Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David J. Forsthoefel"'
Autor:
Lily L. Wong, Christina G. Bruxvoort, Nicholas I. Cejda, Matthew R. Delaney, Jannette Rodriguez Otero, David J. Forsthoefel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Lipid metabolism regulates stem cell states and differentiation. Here, the authors demonstrate a requirement in planarians for Apolipoprotein B-mediated neutral lipid transport from intestinal stores to stem cells and their progeny during differentia
Externí odkaz:
https://doaj.org/article/1e5027e1b8fb46e9980387d043d0b68a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Regeneration requires cellular proliferation, differentiation, and other processes that are regulated by secreted cues originating from cells in the local environment. Recent studies suggest that signaling by extracellular vesicles (EVs), another mod
Externí odkaz:
https://doaj.org/article/b14bbf4052424747bf1b78c009936f91
Publikováno v:
eLife, Vol 9 (2020)
Proper function and repair of the digestive system are vital to most animals. Deciphering the mechanisms involved in these processes requires an atlas of gene expression and cell types. Here, we applied laser-capture microdissection (LCM) and RNA-seq
Externí odkaz:
https://doaj.org/article/ff49e0917861474d8325cb12398203a9
Regeneration requires remodeling of pre-existing structures and their integration with new cells and tissue. Identification of injury-induced regulators of these processes is central to regenerative biology. In planarian flatworms, the intestine remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0126ef29e08be83d81d92ccb25332ae7
https://doi.org/10.1101/2023.03.23.533990
https://doi.org/10.1101/2023.03.23.533990
Autor:
Lily L. Wong, David J. Forsthoefel, Christina G. Bruxvoort, Nicholas I. Cejda, Jannette Rodriguez Otero
Lipid metabolism plays an instructive role in regulating stem cell state and differentiation. However, the roles of lipid mobilization and utilization in stem cell-driven regeneration are unclear. Planarian flatworms readily restore missing tissue du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5dc4dd69f57926ca026871e34324f9
https://doi.org/10.1101/2021.03.04.433904
https://doi.org/10.1101/2021.03.04.433904
Organ regeneration requires precise coordination of new cell differentiation and remodeling of uninjured tissue to faithfully re-establish organ morphology and function. An atlas of gene expression and cell types in the uninjured state is therefore a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b07508834f4dafb1380bf54ad5b7bf4
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781493978007
Methods in Molecular Biology ISBN: 9781493978007
Efforts to elucidate mechanisms of regeneration in the planarian Schmidtea mediterranea have included the application of immunocytochemical methods to detect specific molecules and label cells and tissues in situ. Here we describe methods for immunof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5698527bc57afeac4ac2a03af657816
https://europepmc.org/articles/PMC8444624/
https://europepmc.org/articles/PMC8444624/
Autor:
Norito Shibata, Jennifer A. Weiss, David J. Forsthoefel, Hayoung Lee, Takeshi Inoue, Phillip A. Newmark, Kiyokazu Agata, Labib Rouhana, Ryan S. King
Publikováno v:
Developmental Dynamics. 242:718-730
Background The ability to assess gene function is essential for understanding biological processes. Currently, RNA interference (RNAi) is the only technique available to assess gene function in planarians, in which it has been induced by means of inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9303c49b777d035d093bbe42bd45d86
https://doi.org/10.1002/dvdy.23950
https://doi.org/10.1002/dvdy.23950
Autor:
Xiaodong Feng, Ramiro Iglesias-Bartolome, José P. Vaqué, Qianming Chen, J. Silvio Gutkind, Bruce R. Ksander, Hidemi Teramoto, Mark A. Seeger, Robert T. Dorsam, Anne Debant, David J. Forsthoefel
Publikováno v:
Molecular Cell. 49:94-108
Summary Activating mutations in GNAQ and GNA11 , encoding members of the Gα q family of G protein α subunits, are the driver oncogenes in uveal melanoma, and mutations in Gq-linked G protein-coupled receptors have been identified recently in numero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a19b7d815d37a05a90f8da7c92cd1c
https://doi.org/10.1016/j.molcel.2012.10.018
https://doi.org/10.1016/j.molcel.2012.10.018