Zobrazeno 1 - 10
of 40
pro vyhledávání: '"David J. Fear"'
Autor:
Yuan Zhao, Mohamed Uduman, Jacqueline H. Y. Siu, Thomas J. Tull, Jeremy D. Sanderson, Yu-Chang Bryan Wu, Julian Q. Zhou, Nedyalko Petrov, Richard Ellis, Katrina Todd, Konstantia-Maria Chavele, William Guesdon, Anna Vossenkamper, Wayel Jassem, David P. D’Cruz, David J. Fear, Susan John, Dagmar Scheel-Toellner, Claire Hopkins, Estefania Moreno, Natalie L. Woodman, Francesca Ciccarelli, Susanne Heck, Steven H. Kleinstein, Mats Bemark, Jo Spencer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despi
Externí odkaz:
https://doaj.org/article/18e17622ab574decbfaad7cce6011bef
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
IgE is secreted by plasma cells (PCs) and is central to allergic disease. Using an ex vivo tonsil B cell culture system, which mimics the Th2 responses in vivo, we have recently characterized the development pathway of human IgE-expressing PCs. In th
Externí odkaz:
https://doaj.org/article/da3d889f4da546bc8d590d847e27e32d
Phosphoinositide 3-kinase (PI3K) p110δ signalling negatively regulates the production of mouse IgE. However, there are disparities between the mouse and human IgE biology, and the role of PI3K p110δ in the production of human IgE is yet to be deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f697d4908ceed3ec23c5301adb04ea5e
https://doi.org/10.1101/2022.08.09.503316
https://doi.org/10.1101/2022.08.09.503316
Publikováno v:
Moore, T, Hossain, R, Doores, K J, Shankar-Hari, M & Flear, D J 2022, ' SARS-CoV-2-specific memory B cell responses are maintained after recovery from natural infection and post vaccination ', Viral Immunology, vol. 35, no. 6, pp. 425-436 . https://doi.org/10.1089/vim.2022.0013
Moore, T, Hossain, R, Doores, K J, Shankar-Hari, M & Fear, D J 2022, ' SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and Postvaccination ', Viral Immunology, vol. 35, no. 6, pp. 425-436 . https://doi.org/10.1089/vim.2022.0013
Moore, T, Hossain, R, Doores, K J, Shankar-Hari, M & Fear, D J 2022, ' SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and Postvaccination ', Viral Immunology, vol. 35, no. 6, pp. 425-436 . https://doi.org/10.1089/vim.2022.0013
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has resulted in major worldwide disruption and loss of life over the last 2 years. Many research studies have shown waning serological SARS-CoV-2-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a949b35ee5ad03ff9a93cc4f385d9763
https://www.pure.ed.ac.uk/ws/files/265532571/VIJ_Manuscript_Final.pdf
https://www.pure.ed.ac.uk/ws/files/265532571/VIJ_Manuscript_Final.pdf
Autor:
Merve Koc, Madison M. Lenormand, Wannada Laisuan, Gemma Vilà-Nadal, Kari C. Nadeau, Shoshanna Krasner-Macleod, Swati Acharya, Amy Switzer, Gopal Krishna R. Dhondalay, Hanisah Sharif, Yi Yi, Mohamed H. Shamji, Gilda Varricchi, Gianni Marone, Stephen R. Durham, Oleksandra Fedina, Rebecca Parkin, David J. Fear, Aarif O. Eifan, Guy W. Scadding, Elena Kashe
Background: Allergen-specific immunotherapy (AIT) is a disease-modifying treatment that induces long-term T cell tolerance. Objective: To evaluate the role of circulating CXCR5+ PD-1+. T follicular helper (cTFH) and T. follicular regulatory (TFR) cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c70df54f592a5e73cdb64191e3ce886
http://hdl.handle.net/11588/822321
http://hdl.handle.net/11588/822321
Autor:
William Guesdon, Michael J. Pitcher, Yuan Zhao, Cristina Lebrero-Fernández, Richard Groves, Wayel Jassem, Michelle Kleeman, Susanne Heck, Yogesh Kamra, David J. Fear, David D'Cruz, Richard Ellis, Susan D. John, Ulrich D. Kadolsky, Nedyalko Petrov, Pawan Dhami, Jeremy D. Sanderson, Thomas J Tull, Mats Bemark, Jacqueline Hy Siu, Jo Spencer, Michael D. Robson
Publikováno v:
Spencer, J, Tull, T, Pitcher, M, Guesdon, W, Siu, J HY, Lebraro-Fernandez, C, Zhao, Y, Petrov, N, Heck, S, Ellis, R, Dhami, P, kadolsky, U, Kleeman, M, Kamra, Y, Fear, D, John, S, Jassem, W, Groves, R, Sanderson, J D, Robson, M, D’Cruz, D & Bemark, M 2021, ' Human marginal zone B cell development from early T2 progenitors ', Journal of Experimental Medicine, vol. 218, no. 4, e20202001 . https://doi.org/10.1084/jem.20202001
The Journal of Experimental Medicine
The Journal of Experimental Medicine
This study identifies a developmental trajectory from human IgMhi gut homing transitional 2 cells to marginal zone B cells, all stages of which are affected in patients with severe systemic lupus erythematosus.
