Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David J. C. Alders"'
Publikováno v:
American Journal of Physiology. Heart and Circulatory Physiology, 309(10), H1708-H1719. American Physiological Society
Alders, D J, Groeneveld, A B J, Binsl, T W & van Beek, J H G M 2015, ' Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 309, no. 10, pp. H1708-H1719 . https://doi.org/10.1152/ajpheart.00657.2014
AJP-Heart and Circulatory Physiology, 309(10), H1708-H1719
American Journal of Physiology-Heart and Circulatory Physiology, 309(10), H1708-H1719. American Physiological Society
Alders, D J, Groeneveld, A B J, Binsl, T W & van Beek, J H G M 2015, ' Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 309, no. 10, pp. H1708-H1719 . https://doi.org/10.1152/ajpheart.00657.2014
AJP-Heart and Circulatory Physiology, 309(10), H1708-H1719
American Journal of Physiology-Heart and Circulatory Physiology, 309(10), H1708-H1719. American Physiological Society
In normal hearts, myocardial perfusion is fairly well matched to regional metabolic demand, although both are distributed heterogeneously. Nonuniform regional metabolic vulnerability during coronary stenosis would help to explain nonuniform necrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99632127c1a41f70cfe88df99a97ea6
https://research.vu.nl/en/publications/9b2de149-5434-4c2b-9cbd-be1492ad0ec8
https://research.vu.nl/en/publications/9b2de149-5434-4c2b-9cbd-be1492ad0ec8
Autor:
Thomas W. Binsl, A. B. Johan Groeneveld, Johannes H. G. M. van Beek, Frans J. J. de Kanter, David J. C. Alders
Publikováno v:
American Journal of Physiology. Heart and Circulatory Physiology, 300(4), H1459-H1466. American Physiological Society
Alders, D J C, Groeneveld, A B J, Binsl, T W, de Kanter, F J & van Beek, J H G M 2011, ' Endotoxemia decreases matching of regional blood flow and O(2) delivery to O(2) uptake in the porcine left ventricle ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 300, no. 4, pp. H1459-H1466 . https://doi.org/10.1152/ajpheart.00287.2010
Alders, D J C, Groeneveld, A B J, Binsl, T W, de Kanter, F J & van Beek, J H G M 2011, ' Endotoxemia decreases matching of regional blood flow and O(2) delivery to O(2) uptake in the porcine left ventricle ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 300, no. 4, pp. H1459-H1466 . https://doi.org/10.1152/ajpheart.00287.2010
Heterogeneity of regional coronary blood flow is caused in part by heterogeneity in O2 demand in the normal heart. We investigated whether myocardial O2 supply/demand mismatching is associated with the myocardial depression of sepsis. Regional blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf44ce5d827613db798892be1d76a30
https://hdl.handle.net/1871.1/c9e4c155-e906-40d1-91cf-4859bc3e6ad3
https://hdl.handle.net/1871.1/c9e4c155-e906-40d1-91cf-4859bc3e6ad3
Autor:
Richard Cornelussen, Mark I. M. Noble, Johannes H. G. M. van Beek, Frits W. Prinzen, Angela J. Drake-Holland, Frans J. J. de Kanter, Patricia A. C. Specht, David J. C. Alders
Publikováno v:
Experimental Physiology. 92:541-548
Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism–perfusion relation is influenced by sympathetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d28e4ba141940fd61f16d8bddc5dd43
https://doi.org/10.1113/expphysiol.2006.036228
https://doi.org/10.1113/expphysiol.2006.036228
Publikováno v:
Basic Research in Cardiology. 96:575-581
The literature is reviewed on methods to assess heterogeneity of blood flow, substrate uptake and oxidative end energy metabolism in the normal heart, and their interrelations. Even though the factors controlling matching on the regional level remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8fa9b4006208a93f099906671fe471
https://doi.org/10.1007/s003950170009
https://doi.org/10.1007/s003950170009
Autor:
J. Bussemaker, F.J.J. de Kanter, Richard B. King, H. G. J. Van Mil, J.H.G.M. van Beek, David J. C. Alders
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 277:H1630-H1640
