Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David J. Cummins"'
Publikováno v:
ACS Medicinal Chemistry Letters
Biochemical assay interference is becoming increasingly recognized as a significant waste of resource in drug discovery, both in industry and academia. A seminal publication from Baell and Holloway raised the awareness of this issue, and they publish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4e0c4a53e53f16818111b29f4e548f
https://doi.org/10.1021/acsmedchemlett.8b00097
https://doi.org/10.1021/acsmedchemlett.8b00097
Autor:
Manuel Molina-Martin, Juan F. Espinosa, Patrick R. Griffin, David J. Cummins, Alfonso Espada, Devrishi Goswami, Howard B. Broughton, Ryan Edward Stites, Bruce D. Pascal, Michael J. Chalmers, Jeffrey Alan Dodge, Scott J. Novick
Publikováno v:
Analytical Chemistry. 88:6607-6614
Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) is an information-rich biophysical method for the characterization of protein dynamics. Successful applications of differential HDX-MS include the characterization of protein-ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4811489bad786b8766bf5b85c872c
https://doi.org/10.1021/acs.analchem.6b01650
https://doi.org/10.1021/acs.analchem.6b01650
Autor:
Michael A. Bell, David J. Cummins
Publikováno v:
Journal of Medicinal Chemistry. 59:6999-7010
In recent years there have been numerous papers on the topic of multiattribute optimization in pharmaceutical discovery chemistry, applied to compound prioritization. Many solutions proposed are static in nature; fixed functions are proposed for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec12f6f81a5590ff339c7f0bafbbe4c
https://doi.org/10.1021/acs.jmedchem.5b01338
https://doi.org/10.1021/acs.jmedchem.5b01338
Publikováno v:
Expert Review of Proteomics. 2:669-680
Sepsis is a multifactorial disease that provides unique challenges to the critical care physician. Diagnosis is hampered by the lack of a quantitative in vitro diagnostic test, instead, it relies on a series of clinical measures. The complex nature o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afb9a43dfb6b2ec7331a86df5f72d49
https://doi.org/10.1586/14789450.2.5.669
https://doi.org/10.1586/14789450.2.5.669
Publikováno v:
Science. 295:2264-2267
The deposition of amyloid-β (Aβ) peptides into amyloid plaques precedes the cognitive dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative of brain amyloid burden could be useful for identifying individuals at high risk for devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919705699a31a61b961f57f112e85d10
https://doi.org/10.1126/science.1067568
https://doi.org/10.1126/science.1067568
Publikováno v:
European Journal of Neuroscience. 14:474-482
It has been postulated that neuroinflammation plays a critical role in the pathogenesis of Alzheimer's disease (AD). To directly test whether an inflammatory stimulus can accelerate amyloid deposition in vivo, we chronically administered the bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89060c8d48a972a2139f7f96e968989f
https://doi.org/10.1046/j.0953-816x.2001.01666.x
https://doi.org/10.1046/j.0953-816x.2001.01666.x
Autor:
Cynthia DeLong, Michail A. Esterman, William H. Jordan, Sandy L. White, Kelly R. Bales, Steven M. Paul, Cindy E. Fishman, David J. Cummins, Jeffery C. Hanson
Publikováno v:
Journal of Neuroscience Methods. 108:145-152
Cerebral beta-amyloidosis is a central part of the neuropathology of Alzheimer's disease (AD). Quantitation of beta-amyloid plaques in the human AD brain, and in animal models of AD, is an important study endpoint in AD research. Methodologic approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37df4f1b0d50b0731399d6c3207c835
https://doi.org/10.1016/s0165-0270(01)00381-8
https://doi.org/10.1016/s0165-0270(01)00381-8
Publikováno v:
Journal of the American Statistical Association. 96:233-246
Numerous nonparametric regression methods exist that yield consistent estimators of function curves. Often, one is also interested in constructing confidence intervals for the unknown function. When a function estimate is based on a single global smo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08339b9deb24c7b110a565a0853db4eb
https://doi.org/10.1198/016214501750332811
https://doi.org/10.1198/016214501750332811
Autor:
David J. Cummins, Michal Vieth
Publikováno v:
Journal of Medicinal Chemistry. 43:3020-3032
DoMCoSAR is a novel approach for statistically determining the docking mode that is consistent with a structure-activity relationship. The approach establishes the binding mode for the compounds in a chemical series with the assumption that all molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571bbcd4bc5d5f50db4db9d4129700a9
https://doi.org/10.1021/jm990609e
https://doi.org/10.1021/jm990609e
Autor:
Kelly R. Bales, Steven M. Paul, Josep Saura, Valérie Petegnief, Bernardino Ghetti, Richard C. Dodel, Yansheng Du, Tatyana Verina, Pedro Piccardo, David J. Cummins, Cindy E. Fishman, Cynthia DeLong
Publikováno v:
Proceedings of the National Academy of Sciences. 96:15233-15238
We quantified the amount of amyloid β-peptide (Aβ) immunoreactivity as well as amyloid deposits in a large cohort of transgenic mice overexpressing the V717F human amyloid precursor protein ( APP V717F+/− TG mice) with no, one, or two mouse apoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96c1d0364bcaad243fc55efa204f8ed
https://doi.org/10.1073/pnas.96.26.15233
https://doi.org/10.1073/pnas.96.26.15233