Zobrazeno 1 - 10
of 32
pro vyhledávání: '"David J. DiLillo"'
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
Corinne E. Decker, Jacqueline Idun, Katja Mohrs, Thomas Meagher, Kevin Bray, Iryna Petriv, Jonathon Golas, Timothy Helms, Dharani Ajithdoss, Gavin Thurston, John Lin, Jessica R. Kirshner, David J. DiLillo
Publikováno v:
Cancer Research. 83:1780-1780
The clinical success of cancer immunotherapy, including engineered T cell therapies, has revolutionized treatment paradigms and patient outcomes. While hematological tumors have benefited most from cell therapy approaches, the treatment of solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7dea29bd04e0c0dcbd3b655120b367
https://doi.org/10.1158/1538-7445.am2023-1780
https://doi.org/10.1158/1538-7445.am2023-1780
Autor:
Michael J. Moore, Maggie Zhong, Johanna Hansen, Hans Gartner, Craig Grant, Mei Huang, Faith M. Harris, Naxin Tu, Natalie A. Bowerman, Kurt H. Edelmann, Thomas Barry, Olivier Herbin, Chin-Siean Tay, David J. DiLillo, Corinne E. Decker, Natasha Levenkova, James Shevchuk, Ankur Dhanik, Karoline A. Meagher, Amanda Karr, Jan Roos, Wen-yi Lee, David Suh, Mark Eckersdorff, T. Craig Meagher, Matthew Koss, Lakeisha Esau, Matthew A. Sleeman, Robert Babb, Gang Chen, Christos A. Kyratsous, William T. Poueymirou, John R. McWhirter, Vera A. Voronina, Chunguang Guo, Cagan Gurer, George D. Yancopoulos, Andrew J. Murphy, Lynn E. Macdonald
Publikováno v:
Science Immunology. 6
Despite the enormous promise of T cell therapies, the isolation and study of human T cell receptors (TCRs) of dedicated specificity remains a major challenge. To overcome this limitation, we generated mice with a genetically humanized system of T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b33325698a8f3396e20dc96afc9308
https://doi.org/10.1126/sciimmunol.abj4026
https://doi.org/10.1126/sciimmunol.abj4026
Publikováno v:
Proceedings of the National Academy of Sciences. 115:12023-12027
The N-glycans attached to the Fab and Fc domains play distinct roles in modulating the functions of antibodies. However, posttranslational site-selective modifications of glycans in antibodies and other multiply glycosylated proteins remain a challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3c3d855a3d496758660d8590d961ae
https://doi.org/10.1073/pnas.1812833115
https://doi.org/10.1073/pnas.1812833115
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(40)
Ebola virus (EBOV) continues to pose significant threats to global public health, requiring ongoing development of multiple strategies for disease control. To date, numerous monoclonal antibodies (mAbs) that target the EBOV glycoprotein (GP) have dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530ad84d1aea43d3191f1142c7346ece
https://pubmed.ncbi.nlm.nih.gov/31484758
https://pubmed.ncbi.nlm.nih.gov/31484758
Publikováno v:
The Journal of Immunology. 204:170.24-170.24
Chimeric antigen receptor (CAR) T cell therapies have shown striking clinical efficacy in the treatment of hematological malignancies, but limited success so far against solid tumors, suggesting that solid tumors may harbor mechanisms of resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41434e3527ad09169326e6b1a38949f2
https://doi.org/10.4049/jimmunol.204.supp.170.24
https://doi.org/10.4049/jimmunol.204.supp.170.24
Autor:
Wei Ju, Sigrid Dubois, Zhengsheng Yao, David J. DiLillo, Richard N. Bamford, Meili Zhang, Olga M. Anton, Jeffrey V. Ravetch, Bernard Wen, Thomas A. Waldmann, Noriko Sato
Publikováno v:
Proceedings of the National Academy of Sciences. 115
The goal of cancer immunotherapy is to stimulate the host immune system to attack malignant cells. Antibody-dependent cellular cytotoxicity (ADCC) is a pivotal mechanism of antitumor action of clinically employed antitumor antibodies. IL-15 administe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb57f236b6bdd872269e45cf50b87bd
https://doi.org/10.1073/pnas.1811615115
https://doi.org/10.1073/pnas.1811615115
Autor:
Jeffrey V. Ravetch, David J. DiLillo
Publikováno v:
Cancer Immunology Research. 3:704-713
Antibodies are now recognized as key therapeutic tools to combat most forms of malignancy. Although the first wave of therapeutic antibodies that emerged over two decades ago directly target tumor cells for killing, a new class of antibody therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c0cf2e9758f4c76038576adaac6f8f
https://doi.org/10.1158/2326-6066.cir-15-0120
https://doi.org/10.1158/2326-6066.cir-15-0120
Publikováno v:
The Journal of Experimental Medicine
Bournazos, DiLillo, and Ravetch discuss the biology of Fc receptors and their contribution to the effector function of protective antibody responses during infections and in therapeutics.
Antibodies are bifunctional molecules, containing a varia
Antibodies are bifunctional molecules, containing a varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f778f37d2f9c387cb0a53cf2ddcbd0a
http://europepmc.org/articles/PMC4548051
http://europepmc.org/articles/PMC4548051
Autor:
Tiffany F. Chen, Stephen L. Sazinsky, David J. DiLillo, Julie Bird, Huawei Qiu, Kevin K. Li, John R. Engen, K. Dane Wittrup, Jeffrey V. Ravetch, Damian Houde, George T. Cheng
Publikováno v:
PMC
© 2017 Elsevier Ltd The binding of human IgG1 to human Fc gamma receptors (hFcγRs) is highly sensitive to the presence of a single N-linked glycosylation site at asparagine 297 of the Fc, with deglycosylation resulting in a complete loss of hFcγR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e211e3a765a22c223837394b25362cf
https://pubmed.ncbi.nlm.nih.gov/28694069
https://pubmed.ncbi.nlm.nih.gov/28694069