Measurement of local myocardial O2consumption (V˙o2) has been problematic but is needed to investigate the heterogeneity of aerobic metabolism. The goal of the present investigation was to develop a method to measure local V˙o2using small frozen my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e582e794af7e724501173c22de0837e
https://doi.org/10.1152/ajpheart.1999.277.4.h1630
https://doi.org/10.1152/ajpheart.1999.277.4.h1630
Autor:
Jaap Heringa, Johannes H. G. M. van Beek, Thomas W. Binsl, David J. C. Alders, A. B. Johan Groeneveld
Publikováno v:
Bioinformatics, 26(5), 653-660. Oxford University Press
Binsl, T W, Alders, D J C, Heringa, J, Groeneveld, A B J & van Beek, J H G M 2010, ' Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy. ', Bioinformatics, vol. 26, no. 5, pp. 653-660 . https://doi.org/10.1093/bioinformatics/btq018
Binsl, T W, Alders, D J C, Heringa, J, Groeneveld, A B J & van Beek, J H G M 2010, ' Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy. ', Bioinformatics, vol. 26, no. 5, pp. 653-660 . https://doi.org/10.1093/bioinformatics/btq018
Motivation: Quantitative determination of metabolic fluxes in single tissue biopsies is difficult. We report a novel analysis approach and software package for in vivo flux quantification using stable isotope labeling. Results: We developed a protoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1de7e14b90bd850297981b98e544760
https://pubmed.ncbi.nlm.nih.gov/20097912
https://pubmed.ncbi.nlm.nih.gov/20097912
Autor:
David J C, Alders, Richard N, Cornelussen, Frits W, Prinzen, Patricia A C, Specht, Mark I M, Noble, Angela J, Drake-Holland, Frans J J, de Kanter, Johannes H G M, van Beek
Publikováno v:
Experimental physiology. 92(3)
Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced by sympathetic de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16e2f45dff8fee208085c55c18898ab5
https://pubmed.ncbi.nlm.nih.gov/17303649
https://pubmed.ncbi.nlm.nih.gov/17303649
Autor:
A. B. Johan Groeneveld, Joli Bussemaker, Johannes H. G. M. van Beek, Harald G. J. van Mil, Antonie A. van Lambalgen, Glenn Harrison, David J. C. Alders, Frans J. J. de Kanter
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461371373
Perfusion of the heart muscle is very heterogeneous, even in the healthy heart (Bassingthwaighte et al., 1989). The most important aspect is not the heterogeneity of perfusion or metabolism per se, but whether the blood delivers the oxygen necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bfccd2ed20de1802c87090b34975655
https://doi.org/10.1007/978-1-4615-4717-4_33
https://doi.org/10.1007/978-1-4615-4717-4_33
Autor:
David J. C. Alders, Thomas W. Binsl, Hannes Hettling, A. B. Johan Groeneveld, Jaap Heringa, Johannes H. G. M. van Beek
Publikováno v:
BMC Systems Biology
Hettling, H, Alders, D J, Heringa, J, Binsl, T W, Groeneveld, A B J & van Beek, J H G M 2013, ' Computational estimation of tricarboxylic acid cycle fluxes using noisy NMR data from cardiac biopsies ', BMC Systems Biology, vol. 7, pp. 82 . https://doi.org/10.1186/1752-0509-7-82
BMC Systems Biology, 7. BioMed Central
BMC Systems Biology, 7. BioMed Central Ltd.
Hettling, H, Alders, D J, Heringa, J, Binsl, T W, Groeneveld, A B J & van Beek, J H G M 2013, ' Computational estimation of tricarboxylic acid cycle fluxes using noisy NMR data from cardiac biopsies ', BMC Systems Biology, vol. 7, pp. 82 . https://doi.org/10.1186/1752-0509-7-82
BMC Systems Biology, 7. BioMed Central
BMC Systems Biology, 7. BioMed Central Ltd.
Background The aerobic energy metabolism of cardiac muscle cells is of major importance for the contractile function of the heart. Because energy metabolism is very heterogeneously distributed in heart tissue, especially during coronary disease, a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd21138b58400ade94ca3e628332770
https://doi.org/10.1186/1752-0509-7-82
https://doi.org/10.1186/1752-0509-7-82
Publikováno v:
Mitochondrion. 10:231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b1976a17280b12f14d90a4cde829ee
https://doi.org/10.1016/j.mito.2009.12.104
https://doi.org/10.1016/j.mito.2009.12.104