Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David J. Earp"'
Autor:
Catherine E. Gleason, Pablo D. Garcia, Ranya Odeh, Frances Hamkins-Indik, Daphne He, Meisam Nosrati, Gavin Situ, Roberta Sala, Bernard Levin, Li-Fen Liu, Evelyn W. Wang, Siegfried Leung, Breena Fraga, Andrew T. Bockus, Justin Shapiro, Nathan Dupper, Chinmay Bhatt, Kai Yang, Megan DeMart, Sammy Metobo, James Aggen, Peadar Cremin, Ramesh Bambal, Constantine Kreatsoulas, David J. Earp, Rajinder Singh
Publikováno v:
Cancer Research. 83:1560-1560
RB and E2F genes are frequently altered in cancer. Cyclin/Cdk (cyclin-dependent kinase) complexes regulate the activity of RB and E2F to drive cell cycle progression and ensure fidelity of DNA replication. A critical subset of their substrates (Rb, E
Autor:
Shilpa Singh, Yavuz T. Durmaz, Catherine E. Gleason, Evelyn W. Wang, Rajinder Singh, David J. Earp, Pablo D. Garcia, Matthew G. Oser
Publikováno v:
Cancer Research. 83:1559-1559
Most cancer-directed targeted therapies are developed using small molecule inhibitors that require a druggable binding pocket on the target of interest. Macrocyclic peptides can selectively block protein-protein interactions required for function and
Autor:
Pablo D. Garcia, Catherine E. Gleason, Miles Membreno, Frances Hamkins-Indik, Gavin Situ, Bernard Levin, Evelyn W. Wang, Siegfried Leung, Breena Fraga, Andrew Bockus, James Aggen, David Spellmeyer, David J. Earp, Rajinder Singh
Publikováno v:
Cancer Research. 82:5379-5379
Inhibition of substrate binding to Cyclin A has been postulated to be synthetically lethal in retinoblastoma (Rb) mutated cancers (Chen et al 1999). While compounds that target the cyclin-associated kinases are approved for clinical use, attempts to
Autor:
Bhagyashree Khunte, Sangwoo Ryu, Jiangli Yan, Markus Boehm, Amit S. Kalgutkar, Kevin Beaumont, Janice A. Brown, Heather Eng, Laurie Tylaska, R. Scott Lokey, David Price, Elnaz Menhaji-Klotz, Chris Limberakis, Michael J. Shapiro, Guoyun Bai, Brian R. Holder, Liying Zhang, Sarah Lazzaro, Matthew P. Jacobson, Spiros Liras, David J. Earp, Alan M. Mathiowetz, Rhys M. Jones, Gilles H. Goetz, Siegfried S. F. Leung, Mahesh Ramaseshan, Rushia A. Turner, Karen Atkinson
Publikováno v:
Journal of medicinal chemistry. 60(23)
The chemokine receptor CXCR7 is an attractive target for a variety of diseases. While several small-molecule modulators of CXCR7 have been reported, peptidic macrocycles may provide advantages in terms of potency, selectivity, and reduced off-target
Publikováno v:
Nucleic acids research. 18(11)
The isolation of sequences flanking integrated transposable elements is an important step in gene tagging strategies. We have demonstrated that sequences flanking transposons integrated into complex genomes can be simply and rapidly obtained using th
Autor:
David J. Earp, David J. Ellar
Publikováno v:
FEMS Microbiology Letters. 52:29-32
Expression of the cloned 27 kDa toxin gene from Bacillus thuringiensis strain PG14 in Bacillus subtilis facilitated the evaluation of the in vivo and in vitro toxicities of the pure toxin. This toxin is known to differ from the 27 kDa δ-endotoxin of
Publikováno v:
FEMS Microbiology Letters. 42:195-199
The possible presence of protein δ-endotoxins with homology to a cloned mosquitocidal Bacillus thuringiensis var. israelensis δ-endotoxin was investigated in two other mosquitocidal B. thuringiensis strains. Antiserum raised against the var. israel