Zobrazeno 1 - 10
of 189
pro vyhledávání: '"David J. Brayden"'
Autor:
Shane Forde, Giulianna Vozza, David J. Brayden, Hugh J. Byrne, Jesus M. Frías, Sinéad M. Ryan
Publikováno v:
Molecules, Vol 28, Iss 7, p 2941 (2023)
Selenium methionine (SeMet) is an essential micronutrient required for normal body function and is associated with additional health benefits. However, oral administration of SeMet can be challenging due to its purported narrow therapeutic index, low
Externí odkaz:
https://doaj.org/article/f6d4c3582f924829b05ed9524b38b5be
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112275- (2021)
Background: Food proteins are a source of hydrolysates with potentially useful biological attributes. Bioactive peptides from food-derived proteins are released from hydrolysates using exogenous industrial processes or endogenous intestinal enzymes.
Externí odkaz:
https://doaj.org/article/98c93f7df63b4a68a82e6ee9633a2460
Autor:
Sadaf Ejaz, Bridget Hogg, Delyan R. Hristov, David J. Brayden, Muhammad Imran, Sourav Bhattacharjee
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 830 (2022)
Crosslinked chitosan nanocarriers (140–160 nm) entrapping coumarin-6 (λex/em = 455/508 nm) with or without surface mannosylation were synthesized and assessed for cytotoxicity, adherence and cellular uptake in Caco-2 cells, flux across Caco-2 mono
Externí odkaz:
https://doaj.org/article/4e48d9fb10b34c6ebe4f173173ae579c
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1001 (2021)
The oral route of administration is by far the most convenient route, especially in the treatment of chronic conditions. However, many therapeutics present formulation difficulties which make them unsuitable for oral delivery. Recently, we synthesize
Externí odkaz:
https://doaj.org/article/648b800f325e41b3a0d88915270bbbe8
Autor:
Joanne Heade, Fiona McCartney, Miguel Chenlo, Olga Moreno Marro, Maja Severic, Robert Kent, Sinead B. Bleiel, Clara V. Alvarez, Brendan T. Griffin, David J. Brayden
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 656 (2021)
For many diabetics, daily, lifelong insulin injections are required to effectively manage blood glucose levels and the complications associated with the disease. This can be a burden and reduces patient quality of life. Our goal was to develop a more
Externí odkaz:
https://doaj.org/article/c01c94d1f0874249885cdebbad75c0fe
Autor:
Svenja Sladek, Fiona McCartney, Mena Eskander, David J. Dunne, Maria Jose Santos-Martinez, Federico Benetti, Lidia Tajber, David J. Brayden
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 259 (2020)
The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum mass mixing ratio of 5:1 (MR
Externí odkaz:
https://doaj.org/article/e27250b2b3294940bf24a17bb1d56209
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 565 (2019)
Oral delivery of macromolecules requires permeation enhancers (PEs) adaptable to formulation. Sucrose laurate (SL) (D1216), a food grade surfactant, was assessed in Caco-2 monolayers, isolated rat intestinal tissue mucosae, and rat intestinal instill
Externí odkaz:
https://doaj.org/article/132990aea7f840a6970bbc1b67b6a18a
Publikováno v:
Pharmaceutics, Vol 11, Iss 2, p 78 (2019)
Salcaprozate sodium (SNAC) and sodium caprate (C10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied fo
Externí odkaz:
https://doaj.org/article/61d28a5973274b619d400f667a20c77e
Publikováno v:
Pharmaceutics, Vol 11, Iss 1, p 41 (2019)
The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial ba
Externí odkaz:
https://doaj.org/article/8c314de793fd4baa9eff52430ae2e3e0
Autor:
David J, Brayden
Publikováno v:
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 36(6)
Oral administration of macromolecules aimed at systemic delivery has been at the forefront of pharmaceutical research for over 50 years. Yet, in terms of clinical translation for systemic delivery, output is limited to five US Food and Drug Administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8730d36b7005c15e907fc63901e0e977
https://pubmed.ncbi.nlm.nih.gov/36282433
https://pubmed.ncbi.nlm.nih.gov/36282433