Zobrazeno 1 - 10
of 113
pro vyhledávání: '"David J. Cardin"'
Autor:
Kane T. McQuaid, Shuntaro Takahashi, Lena Baumgaertner, David J. Cardin, Neil G. Paterson, James P. Hall, Naoki Sugimoto, Christine J. Cardin
Publikováno v:
Journal of the American Chemical Society. 144:5956-5964
The DNA G-quadruplex is known for forming a range of topologies and for the observed lability of the assembly, con-sistent with its transient formation in live cells. The stabilisation of a particular topology by a small molecule is of great importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf4a5b8e310a59cd1b877bd0b5a8a83
https://doi.org/10.1021/jacs.2c00178
https://doi.org/10.1021/jacs.2c00178
Autor:
Christine J. Cardin, Holly Abell, Thomas Sorensen, Kane McQuaid, John A. Brazier, James P. Hall, Graeme Winter, Sarah P. Gurung, David R. Allan, David J. Cardin
Publikováno v:
Angewandte Chemie International Edition. 58:9881-9885
Using X-ray crystallography, we show an enantiospecificity in DNA G-quadruplex binding, using the complexes Λ/∆-[Ru(TAP)2(dppz-11-CN)]2+ (TAP=1,4,5,8-tetraazaphenanthrene) containing the dppz (dipyridophenazine) ligand, paralleling the specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40157d90f7531fa3b9b0da8d9ca3da80
https://doi.org/10.1002/anie.201814502
https://doi.org/10.1002/anie.201814502
Publikováno v:
Chemical Communications. 55:9116-9119
Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c830e323c5aa25ebb38aeb6c3d1029c
https://doi.org/10.1039/c9cc04316k
https://doi.org/10.1039/c9cc04316k
Publikováno v:
Coordination Chemistry Reviews. 335:103-149
Transition metal complexes with π-allylic ligands remain an attractive topic in organometallic chemistry, given the numerous reports of a wide variety of synthetic routes, dynamic behaviour and reactivity, structural (including isomerism), spectrosc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f4e5b4ea2793497fa6382625d73287
https://doi.org/10.1016/j.ccr.2016.12.018
https://doi.org/10.1016/j.ccr.2016.12.018
Publikováno v:
Chemical communications (Cambridge, England). 55(62)
Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::781000913138db1c0313de10379bf480
https://pubmed.ncbi.nlm.nih.gov/31298665
https://pubmed.ncbi.nlm.nih.gov/31298665
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(59)
The new complexes [Ru(TAP)2 (11-CN-dppz)]2+ , [Ru(TAP)2 (11-Br-dppz)]2+ and [Ru(TAP)2 (11,12-diCN-dppz)]2+ are reported. The addition of nitrile substituents to the dppz ligand of the DNA photo-oxidising complex [Ru(TAP)2 (dppz)]2+ promote π-stackin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812ef081008393405756e29b04d2960a
https://pubmed.ncbi.nlm.nih.gov/30063271
https://pubmed.ncbi.nlm.nih.gov/30063271
Autor:
Christine J. Cardin, Fergus E. Poynton, Igor V. Sazanovich, Susan J. Quinn, David J. Cardin, Páraic M. Keane, Sarah P. Gurung, James P. Hall, John M. Kelly, Michael Towrie, John A. Brazier, Thorfinnur Gunnlaugsson, Graeme Winter
Publikováno v:
Nature Chemistry. 7:961-967
To understand the molecular origins of diseases caused by ultraviolet and visible light, and also to develop photodynamic therapy, it is important to resolve the mechanism of photoinduced DNA damage. Damage to DNA bound to a photosensitizer molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c87f6f09bc5d449db9a922cab3612a
https://doi.org/10.1038/nchem.2369
https://doi.org/10.1038/nchem.2369
Publikováno v:
Organometallics. 34:2481-2486
Polypyridyl ruthenium complexes have been intensively studied and possess photophysical properties that are both interesting and useful. They can act as probes for DNA, with a substantial enhancement in emission when bound, and can induce DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::504f2a01df31766d6f8134d494aa1983
https://doi.org/10.1021/om501208x
https://doi.org/10.1021/om501208x
Autor:
Cora Alberti, J. Sanchez-Weatherby, Kyra O’Sullivan, John A. Brazier, Christine J. Cardin, Graeme Winter, David J. Cardin, Caroline Hurtado Quimper, John M. Kelly, James P. Hall, Thomas Sorensen
Publikováno v:
Journal of the American Chemical Society. 136:17505-17512
Hydration-dependent DNA deformation has been known since Rosalind Franklin recognized that the relative humidity of the sample had to be maintained to observe a single conformation in DNA fiber diffraction. We now report for the first time the crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b054d0275212d6d5ede079941195cc
https://doi.org/10.1021/ja508745x
https://doi.org/10.1021/ja508745x
Autor:
John M. Kelly, Graeme Winter, Daniel Cook, Christine J. Cardin, Sara Ruiz Morte, David J. Cardin, Patrick McIntyre, Hanna Beer, John A. Brazier, Katrin Buchner, James P. Hall
Publikováno v:
Journal of the American Chemical Society. 135:12652-12659
We report an atomic resolution X-ray crystal structure containing both enantiomers of rac-[Ru(phen)2dppz](2+) with the d(ATGCAT)2 DNA duplex (phen = phenanthroline; dppz = dipyridophenazine). The first example of any enantiomeric pair crystallized wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd08dd362af147a5a7c0591ec712620
https://doi.org/10.1021/ja403590e
https://doi.org/10.1021/ja403590e