Zobrazeno 1 - 10
of 46
pro vyhledávání: '"David J. Abraham"'
Autor:
Marvin L. Frommer, Benjamin J. Langridge, Alexandra Beedie, Sara Jasionowska, Laura Awad, Christopher P. Denton, David J. Abraham, Jeries Abu-Hanna, Peter E. M. Butler
Publikováno v:
Cells, Vol 13, Iss 8, p 693 (2024)
Autologous fat transfers show promise in treating fibrotic skin diseases, reversing scarring and stiffness, and improving quality of life. Adipose-derived stem cells (ADSCs) within these grafts are believed to be crucial for this effect, particularly
Externí odkaz:
https://doaj.org/article/1f823a50defa40f5a8d34a31ab7e1af6
Autor:
Claire F. Beesley, Nina R. Goldman, Taher E. Taher, Christopher P. Denton, David J. Abraham, Rizgar A. Mageed, Voon H. Ong
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Systemic sclerosis (SSc) is a complex, immune-mediated rheumatic disease characterised by excessive extracellular matrix deposition in the skin and internal organs. B cell infiltration into lesional sites such as the alveolar interstitium and small b
Externí odkaz:
https://doaj.org/article/c03e3cb5b4e74408a4563c6c8163b069
Single-Cell Analysis of ADSC Interactions with Fibroblasts and Endothelial Cells in Scleroderma Skin
Autor:
Marvin L. Frommer, Benjamin J. Langridge, Laura Awad, Sara Jasionowska, Christopher P. Denton, David J. Abraham, Jeries Abu-Hanna, Peter E. M. Butler
Publikováno v:
Cells, Vol 12, Iss 13, p 1784 (2023)
Adipose-derived stem cells (ADSCs) as part of autologous fat grafting have anti-fibrotic and anti-inflammatory effects, but the exact mechanisms of action remain unknown. By simulating the interaction of ADSCs with fibroblasts and endothelial cells (
Externí odkaz:
https://doaj.org/article/770c9e5305ea4aa4bbcbb43d3d848a1c
Autor:
Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong, Christopher P. Denton
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have examined peroxisome
Externí odkaz:
https://doaj.org/article/29917a595917451aa674f32d4bacb9c8
Autor:
Emma C. Derrett-Smith, Viktor Martyanov, Cecilia B. Chighizola, Pia Moinzadeh, Corrado Campochiaro, Korsa Khan, Tammara A. Wood, Pier Luigi Meroni, David J. Abraham, Voon H. Ong, Robert Lafyatis, Michael L. Whitfield, Christopher P. Denton
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background Systemic sclerosis (SSc; scleroderma) is an uncommon autoimmune rheumatic disease characterised by autoimmunity, vasculopathy and fibrosis. Gene expression profiling distinguishes scleroderma from normal skin, and can detect diffe
Externí odkaz:
https://doaj.org/article/1e0cff8975e948cd8e58bbe0767ba842
Autor:
Daniela Gentile, Pietro E. Lazzerini, Alessandra Gamberucci, Mariarita Natale, Enrico Selvi, Francesca Vanni, Alessandra Alì, Paolo Taddeucci, Silvia Del-Ry, Manuela Cabiati, Veronica Della-Latta, David J. Abraham, Maria A. Morales, Rosella Fulceri, Franco Laghi-Pasini, Pier L. Capecchi
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Objectives: Systemic sclerosis (SSc) is a connective tissue disorder presenting fibrosis of the skin and internal organs, for which no effective treatments are currently available. Increasing evidence indicates that the P2X7 receptor (P2X7R), a nucle
Externí odkaz:
https://doaj.org/article/5b16d5004cd94d4389366910e179d482
Publikováno v:
Cardiology Research and Practice, Vol 2012 (2012)
Systemic sclerosis (scleroderma: SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ulti
Externí odkaz:
https://doaj.org/article/110002dd6fa945809a4dfa1175279a22
Autor:
Dhiraj Joshi, Janice Tsui, Rebekah Yu, Xu Shiwen, Sadasivam Selvakumar, David J. Abraham, Daryll M. Baker
Publikováno v:
Cardiology Research and Practice, Vol 2012 (2012)
Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical
Externí odkaz:
https://doaj.org/article/25827942427d4268bb33d6fb5b8cc237
Publikováno v:
Cardiology Research and Practice, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/bee86eb8c7d24fb98253eb8a919edc88
Single-Cell Analysis of ADSC Interactions with Fibroblasts and Endothelial Cells in Scleroderma Skin
Autor:
Butler, Marvin L. Frommer, Benjamin J. Langridge, Laura Awad, Sara Jasionowska, Christopher P. Denton, David J. Abraham, Jeries Abu-Hanna, Peter E. M.
Publikováno v:
Cells; Volume 12; Issue 13; Pages: 1784
Adipose-derived stem cells (ADSCs) as part of autologous fat grafting have anti-fibrotic and anti-inflammatory effects, but the exact mechanisms of action remain unknown. By simulating the interaction of ADSCs with fibroblasts and endothelial cells (