Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David J. Gillooly"'
Publikováno v:
Journal of Cell Biology. 155:15-18
Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturati
Publikováno v:
Journal of Biological Chemistry. 275:24595-24600
FYVE zinc finger domains, which are conserved in multiple proteins from yeast to man, interact specifically with the membrane lipid phosphatidylinositol 3-phosphate (PtdIns(3)P). Here we have investigated the structural requirements for the interacti
Autor:
Janet M. Allen, David J. Gillooly, Margaret M. Harnett, Austin R. Hockaday, Alirio J. Melendez
Publikováno v:
Biochemical Journal. 344:605-611
FcgammaRI, the human high-affinity IgG receptor, is responsible for the internalization of immune complexes and their subsequent targetting to the lysosomes for degradation. We show here that aggregation of FcgammaRI by surface immune complexes in in
Publikováno v:
Biochemical Society Transactions. 27:666-670
40 Auger, K, Serunian, L A., Soltofl S. P., Libby, P. and Cantley, Vanhaesebroeck B., Gout, I., Panayotou, G., Domin, J., Stein, R, Pages, F. et al. ( I 996) Philos. Trans. R SOC. London B 35 I , 2 17-223 38 Volinia, S., Dhand, R, Vanhaesebroeck B.,
Publikováno v:
Proceedings of the National Academy of Sciences. 95:2169-2174
Phosphoinositide 3-kinases (PI3-kinases) play an important role in the generation of lipid second messengers and the transduction of a myriad of biological responses. Distinct isoforms have been shown to be exclusively activated either by tyrosine ki
Autor:
Charles A. Fewson, David J. Gillooly
Publikováno v:
Biotechnology Letters. 20:325-327
Benzyl alcohol dehydrogenase from Acinetobacter calcoaceticus oxidises a wide range of aromatic and other cyclic alcohols and it has high specificity constants for these substrates, but it does not oxidise short- or long-chain aliphatic alcohols. Mut
Autor:
Harald Stenmark, Anne Simonsen, David J. Gillooly, Noboru Mizushima, Hanne C.G. Birkeland, Thomas Slagsvold, Akiko Kuma, Tamotsu Yoshimori, Andreas Brech
Publikováno v:
Journal of cell science. 117(Pt 18)
Phosphatidylinositol-3-phosphate [PtdIns(3)P] regulates endocytic and autophagic membrane traffic. In order to understand the downstream effects of PtdIns(3)P in these processes, it is important to identify PtdIns(3)P-binding proteins, many of which
Autor:
Harald Stenmark, Bianca Habermann, Alicia Cabezas, David J. Gillooly, Fedor F. Severin, Anja Runge, Marino Zerial, Sebastian Hoepfner
Publikováno v:
Cell. 121(3)
SummaryDifferent classes of endosomes exhibit a characteristic intracellular steady-state distribution governed by interactions with the cytoskeleton. We found a kinesin-3, KIF16B, that transports early endosomes to the plus end of microtubules in a
Publikováno v:
Histochemistry and cell biology. 120(6)
Phosphatidylinositol 3-phosphate [PI(3)P] is a phosphatidylinositol 3-kinase product whose localisation is restricted to the limiting membranes of early endosomes and to the internal vesicles of multivesicular bodies. In this study the intracellular
Autor:
Camilla Raiborg, Kristi G. Bache, Inger Helene Madshus, David J. Gillooly, Harald Stenmark, Espen Stang
Publikováno v:
Nature cell biology. 4(5)
After endocytosis, some membrane proteins recycle from early endosomes to the plasma membrane whereas others are transported to late endosomes and lysosomes for degradation1. Conjugation with the small polypeptide ubiquitin is a signal for lysosomal