Transient Elastography in Community Alcohol Services: Can It Detect Significant Liver Disease and Impact Drinking Behaviour?

Autor: Mohsan Subhani, David J. Harman, Robert A. Scott, Lucy Bennett, Emilie A. Wilkes, Martin W. James, Guruprasad P. Aithal, Stephen D. Ryder, Indra Neil Guha

Publikováno v: Biomedicines, Vol 10, Iss 2, p 477 (2022)

Introduction: Alcohol is the leading cause of cirrhosis in Western populations. The early identification of high-risk drinkers followed by intervention is an effective way to reduce harm. We aim to assess the feasibility of integrating transient elas

Externí odkaz: https://doaj.org/article/836e893a1c7e4df2b782a30f3cb08564

Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation

Autor: Holly Knight, Joanne R Morling, David J. Harman, Guruprasad P. Aithal, Manpreet Bains, Indra Neil Guha, Timothy R. Card

Publikováno v: BMJ Open
BMJ Open, Vol 10, Iss 11 (2020)

ObjectivesThe increasing incidence of chronic liver disease (CLD) in the UK may be attributed to a rise in preventable risk factors, including hazardous alcohol use and type 2 diabetes. Transient elastography (TE) can rapidly stratify risk of CLD in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6347a313f55d7ae6a1e8182bafe716e
http://europepmc.org/articles/PMC7677335

Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review

Autor: Timothy R. Card, Guruprasad P. Aithal, Rebecca Harris, Indra Neil Guha, David J. Harman

Publikováno v: The Lancet Gastroenterology & Hepatology. 2:288-297

Summary As of 2016, there is no evidence-based pathway to stratify the risk of chronic liver disease in a general population setting. Non-invasive tests of liver fibrosis might provide a mechanism for earlier diagnosis. These tests have been extensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dbaa35e77e1c76d7efd029635ffd1d
https://doi.org/10.1016/s2468-1253(16)30205-9

Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia

Autor: Paolo Angeli, Vincent Wai-Sun Wong, Carmen Expósito, Indra Neil Guha, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Torán, Llorenç Caballería, Isabel Graupera, A Arslanow, Núria Fabrellas, Miquel Serra-Burriel, Rosario Hernández, Maja Thiele, David J. Harman, Peter R. Galle, Grace Lai-Hung Wong, Dominique Roulot, Sarwa Darwish Murad, Guillem Pera, Pere Ginès, Guruprasad P. Aithal

Publikováno v: Journal of Hepatology, 71(6), 1141-1151. Elsevier
Journal of Hepatology
Serra-Burriel, M, Graupera, I, Torán, P, Thiele, M, Roulot, D, Wai-Sun Wong, V, Neil Guha, I, Fabrellas, N, Arslanow, A, Expósito, C, Hernández, R, Lai-Hung Wong, G, Harman, D, Darwish Murad, S, Krag, A, Pera, G, Angeli, P, Galle, P, Aithal, G P, Caballeria, L, Castera, L, Ginès, P, Lammert, F & investigators of the LiverScreen Consortium 2019, ' Transient elastography for screening of liver fibrosis : Cost-effectiveness analysis from six prospective cohorts in Europe and Asia ', Journal of Hepatology, vol. 71, no. 6, pp. 1141-1151 . https://doi.org/10.1016/j.jhep.2019.08.019

Background & Aims: Non-alcoholic fatty liver disease and alcohol-related liver disease pose an important challenge to current clinical healthcare pathways because of the large number of at-risk patients. Therefore, we aimed to explore the cost-effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf593d7a50b7aa3e0ae3af85cad77ce
http://hdl.handle.net/10230/46634

Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using transient elastography

Autor: Guruprasad P. Aithal, Stephen D. Ryder, Emilie Wilkes, David J. Harman, Indra Neil Guha, Timothy R. Card, Martin W. James

Publikováno v: Alimentary pharmacologytherapeutics. 47(4)

Background: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as type 2 diabetes and obesity may also be important. Aim: To screen at-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e810b1a22f3e961643d58c2e9e361c3
https://pubmed.ncbi.nlm.nih.gov/29417625