Zobrazeno 1 - 10
of 41
pro vyhledávání: '"David J. Davido"'
Autor:
Cindy Y. Ly, Jessica Pfannenstiel, Anil Pant, Zhilong Yang, Anthony R. Fehr, Maxim S. Rodzkin, David J. Davido
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT We utilized a high-throughput cell-based assay to screen several chemical libraries for inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora kinase inhibitors were identified that potently reduced gene
Externí odkaz:
https://doaj.org/article/7f189312271f454290d415a1f257e4c8
Autor:
Mirna Perusina Lanfranca, Jessica M. van Loben Sels, Cindy Y. Ly, Tristan R. Grams, Adit Dhummakupt, David C. Bloom, David J. Davido
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT Herpes simplex virus 1 (HSV-1) is a human pathogen capable of establishing lifelong latent infections that can reactivate under stress conditions. A viral immediate early protein that plays important roles in the HSV-1 lytic and latent infec
Externí odkaz:
https://doaj.org/article/c1e419a7965b431cae287de5ad6ff9d2
Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication
Publikováno v:
Viruses, Vol 14, Iss 5, p 869 (2022)
We previously isolated an HSV-1 mutant, KOS-NA, that contains two non-synonymous mutations in UL39. One of the mutations, resulting in an R950H amino acid substitution in ICP6, renders KOS-NA severely neuro-attenuated and significantly reduces HSV-1
Externí odkaz:
https://doaj.org/article/ba2e88aa9f304e5cbf395c2e83644188
Publikováno v:
Cells, Vol 3, Iss 4, Pp 1131-1158 (2014)
Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate. One such factor is the promyelocytic le
Externí odkaz:
https://doaj.org/article/b62e25954c8645a2b26a968c8bfcdd4a
Publikováno v:
Cells, Vol 3, Iss 2, Pp 438-454 (2014)
The herpes simplex virus type 1 (HSV-1) encoded E3 ubiquitin ligase, infected cell protein 0 (ICP0), is required for efficient lytic viral replication and regulates the switch between the lytic and latent states of HSV-1. As an E3 ubiquitin ligase, I
Externí odkaz:
https://doaj.org/article/12aeaea00516456d840136641f703c71
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2931
Volume 24
Issue 3
Pages: 2931
Herpes simplex virus 1 (HSV-1) enters sensory neurons with the potential for productive or latent infection. For either outcome, HSV-1 must curtail the intrinsic immune response, regulate viral gene expression, and remove host proteins that could res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e90b81f2ec233911b65f3d5a32e71d8
https://doi.org/10.3390/ijms24032931
https://doi.org/10.3390/ijms24032931
Publikováno v:
Antiviral Res
Herpes simplex virus 1 (HSV-1) is a ubiquitous virus that results in lifelong infections due to it’s ability to cycle between lytic replication and latency. As an obligate intracellular pathogen, HSV-1 exploits host cellular factors to replicate an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd790fcc0cb54ee07f04acb0be2e96a
https://europepmc.org/articles/PMC8686521/
https://europepmc.org/articles/PMC8686521/
Autor:
Benjamin Combs, Maria Korom, David J. Davido, Eleain M. Tu, Hong Wang, P. Jahnu Reddy, Steven Haenchen, Heba H. Mostafa, Lynda A. Morrison, Andreu Gazquez Casals
Publikováno v:
Journal of Virology. 92
We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in UL39, resulting in L393P and R950H amino acid substitutions in infected cell protein 6 (ICP6). Our published data studying KOS-NA path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9f558327861f656bdd0f2e28a14ed2
https://doi.org/10.1128/jvi.01036-18
https://doi.org/10.1128/jvi.01036-18
Autor:
Stuart J. Macdonald, David J. Davido, Steven Haenchen, Lynda A. Morrison, Thornton W. Thompson, Adam J. Konen, Joshua G. Hilliard, Heba H. Mostafa
In the process of generating herpes simplex virus 1 (HSV-1) mutations in the viral regulatory gene encoding infected cell protein 0 (ICP0), we isolated a viral mutant, termed KOS-NA, that was severely impaired for acute replication in the eyes and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2685679c9583b99eb64371d51f151fa7
https://europepmc.org/articles/PMC5972887/
https://europepmc.org/articles/PMC5972887/
Publikováno v:
Antiviral Research. 120:1-6
The herpes simplex virus type 1 (HSV-1) immediate-early phosphoprotein infected cell protein 0 (ICP0) is a potent transcriptional activator of viral genes and is required for efficient viral replication and reactivation from latency. However, it is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddf4141f9e326f0fad5d9e8b898e576
https://doi.org/10.1016/j.antiviral.2015.04.012
https://doi.org/10.1016/j.antiviral.2015.04.012