Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David J. Dale"'
Publikováno v:
Organic Process Research & Development. 13:1388-1394
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a24e3e57852bab60f570779ab44ae91
https://doi.org/10.1021/op900254g
https://doi.org/10.1021/op900254g
Autor:
Mike Hawksworth, Derek L. Tickner, Richard W. Barnhart, Ying Kang, Brian Moon, Stephen M. Shaw, Taber Geraldine Patricia, Paul Higginson, David J. Dale, Jerry D. Clark, Gerald A. Weisenburger, Donald J. Knoechel
Publikováno v:
Organic Process Research & Development. 11:1112-1125
The heat of reaction is an important parameter in the safe, successful scale-up of chemical processes. Reaction heat data is used to calculate the potential adiabatic temperature rise of the desire...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7e55b4b6c0025cc33fdccda53b3fed9
https://doi.org/10.1021/op700173h
https://doi.org/10.1021/op700173h
Autor:
David J. Dale
Publikováno v:
Organic Process Research & Development. 6:933-937
The requirement for a systematic approach to chemical reaction screening is described along with a comparison of results from some commercially available equipment. The limitations of using differential scanning calorimetry (DSC) as a screening tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c359710e39714f73304c9d739f89fee1
https://doi.org/10.1021/op025592f
https://doi.org/10.1021/op025592f
Autor:
Peter J. Dunn, Philip Charles Levett, Albert Shaw Wood, Farhat Hussain, John Draper, Gordon Ward, David J. Dale, Hughes Michael Leslie
Publikováno v:
Organic Process Research & Development. 6:767-772
A case history is outlined for the development of a scaleable route to the drug candidate UK-357,903. Despite the partial structural similarities to those of sildenafil (Viagra), the introduction of the central pyridine moiety within UK-357,903 had a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc24004198a915f68fa8fc297e896c75
https://doi.org/10.1021/op0200468
https://doi.org/10.1021/op0200468
Autor:
Mike Baker, Robert B. Hammond, Kevin J. Roberts, L Ford, D Merrifield, Duncan Roberts, Will M. L. Wood, Peter Erk, Latham William David Stuart, Raymond Oliver, Patricia Mougin, K Liang, David J. Dale, Xiaojun Lai, Graeme White, Zhiyi Cao, Nicolas Savelli, Derek Wilkinson, Alastair Thomas, H Groen
Publikováno v:
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 356:273-287
In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: • reactant supersaturation via ATR-FTIR spectros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d6a0755f7a2db4370f11462ca7cd01
https://doi.org/10.1080/10587250108023707
https://doi.org/10.1080/10587250108023707
Autor:
Patricia M. Searle, David J. Dale, Hughes Michael Leslie, Gordon Ward, Peter J. Dunn, Albert Shaw Wood, Philip Charles Levett, Andrew K. Pearce, Clare Golightly
Publikováno v:
Organic Process Research & Development. 4:17-22
This paper is a case history of the chemical development of sildenafil which covers various aspects of work in chemical development namely: route selection, scale-up issues, the development of an efficient synthesis with high throughput, process safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527f717c83a5fb487e313fcdade8451f
https://doi.org/10.1021/op9900683
https://doi.org/10.1021/op9900683
Autor:
David J. Dale
The requirement for a systematic approach to chemical reaction hazards that is aligned with the process development lifecycle for the pharmaceutical industry is described in this chapter. The discussion includes an overview of what are the major chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8c53b641a370ee58eff88a58ff370b
https://doi.org/10.1039/9781849733076-00160
https://doi.org/10.1039/9781849733076-00160
Autor:
Peter J. Dunn, Albert Shaw Wood, Gordon Ward, Clare Golightly, Hughes Michael Leslie, Andrew K. Pearce, David J. Dale, Patricia M. Searle, Philip Charles Levett
Publikováno v:
ChemInform. 31
This paper is a case history of the chemical development of sildenafil which covers various aspects of work in chemical development namely: route selection, scale-up issues, the development of an efficient synthesis with high throughput, process safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac6ee85550583d2af9de63e90ef063b
https://doi.org/10.1002/chin.200015242
https://doi.org/10.1002/chin.200015242
Autor:
Farhat Hussain, John C. Mitchell, David J. Dale, Robert Bright, Ying Kang, Martin J. Snowden, Peter J. Dunn, Clive Mason
Three catalysts were used to promote an imidazolide coupling. These catalysts were 2-hydroxypyridine (HOPy), endo-N-hydroxy-5-norbornene-2,3-dicarboximide (HONB) (both reported for the first time to catalyse this type of reaction), and 1-hydroxybenzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef9290597a83950cdb6c4746a6d7136
http://gala.gre.ac.uk/id/eprint/4153/1/(ITEM_4153)_ABSTRACT_IMAGE_op049874mn00001.jpg
http://gala.gre.ac.uk/id/eprint/4153/1/(ITEM_4153)_ABSTRACT_IMAGE_op049874mn00001.jpg
_ABSTRACT_IMAGE_op049874mn00001.jpg){kind=link}
Autor:
Gerald A. Weisenburger, Richard W. Barnhart, Jerry D. Clark, David J. Dale, Mike Hawksworth, Paul D. Higginson, Ying Kang, Donald J. Knoechel, Brian S. Moon, Stephen M. Shaw, Geraldine P. Taber, Derek L. Tickner
Publikováno v:
Organic Process Research & Development; Oct2007, Vol. 11 Issue 6, p1112-1125, 14p