Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David J. Graber"'
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unclear etiology and few treatment options. Engineering of human cells for therapy has great potential to provide a means to create long-lived therapeutics that can r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bdef0ce027a4b40c38a8c6f3761ed2d
https://doi.org/10.1101/2021.09.27.461982
https://doi.org/10.1101/2021.09.27.461982
Publikováno v:
Best Practice & Research Clinical Haematology. 31:176-183
Chimeric antigen receptors (CAR)-T cell therapy has recently made promising advances towards treatment of B-cell malignancies. This approach makes use of an antibody-derived single chain variable fragment (scFv)-based CAR to target the CD19 antigen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf72b313fe6b96cb3ad154adb1d02a7
https://doi.org/10.1016/j.beha.2018.03.003
https://doi.org/10.1016/j.beha.2018.03.003
Autor:
Marie-Louise Sentman, Benjamin Demoulin, David E Gilham, Caroline Lonez, Sophie Agaugue, W. James Cook, Charles L Sentman, David J. Graber, Joana M. Murad
Publikováno v:
Future Oncology. 13:1593-1605
Chimeric antigen receptors (CARs) are genetically engineered proteins that combine an extracellular antigen-specific recognition domain with one or several intracellular T-cell signaling domains. When expressed in T cells, these CARs specifically tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb694966a9118c270f6707fe7684100d
https://doi.org/10.2217/fon-2017-0102
https://doi.org/10.2217/fon-2017-0102
Publikováno v:
Discovery medicine. 22(119)
Autoimmune disorders are long-term diseases that adversely affect the quality of life for patients, and they are one of the top ten leading causes of death. While each autoimmune disorder is unique, they all are caused by a breakdown of tolerance aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::406af7bc7ce9148167725e4f79b2ef71
https://pubmed.ncbi.nlm.nih.gov/27585233
https://pubmed.ncbi.nlm.nih.gov/27585233
Publikováno v:
Journal of Neuroimmune Pharmacology. 7:266-278
Limiting excessive production of inflammatory mediators is an effective therapeutic strategy for many diseases. It's also a promising remedy for neurodegenerative diseases and central nervous system (CNS) injuries. Glucocorticoids are valuable anti-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ec9e0fe5f02093738ebde78cee5fb0
https://doi.org/10.1007/s11481-011-9338-8
https://doi.org/10.1007/s11481-011-9338-8
Autor:
Robert A. Maue, Brent T. Harris, Ivan A. Borbon, Christine M. Wooley, Maximillian A. Rogers, David J. Graber, Catherine C.Y. Chang, Robert W. Burgess, Leslie P. Henderson, Robert P. Erickson, Theodore P. Trouard, Marie T. Vanier, Carlos A. A. Penatti, Kevin L. Seburn, Bing Wang, John Totenhagen, Benjamin S. Szwergold, Ta-Yuan Chang, Donna M. Porter
Publikováno v:
Human Molecular Genetics. 21:730-750
We have identified a point mutation in Npc1 that creates a novel mouse model (Npc1(nmf164)) of Niemann-Pick type C1 (NPC) disease: a single nucleotide change (A to G at cDNA bp 3163) that results in an aspartate to glycine change at position 1005 (D1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3183f2b0e75b63b8fff7fd0c1c1717d6
https://doi.org/10.1093/hmg/ddr505
https://doi.org/10.1093/hmg/ddr505
Autor:
Jacqueline Y. Channon Smith, Christopher H. Cogbill, Linda Kingman, Elijah W. Stommel, Camilo E. Fadul, Todd Mackenzie, Jeffrey A. Cohen, David J. Graber, Brent T. Harris
Publikováno v:
Amyotrophic Lateral Sclerosis. 10:393-404
Neuroinflammation through the cytokine, tumor necrosis factor-alpha (TNF-alpha) is thought to play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). We conducted a preliminary phase II trial of thalidomide, which reduces l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9feafa524c30e4911f91df573416036
https://doi.org/10.3109/17482960802709416
https://doi.org/10.3109/17482960802709416
Publikováno v:
Synapse. 62:487-500
Organotypic cocultures of striatum, cortex, and ventral mesencephalon were used to study the anatomical and physiological development of striatal neurons in the presence or absence of cortical and nigral (SN/VTA) inputs. Striatum and cortex were diss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d17d94a050ba266cce8ae4e9424bf2
https://doi.org/10.1002/syn.20518
https://doi.org/10.1002/syn.20518
Publikováno v:
Journal of Neuroinflammation
Background The immunological response during the first 24 hours after traumatic brain injury (TBI) may be a critical therapeutic interval for limiting the secondary neuronal damage that is influenced by enhanced inflammatory mediator expression. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16564e417ea3da15e4713aa9f0520df
https://doi.org/10.1186/s12974-015-0298-4
https://doi.org/10.1186/s12974-015-0298-4
Publikováno v:
Langmuir. 19:5431-5434
The ability to pattern functional biomolecules onto surfaces at the micrometer scale is critical to a large number of important biological methods. Since devices such as microarrays and biosensors, or surfaces for generation of complex cellular netwo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7e69aad6981b9b3fb4117117235c9f
https://doi.org/10.1021/la034199f
https://doi.org/10.1021/la034199f