Zobrazeno 1 - 10
of 144
pro vyhledávání: '"David J. Buttle"'
Autor:
Victor S. Njom, Tim Winks, Oumu Diallo, Ann Lowe, Jerzy Behnke, Mark J. Dickman, Ian Duce, Iain Johnstone, David J. Buttle
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Plant-derived cysteine proteinases of the papain family (CPs) attack nematodes by digesting the cuticle, leading to rupture and death of the worm. The nematode cuticle is composed of collagens and cuticlins, but the specific molec
Externí odkaz:
https://doaj.org/article/1b361152734241d987af742259d09dbe
Autor:
Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides, Colin Farquharson
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether dis
Externí odkaz:
https://doaj.org/article/d38e50db61e14135b3a5070ed6bef26f
Autor:
Timothy J. Mead, Yaoyao Du, Courtney M. Nelson, Ndeye-Aicha Gueye, Judith Drazba, Carolyn M. Dancevic, Mireille Vankemmelbeke, David J. Buttle, Suneel S. Apte
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 485-498 (2018)
Summary: Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus. Here, we identify proteolytic turnover of the anti-
Externí odkaz:
https://doaj.org/article/608e794dc4a14877a77c304ed6fb224e
Autor:
Jerzy M. Behnke, Iain L. Johnstone, Oumu Diallo, Tim Winks, Ann Lowe, Ian R. Duce, Victor S. Njom, David J. Buttle, Mark J. Dickman
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-11 (2021)
Parasites & Vectors
Parasites & Vectors
Background Plant-derived cysteine proteinases of the papain family (CPs) attack nematodes by digesting the cuticle, leading to rupture and death of the worm. The nematode cuticle is composed of collagens and cuticlins, but the specific molecular targ
Publikováno v:
Heliyon, Vol 7, Iss 10, Pp e08125-(2021)
Heliyon
Heliyon
Plant derived cysteine proteinases (CPs) have long been known to possess anthelmintic properties but have attracted renewed attention recently because of the acute need to discover novel methods for controlling helminth infections as a result of incr
Autor:
Suneel S. Apte, Yaoyao Du, Carolyn M. Dancevic, Courtney M. Nelson, David J. Buttle, Timothy J. Mead, Judith A. Drazba, Mireille Vankemmelbeke, Ndeye Aicha Gueye
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 485-498 (2018)
Cell reports
Cell reports
SUMMARY Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus. Here, we identify proteolytic turnover of the anti-a
Autor:
James W.F. Catto, Massimiliano Mellone, Daniel W. Lambert, Ricardo D. Coletta, Stephen S. Prime, Priyanka Prajapati, Gareth J. Thomas, Emma E. Hinsley, E. Ken Parkinson, David J. Buttle, Siti A Abidin, Genevieve E Melling, Stuart Hunt, Sarah E Flannery, Ian C. Paterson, Hannah Clemmens
Publikováno v:
Carcinogenesis. 39:798-807
The dissemination of cancer cells to local and distant sites depends on a complex and poorly understood interplay between malignant cells and the cellular and non-cellular components surrounding them, collectively termed the tumour microenvironment.
Autor:
Ekele Ikpegbu, Anish K. Amin, Behzad Javaheri, Scott Dillon, Andrew A. Pitsillides, Anna E. Törnqvist, Katherine Staines, Dylan N. Clements, David J. Buttle, Colin Farquharson
Publikováno v:
BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-11 (2019)
Staines, K, Ikpegbu, E, Tornqvist, A, Dillon, S, Javaheri, B, Amin, A, Clements, D, Buttle, D, Pitsillides, A A & Farquharson, C 2019, ' Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis ', BMC Musculoskeletal Disorders, vol. 20, 344 . https://doi.org/10.1186/s12891-019-2731-9
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-11 (2019)
Staines, K, Ikpegbu, E, Tornqvist, A, Dillon, S, Javaheri, B, Amin, A, Clements, D, Buttle, D, Pitsillides, A A & Farquharson, C 2019, ' Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis ', BMC Musculoskeletal Disorders, vol. 20, 344 . https://doi.org/10.1186/s12891-019-2731-9
Background Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption t
Autor:
Katherine Staines, Andrew A. Pitsillides, Louise A. Stephen, Robert Fleming, Scott Dillon, Mark Hopkinson, David J. Buttle, Colin Farquharson, Antonia Sophocleous
Publikováno v:
Bioscience Reports
Staines, K A, Hopkinson, M, Dillon, S, Stephen, L A, Fleming, R, Sophocleous, A, Buttle, D J, Pitsillides, A A & Farquharson, C 2020, ' Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity ', Bioscience reports . https://doi.org/10.1042/BSR20190329
Staines, K A, Hopkinson, M, Dillon, S, Stephen, L A, Fleming, R, Sophocleous, A, Buttle, D J, Pitsillides, A A & Farquharson, C 2020, ' Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity ', Bioscience reports . https://doi.org/10.1042/BSR20190329
E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modelling/remodelling, through the production of receptor activator of nuclear factor κ B (RANK)-liga
Publikováno v:
Parasitology Research. 114:2535-2541
The development of plant-derived cysteine proteinases, such as those in papaya latex, as novel anthelmintics requires that the variables affecting efficacy be fully evaluated. Here, we conducted two experiments, the first to test for any effect of ho