B cells emerge from the bone marro
B cells emerge from the bone marro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8c2c762c335e87f1bb70f46e6047e
https://doi.org/10.1101/2020.09.24.311498
https://doi.org/10.1101/2020.09.24.311498
Autor:
Khuloud T. Al-Jamal, Farid N. Faruqu, Yau M. Lim, Paul Lavender, Kee Y. Lim, Revadee Liam-or, Adam A. Walters, Claire M. Wells, Lizhou Xu, Julie Tzu-Wen Wang, David J. Fear
Publikováno v:
Biomaterials. 264
With a dismal survival rate, pancreatic cancer (PC) remains one of the most aggressive and devastating malignancies, predominantly due to the absence of a valid biomarker for diagnosis and limited therapeutic options for advanced diseases. Exosomes (
Autor:
Mohammad A. A. Ibrahim, David J. Fear, Terrence T.J. Hunter, Jo Spencer, Mark Peakman, Paul Lavender
Publikováno v:
Journal of immunological methods. 492
The Nuclear Factor Kappa B (NFκB) pathway is an important signalling pathway in the immune system. Single gene defects in the NFκB pathway are described in a number of immunodeficiency diseases. These conditions provide a unique opportunity to inve
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis
Autor:
David J. Fear, Tracey Mare, Jo Spencer, Manu Shankar-Hari, Mervyn Singer, Paul Lavender, Chad M. Swanson, Richard Beale
Publikováno v:
Shankar-Hari, M, Fear, D, Lavender, P, Mare, T, Beale, R, Swanson, C, Singer, M & Spencer, J 2017, ' Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis ', Critical Care Medicine, vol. 45, no. 5, pp. 875-882 . https://doi.org/10.1097/CCM.0000000000002380
OBJECTIVE: Sepsis is life-threatening organ dysfunction due to dysregulated host responses to infection. Current knowledge of human B-cell alterations in sepsis is sparse. We tested the hypothesis that B-cell loss in sepsis involves distinct subpopul
Autor:
Philip S. Hobson, David J. Cousins, Elizabeth H. Mann, David J. Fear, Timothy Recaldin, Faruk Ramadani, Paul Lavender
Publikováno v:
Recaldin, T, Hobson, P S, Mann, E H, Ramadani, F, Cousins, D J, Lavender, P & Fear, D J 2018, ' miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in naïve B cells ', Molecular Immunology, vol. 101, pp. 419-428 . https://doi.org/10.1016/j.molimm.2018.07.028
Class-switch recombination (CSR) is an essential B cell process that alters the isotype of antibody produced by the B cell, tailoring the immune response to the nature of the invading pathogen. CSR requires the activity of the mutagenic enzyme AID (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b01d1e9f5869f28deb7a04b6c53d582
https://kclpure.kcl.ac.uk/ws/files/99003161/miR_29b_directly_targets_activation_induced_RECALDIN_Accepted23July2018_GREEN_AAM_CC_BY_NC_ND_.pdf
https://kclpure.kcl.ac.uk/ws/files/99003161/miR_29b_directly_targets_activation_induced_RECALDIN_Accepted23July2018_GREEN_AAM_CC_BY_NC_ND_.pdf