Zobrazeno 1 - 10
of 51
pro vyhledávání: '"David J. Fischer"'
Autor:
Melanie S. Dugas, David J. Fischer, Selva Nataraja, Andreas Goutopoulos, Mathew Jenks, Foglesong Robert James, Henry Yu, Brian H. Heasley, Xuliang Jiang, Hui Tian, Thomas F. N. Haxell, Jane Li, Pandi Bharathi, Venkataraman Sriraman, Thomas E. Richardson, Stephen S. Palmer, Regina Collis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2168-2172
Follicle-stimulating hormone (FSH), acting on its receptor (FSHR), plays a pivotal role in the stimulation of follicular development and maturation. Multiple injections of protein formulations are used during clinical protocols for ovulation inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa9b8a7a58d2835c548c1632fd29765
https://doi.org/10.1016/j.bmcl.2014.03.018
https://doi.org/10.1016/j.bmcl.2014.03.018
Autor:
Xuliang Jiang, Henry Yu, Xiaolin He, Po Han Chen, Venkataraman Sriraman, Steve Arkinstall, Xiaoyan Chen, Heli Liu, David J. Fischer
Publikováno v:
Proceedings of the National Academy of Sciences. 109:12491-12496
FSH, a glycoprotein hormone, and the FSH receptor (FSHR), a G protein-coupled receptor, play central roles in human reproduction. We report the crystal structure of FSH in complex with the entire extracellular domain of FSHR (FSHR ED ), including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810f7b88d427399c2f51232bb63843ef
https://doi.org/10.1073/pnas.1206643109
https://doi.org/10.1073/pnas.1206643109
Publikováno v:
ZDM. 44:761-773
We report on one aspect of an extended research and development project that was conducted to support teachers’ development of mathematical knowledge for teaching (MKT) algebra through participation and authentic engagement in online collaborative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478a9263463a92c60a6a71118894b1f7
https://doi.org/10.1007/s11858-012-0428-8
https://doi.org/10.1007/s11858-012-0428-8
Autor:
Srinivasa R. Karra, David J. Fischer, Yihua Liao, Adulla P. Reddy, Gian Luca Araldi, Elizabeth Palmer, Nadia Brugger, Zhong Zhao, Yufang Xiao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6572-6575
Replacement of the hydroxy cyclopentanone ring in PGE(2) with chemically more stable heterocyclic rings and substitution of the unsaturated alpha-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85c5453b1a391bf340148acce18b2fb
https://doi.org/10.1016/j.bmcl.2007.09.074
https://doi.org/10.1016/j.bmcl.2007.09.074
Autor:
David J. Fischer, Elizabeth Palmer, Nadia Brugger, Gian Luca Araldi, Zhong Zhao, Yufang Xiao, Srinivasa R. Karra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4323-4327
Analogs of PGE(2) with introduction of diene groups at the omega-side chain have been synthesized and evaluated for their binding affinity for EP(2) and EP(4) receptors. An optimized analog (compound 9b) showed high potency and selectivity for the EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b60f5adccbb805189a4472c44a679c4
https://doi.org/10.1016/j.bmcl.2007.05.025
https://doi.org/10.1016/j.bmcl.2007.05.025
Autor:
Kimberley L. Altobello, Thomas M. Ihley, Elena Ammannati, Enrico Gillio Tos, Cinzia Ciampolillo, Mckenna Sean D, David J. Fischer, Louise M. Garone, Angela Tiebout, Jiangping Luo, Emmi Kurosawa, Theresa S. Brush
Publikováno v:
Endocrinology. 147:4205-4212
A chimeric recombinant human gonadotropin, termed C3, demonstrates both follitropic and lutropic bioactivities. The alpha-subunit construct for C3 is comprised of the recombinant wild-type human glycoprotein hormone alpha-subunit. The beta-subunit DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b7e65ca0cc5385c6ef44775a25b315
https://doi.org/10.1210/en.2006-0354
https://doi.org/10.1210/en.2006-0354
Autor:
David J. Fischer, Sarah Spiegel, De-An Wang, Abby L. Parrill, James R. Van Brocklyn, Daniel L. Baker, Gabor Tigyi, Debra L. Bautista
Publikováno v:
Annals of the New York Academy of Sciences. 905:330-339
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3d1b00b2c28f1cd4ed4eae7f29b8f3
https://doi.org/10.1111/j.1749-6632.2000.tb06573.x
https://doi.org/10.1111/j.1749-6632.2000.tb06573.x
Publikováno v:
Electroanalysis. 17:1153-1159
The fabrication and evaluation of pyrolyzed photoresist films (PPF) for microchip capillary electrophoresis (CE) with dual-electrode electrochemical (EC) detection is described. The sensitivity, linearity, and reproducibility were evaluated using cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7333b60bfd8b9ac276e92b5701839ab0
https://doi.org/10.1002/elan.200503239
https://doi.org/10.1002/elan.200503239
Autor:
Enrico Gillio Tos, David J. Fischer, Bagna Bao, Mckenna Sean D, Michael Pietropaolo, David Kagan, Ann S. Clark, P. Jorge Chedrese, Stephen S. Palmer
Publikováno v:
Endocrinology. 146:208-214
Phosphodiesterases (PDEs) are a family of enzymes that hydrolyze cyclic nucleotides to render them biologically inactive. As such, these enzymes are critical regulators of signal transduction pathways that use cyclic nucleotides as second messengers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1fd44f5eda2805300a135d07cd86b0
https://doi.org/10.1210/en.2004-0562
https://doi.org/10.1210/en.2004-0562