Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David J. Crossman"'
Autor:
Yufeng Hou, Jizhong Bai, Xin Shen, Oscar de Langen, Amy Li, Sean Lal, Cristobal G. dos Remedios, David Baddeley, Peter N. Ruygrok, Christian Soeller, David J. Crossman
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The disrupted organisation of the ryanodine receptors (RyR) and junctophilin (JPH) is thought to underpin the transverse tubule (t-tubule) remodelling in a failing heart. Here, we assessed the nanoscale organisation of these two key proteins in the f
Externí odkaz:
https://doaj.org/article/b2bbfa1206e548a38c1020f6a2d5211e
Autor:
Izzy Jayasinghe, Alexander H. Clowsley, Oscar de Langen, Sonali S. Sali, David J. Crossman, Christian Soeller
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Remodelling of the membranes and protein clustering patterns during the pathogenesis of cardiomyopathies has renewed the interest in spatial visualisation of these structures in cardiomyocytes. Coincidental emergence of single molecule (super-resolut
Externí odkaz:
https://doaj.org/article/9ec4d5a1c6c044c5b36200a68ee41172
Autor:
Claire L. Curl, Vennetia R. Danes, James R. Bell, Antonia J. A. Raaijmakers, Wendy T. K. Ip, Chanchal Chandramouli, Tristan W. Harding, Enzo R. Porrello, Jeffrey R. Erickson, Fadi J. Charchar, Andrew R. Kompa, Amanda J. Edgley, David J. Crossman, Christian Soeller, Kimberley M. Mellor, Jonathan M. Kalman, Stephen B. Harrap, Lea M. D. Delbridge
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 11 (2018)
BackgroundAmong the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need—and the l
Externí odkaz:
https://doaj.org/article/1d494628ead14a7dbee011a799b45a35
Autor:
Isuru D. Jayasinghe, Alexander H. Clowsley, Michelle Munro, Yufeng Hou, David J. Crossman, Christian Soeller
Publikováno v:
European Journal of Translational Myology, Vol 25, Iss 1, Pp 15-26 (2014)
The t-tubular system plays a central role in the synchronisation of calcium signalling and excitation-contraction coupling in most striated muscle cells. Light microscopy has been used for imaging t-tubules for well over 100 years and together with e
Externí odkaz:
https://doaj.org/article/e43a056b2475454bab1a8a71471ea98a
Publikováno v:
PLoS ONE, Vol 6, Iss 4 (2011)
Externí odkaz:
https://doaj.org/article/232fb02bcb6340a3b99398230619d8c5
Right-sided heart failure is also associated with transverse tubule remodeling in the left ventricle
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H940-H947
In this work, we demonstrate that t-tubule remodeling occurs in the atrophied left ventricle as well as the overloaded right ventricle after right-side heart failure. Moreover, we identify that t-tubule remodeling in both ventricles is linked to sarc
Publikováno v:
Biophys Rev
A women in science symposium was held at the combined 20th International Union for Pure and Applied Biophysics (IUPAB) Congress, 45th Annual Brazilian Biophysical Society (SBBf) Meeting and 50th Annual Brazilian Society for Biochemistry and Molecular
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48:137-146
Acute cellular rejection after cardiac transplantation surgery is routinely monitored by pathological assessment of haematoxylin and eosin (H&E) histology of endomyocardial biopsies (EMB). Unfortunately, there is considerable variation in the diagnos
Publikováno v:
Biophys Rev
Myocardial fibrosis is recognized as a key pathological process in the development of cardiac disease and a target for future therapeutics. Despite this recognition, the assessment of fibrosis is not a part of routine clinical practice. This is prima
Publikováno v:
Biophys Rev
Myocardial fibrosis is recognized as a key pathological process in the development of cardiac disease and a target for future therapeutics. Despite this recognition, the assessment of fibrosis is not a part of routine clinical practice. This is prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb444b481394b7573e2547d534ce2c95
https://europepmc.org/articles/PMC9250562/
https://europepmc.org/articles/PMC9250562/