Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David J. Boocock"'
Autor:
Hannah L. Morgan, Nader Eid, Nadine Holmes, Sonal Henson, Victoria Wright, Clare Coveney, Catherine Winder, Donna M. O’Neil, Warwick B. Dunn, David J. Boocock, Adam J. Watkins
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-25 (2024)
Abstract Background The importance of parental diet in relation to eventual offspring health is increasing in prominence due to the increased frequency of parents of reproductive age consuming poor diets. Whilst maternal health and offspring outcome
Externí odkaz:
https://doaj.org/article/e1295ee3491140b3827e61c34312c530
Autor:
Arnold Tan, Awais Z. Younis, Alexander Evans, Jade V. Creighton, Clare Coveny, David J. Boocock, Craig Sale, Gareth G. Lavery, Amanda S. Coutts, Craig L. Doig
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract The ADP-ribosyltransferase, PARP1 enzymatically generates and applies the post-translational modification, ADP-Ribose (ADPR). PARP1 roles in genome maintenance are well described, but recent work highlights roles in many fundamental processe
Externí odkaz:
https://doaj.org/article/53b6b599c8154c79ab5165547b13a0c9
Autor:
Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia, Tarik Regad, Vincenzo Desiderio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background The long non-coding RNA (lncRNA), MALAT1, plays a key role in the development of different cancers, and its expression is associated with worse prognosis in patients. However, its mechanism of action and its regulation are not wel
Externí odkaz:
https://doaj.org/article/6775aa52ba8e4162a369ebbfb370a0a7
Autor:
Chiara Suanno, Elisa Tonoli, Enzo Fornari, Maria P. Savoca, Iris Aloisi, Luigi Parrotta, Claudia Faleri, Giampiero Cai, Clare Coveney, David J. Boocock, Elisabetta A. M. Verderio, Stefano Del Duca
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
IntroductionIn the last decade, it has been discovered that allergen-bearing extracellular nanovesicles, termed “pollensomes”, are released by pollen during germination. These extracellular vesicles (EVs) may play an important role in pollen-pist
Externí odkaz:
https://doaj.org/article/71e3d1997a0a435ab8a200e123d6d12d
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Exercise is a non-pharmacological intervention that can enhance bone regeneration and improve the management of bone conditions like osteoporosis or metastatic bone cancer. Therefore, it is gaining increasing importance in an emerging area o
Externí odkaz:
https://doaj.org/article/228cbdb7811546228228ea7a661c635c
Autor:
Bernadette Jeremiasse, Csaba Matta, Christopher R. Fellows, David J. Boocock, Julia R. Smith, Susan Liddell, Floris Lafeber, Willem E. van Spil, Ali Mobasheri
Publikováno v:
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degenerative changes and lo
Externí odkaz:
https://doaj.org/article/2d2c8e41fc57415f81b9fddbca946203
Autor:
Shaymaa IK. Al-Juboori, Jayakumar Vadakekolathu, Sarra Idri, Sarah Wagner, Dimitrios Zafeiris, Joshua RD. Pearson, Rukaia Almshayakhchi, Michele Caraglia, Vincenzo Desiderio, Amanda K. Miles, David J. Boocock, Graham R. Ball, Tarik Regad
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Metformin, a biguanide, is one of the most commonly prescribed treatments for type 2 diabetes and has recently been recommended as a potential drug candidate for advanced cancer therapy. Although Metformin has antiproliferative an
Externí odkaz:
https://doaj.org/article/1cd2486fd7f940c288cbd8bd63057da2
Autor:
Aslihan Ugun-Klusek, Theodosis S. Theodosi, Julia C. Fitzgerald, Florence Burté, Christoph Ufer, David J. Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E. Ellen Billett
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 167-181 (2019)
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive
Externí odkaz:
https://doaj.org/article/6433d8e6f4db46e580b30b0875bd1505
Autor:
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28–32°C). In these conditions, BAT is chronically hyperactive and, unlike human residen
Externí odkaz:
https://doaj.org/article/6ecbfa563278496fa036c1b3b4533ce3
Autor:
Micha M. M. Wilhelmus, Elisa Tonoli, Clare Coveney, David J. Boocock, Cornelis A. M. Jongenelen, John J. P. Brevé, Elisabetta A. M. Verderio, Benjamin Drukarch
Publikováno v:
Cells, Vol 11, Iss 3, p 389 (2022)
Amyloid-beta (Aβ) deposition in the brain is closely linked with the development of Alzheimer’s disease (AD). Unfortunately, therapies specifically targeting Aβ deposition have failed to reach their primary clinical endpoints, emphasizing the nee
Externí odkaz:
https://doaj.org/article/db50928aa4074b2abd325527228f1f9a