Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David J. Foltz"'
Autor:
David J. Foltz, Helga Rothe, Cindy Obringer, Timothy R. Baker, John Manwaring, Carsten Goebel, Nicola J. Hewitt, John A. Troutman
Publikováno v:
Toxicology and applied pharmacology. 287(2)
Approaches to assess the role of absorption, metabolism and excretion of cosmetic ingredients that are based on the integration of different in vitro data are important for their safety assessment, specifically as it offers an opportunity to refine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1523bd9d65d22f1283b979951bbc9a
https://pubmed.ncbi.nlm.nih.gov/26028483
https://pubmed.ncbi.nlm.nih.gov/26028483
Autor:
David J. Foltz, Roger G. Bookland, Fei Gu, Michael J. Janusz, Glen E. Mieling, Lily C. Hsieh, Todd M. Branch, Selane L. King, Matthew Pokross, Vikram S. Patel, Sean X. Peng, Staszek Pikul, Susan M. Garver, Matthew J. Laufersweiler, Biswanath De, Timothy R. Baker, Michael George Natchus, Neil Gregory Almstead
Publikováno v:
Journal of Medicinal Chemistry. 44:1060-1071
A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bf39acf42ba63cb73f32d78dec0c97
https://doi.org/10.1021/jm000477l
https://doi.org/10.1021/jm000477l
Autor:
Sean X. Peng, Michael George Natchus, Timothy R. Baker, Salane L. King, David J. Foltz, David M. Bornes
Publikováno v:
Analytical Chemistry. 72:1913-1917
Bioanalytical methods based on automated solid-phase extraction (SPE) and high-performance liquid chromatography with electrospray tandem mass spectrometry (LC-MS-MS) have been developed and utilized for the determination of MMP inhibitors in plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37129477080dadd43cc866d35fe97280
https://doi.org/10.1021/ac991349b
https://doi.org/10.1021/ac991349b
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 825(2)
The identification of in vitro and in vivo metabolites is vital to the discovery and development of new pharmaceutical therapies. Analytical strategies to identify metabolites at different stages of this process vary, but all involve the use of liqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ae46353da93b39960dc01f97386728
https://pubmed.ncbi.nlm.nih.gov/16213447
https://pubmed.ncbi.nlm.nih.gov/16213447
Autor:
Fei Gu, David M. Bornes, E.B. Hookfin, Glen E. Mieling, Matthew Pokross, Timothy R. Baker, Michael J. Strojnowski, Sandra A. Heitmeyer, Susan M. Garver, Stanislaw Pikul, David J. Foltz, Lily C. Hsieh, Vikram S. Patel, Michael George Natchus, Michael J. Janusz, Biswanath De, Sean X. Peng, Martin E. Dowty, Charles R. Dietsch, Neil Gregory Almstead, Yetunde Olabisi Taiwo, Roger G. Bookland
Publikováno v:
Journal of medicinal chemistry. 43(26)
A series of hydroxamates was prepared from an aminoproline scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f2a0b0432bdbaffa16d228b9204e8
https://pubmed.ncbi.nlm.nih.gov/11150165
https://pubmed.ncbi.nlm.nih.gov/11150165
Publikováno v:
Drug Metabolism Reviews. 2002 Supplement 1, Vol. 34, p12-12. 1/2p.
Publikováno v:
Drug Metabolism Reviews. 2002 Supplement 1, Vol. 34, p1-207. 207p.
Publikováno v:
Drug Metabolism Reviews. 2002 Supplement 1, Vol. 34, p12-12. 1/2p.