, Anil K Srivastava, Paul Lancett, Joy Beanland, Caterina Noula, Narendra Nayal, Jignesh K. Sutariya, Chris Rockley
Publikováno v:
Journal of Medicinal Chemistry
3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0617fb320dd9003dcf03b3aefd312
https://doi.org/10.1021/jm9016366
https://doi.org/10.1021/jm9016366
Autor:
Konstantinos Papadopoulos, Paul Lancett, E.Andrew Boyd, Ian Collins, Stuart Hatcher, Brian Dymock, Paul N. Mortenson, Stephanie Barker, Chandana Chowdhury, Peter Ingram, Stephen P. East, Clara Bantry White, James Workman, Christopher James Brennan, David Brown, Jim Bennett, Rowena Fletcher, Oliver Barker, Carol Smee, Emmanuelle Convers-Reignier, Mihaly Gardiner, Lloyd George Czaplewski, David J. Haydon, Helena Thomaides-Brears, Heather Tye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:894-899
The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd89849d8c7c9d819089fad0a79b88d8
https://doi.org/10.1016/j.bmcl.2008.11.102
https://doi.org/10.1016/j.bmcl.2008.11.102
Autor:
Amit Taneja, Patrick J. Baker, Greta Galbraith, James M. Bennett, David Brown, Rebecca Ure, Ian Collins, Sachin T. Aiwale, Neil R. Stokes, Joseph M. Sheridan, Anil K. Srivastava, Jeff Errington, Lloyd George Czaplewski, David J. Haydon, Jonathan R. Heal, Pramod K. Chauhan, David W. Rice, Sveta Sedelnikova, V.V. Barynin
Publikováno v:
Science. 321:1673-1675
FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian β-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of small synthetic antibacterials, exemplified by PC190723, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c087d2b0be909f5021ad260fae5e4867
https://doi.org/10.1126/science.1159961
https://doi.org/10.1126/science.1159961