Zobrazeno 1 - 10
of 210
pro vyhledávání: '"David J. Fitzgerald"'
Autor:
Minsuk Kong, Domenico D’Atri, Maria Teresa Bilotta, Bailey Johnson, Taylor B. Updegrove, Devorah L. Gallardo, Federico Machinandiarena, I-Lin Wu, Maira Alves Constantino, Stephen M. Hewitt, Kandice Tanner, David J. Fitzgerald, Kumaran S. Ramamurthi
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111955- (2023)
Summary: Delivery of cancer therapeutics to non-specific sites decreases treatment efficacy while increasing toxicity. In ovarian cancer, overexpression of the cell surface marker HER2, which several therapeutics target, relates to poor prognosis. We
Externí odkaz:
https://doaj.org/article/98972d43a4eb4818a8c6cb579f199029
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The tumor microenvironment (TME) influences tumor growth, metastatic spread and response to treatment. Often immunosuppression, mediated by the TME, impairs a beneficial response. The complexity of the tumor composition challenges our abilities to de
Externí odkaz:
https://doaj.org/article/6c73d2dea6c34ac99cfe10063eeb2390
Publikováno v:
European Journal of Obstetrics & Gynecology and Reproductive Biology: X, Vol 1, Iss , Pp - (2019)
Objectives: To determine the infectious aetiology of peripartum maternal pyrexia and to assess the diagnostic accuracy of obstetric systemic inflammatory response syndrome criteria and cardiotocography as predictors of peripartum infection, in order
Externí odkaz:
https://doaj.org/article/159562d8af3a4a8fb1c99c88882cd09a
Autor:
Antonella Antignani, Eric Chun Hei Ho, Maria Teresa Bilotta, Rong Qiu, Robert Sarnvosky, David J. FitzGerald
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1331 (2020)
Cancer cells frequently upregulate surface receptors that promote growth and survival. These receptors constitute valid targets for intervention. One strategy involves the delivery of toxic payloads with the goal of killing those cancer cells with hi
Externí odkaz:
https://doaj.org/article/ebe9e00fc2fd429694b251004ea0fbef
PDF - 950KB, Legends for Supplementary Figures 1 and 2; Supplementary Figure 1: Screening of TK siRNA library; Supplementary Figure2: Src knock down slightly increased SS1P toxicity; Supplementary Table 1: Oligos used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a5e6da94d21d0671cb0e2e8d8e8ea
https://doi.org/10.1158/1535-7163.22504285
https://doi.org/10.1158/1535-7163.22504285
PDF - 65K, Loading controls of the cytosol and membrane fractions for the western blot shown in Fig 4A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b1bd768c87edcc6f9a613a31eebca4
https://doi.org/10.1158/1535-7163.22500495.v1
https://doi.org/10.1158/1535-7163.22500495.v1
Impaired apoptosis is often a key element in tumor development. Therefore, drugs mimicking prosurvival antagonists offer promise as cancer therapeutics. When ABT-737, a BH3-only mimetic, was added to KB3-1 human cervical adenocarcinoma cells, we note
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40706e814dd0b3d6cbe2d59f9d42d4ff
https://doi.org/10.1158/1535-7163.c.6536478.v1
https://doi.org/10.1158/1535-7163.c.6536478.v1
Autor:
Ira Pastan, Craig Thomas, Pinar Ormanoglu, Marco Prunotto, Paresma Patel, Scott Martin, David J. FitzGerald, Fatima Ali-Rahmani
Supplementary Methods Supplementary Reference Supplementary Figure Legends Supplementary Table Supplementary Figures Suppl Fig 1. Effect of DDR1 knockdown on internalization of alexa-647 labeled RG7787 Fig S2. Effect of DDR1 knockdown on mesothelin e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d651a3026efec4a346abe89d5d768a
https://doi.org/10.1158/0008-5472.22411323
https://doi.org/10.1158/0008-5472.22411323
Autor:
Ira Pastan, Craig Thomas, Pinar Ormanoglu, Marco Prunotto, Paresma Patel, Scott Martin, David J. FitzGerald, Fatima Ali-Rahmani
Recombinant immunotoxins (RIT) have been highly successful in cancer therapy due, in part, to the high cancer-specific expression of cell surface antigens such as mesothelin, which is overexpressed in mesothelioma, ovarian, lung, breast, and pancreat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af27416051cb4f6b6e6defa1a2e88e3
https://doi.org/10.1158/0008-5472.c.6508197.v1
https://doi.org/10.1158/0008-5472.c.6508197.v1
PDF file - 93K, Summary of the results of SS1P toxicity after IR knock down or addition of inhibitors in KB31 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0e02029dc04a347a564d135a5b75a4
https://doi.org/10.1158/0008-5472.22399002
https://doi.org/10.1158/0008-5472.22399002