Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David J. Fontana"'
Autor:
Alvin V. Terry, David J. Fontana, William J. Jackson, Jerry J. Buccafusco, Douglas W. Bonhaus, Paul Weller, E.H.F. Wong, Mark A. Prendergast, Richard M. Eglen
Publikováno v:
Psychopharmacology. 135:407-415
Recent evidence indicates that the 5-HT4 subtype of serotonin receptor may modulate central cholinergic activity in regions of the mammalian CNS important to memory such as the frontal cortex, hippocampus and amygdala. These receptors could represent
Autor:
R. Secchi, David J. Fontana, Richard M. Eglen, Linda Hedley, J. Sutton, R. E. Link, R. Lewis, Jeffrey R. Jasper, John C. Hunter
Publikováno v:
British Journal of Pharmacology. 122:1339-1344
1. The role of alpha2-adrenoceptor (AR) subtypes in the modulation of acute nociception, motor behaviour and body temperature, has been investigated by determining the activity of the alpha2AR selective agonist dexmedetomidine (Dex) in mice devoid of
Autor:
L. Wong, Richard M. Eglen, Z. Cao, M. Taylor, Douglas W. Bonhaus, K. K. Weinhardt, M. W. Dawson, P. M. McNeeley, A. DeSouza, David J. Fontana, C. L. Rocha, K. Szczepanski, J. Trinh
Publikováno v:
CNS Drug Reviews. 3:278-293
Autor:
Karen Chen, William C. Mobley, Scott E. Daniels, Randolph M. Johnson, Yuling Sun, Enrico Alleva, Elaine J. Carlson, Charles J. Epstein, David M. Holtzman, David J. Fontana, Daniela Santucci, Jane Chua-Couzens, Joshua Kilbridge
Publikováno v:
Proceedings of the National Academy of Sciences. 93:13333-13338
To study the pathogenesis of central nervous system abnormalities in Down syndrome (DS), we have analyzed a new genetic model of DS, the partial trisomy 16 (Ts65Dn) mouse. Ts65Dn mice have an extra copy of the distal aspect of mouse chromosome 16, a
Autor:
David J. Fontana, E.H.F. Wong, Scott E. Daniels, C.-H. Lee, M. Khabbaz, Richard M. Eglen, T. Kilfoil
Publikováno v:
Neuropharmacology. 33:227-234
The inhibitory effects of ondansetron and R and S zacopride on aversive behavior to light and the von Bezold-Jarisch reflex have been compared in mouse. The potencies (ID 50 , μg/kg i.v.) of compounds at inhibiting the von Bezold-Jarisch reflex, eli
Autor:
Donna M. Ellis, Diane M. Schefke, Timothy J. Hill, Catherine A. Becker, David J. Fontana, Randall L. Commissaris
Publikováno v:
Pharmacology Biochemistry and Behavior. 37:167-176
The present studies examined the effects of chronic treatment with several antidepressants and clonidine on conflict behavior. In daily ten-minute sessions, water-deprived rats were trained to drink from a tube which was occasionally electrified (0.2
Autor:
Linda Hedley, Laura Kassotakis, John C. Hunter, Kathleen Ruth Gogas, David J. Fontana, Julie Thompson, Lupita Jacobson
Publikováno v:
European journal of pharmacology. 324(2-3)
The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models. Lamotrigine (10-100 mg/kg, s.c.),
Autor:
M. Taylor, C. L. Rocha, P. M. McNeeley, Flippin Lee Allen, David J. Fontana, Douglas W. Bonhaus, K. K. Weinhardt, M. W. Dawson, J. Trinh, A. DeSouza, Richard M. Eglen, K. Szczepanski
Publikováno v:
Neuropharmacology. 36(4-5)
The 5-HT2C receptor is one of three closely related receptor subtypes in the 5-HT2 receptor family. 5-HT2A and 5-HT2B selective antagonists have been described. However, no 5-HT2C selective antagonists have yet been disclosed. As part of an effort to
Autor:
Pamela L. Clemens, John A. Thompson, Patrick Hwu, David J. Fontana, Christoph Matthias Ahlers, Jon M. Wigginton, Michael S. Gordon, Rachel Bittner, Shailender Bhatia, Lewis J. Cohen, Nels Royer, Brendan D. Curti, Jason Chesney, Theodore F. Logan, Joseph F. Grosso
Publikováno v:
Journal of Clinical Oncology. 31:TPS3109-TPS3109
TPS3109 Background: Ipilimumab is a monoclonal anti-CTLA-4 antibody that promotes T-cell activation and has been approved for the treatment of pts with advanced melanoma. The cytokine rIL-21 is a T-cell and NK-cell growth factor that has also demonst