Zobrazeno 1 - 10
of 186
pro vyhledávání: '"David J Segal"'
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193818 (2018)
Prokaryotic Argonaute proteins (pAgos) have been proposed as an alternative to the CRISPR/Cas9 platform for gene editing. Although Argonaute from Natronobacterium gregoryi (NgAgo) was recently shown unable to cleave genomic DNA in mammalian cells, th
Externí odkaz:
https://doaj.org/article/5fe9074547764542bb6c960536bf0eff
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005410 (2015)
Dyskeratosis Congenita (DC) is a heritable multi-system disorder caused by abnormally short telomeres. Clinically diagnosed by the mucocutaneous symptoms, DC patients are at high risk for bone marrow failure, pulmonary fibrosis, and multiple types of
Externí odkaz:
https://doaj.org/article/4390749426e6402ab16d30e7681edb18
Autor:
Bonnie L Barrilleaux, Dana Burow, Sarah H Lockwood, Abigail Yu, David J Segal, Paul S Knoepfler
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101151 (2014)
The transcription factor Miz-1 can either activate or repress gene expression in concert with binding partners including the Myc oncoprotein. The genomic binding of Miz-1 includes both core promoters and more distal sites, but the preferred DNA bindi
Externí odkaz:
https://doaj.org/article/3c90ecefd8224e8186338daae5bde6b2
Autor:
David J Segal
Publikováno v:
eLife, Vol 2 (2013)
The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome engineering.
Externí odkaz:
https://doaj.org/article/d47233d3677b481985ecfc17d2bc61af
Autor:
Ulrika Beitnere, Brayan Vilanova-Cuevas, Sarah G. Christian, Clint Taylor, Elizabeth L. Berg, Nycole A. Copping, Scott V. Dindot, Jill L. Silverman, Mélanie G. Gareau, David J. Segal
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT A large subset of patients with Angelman syndrome (AS) suffer from concurrent gastrointestinal (GI) issues, including constipation, poor feeding, and reflux. AS is caused by the loss of ubiquitin ligase E3A (UBE3A) gene expression in the bra
Externí odkaz:
https://doaj.org/article/603c826aee6f48c298a9ce88f28aaa34
Autor:
David J. Segal
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/4b76b56c108247ca95782b28358a48db
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
An extensive arsenal of biosensing tools has been developed based on the clustered regularly interspaced short palindromic repeat (CRISPR) platform, including those that detect specific DNA sequences both in vitro and in live cells. To date, DNA imag
Externí odkaz:
https://doaj.org/article/20d965019e1643b1abd364af6fdf42ec
Autor:
Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and i
Externí odkaz:
https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
Autor:
Peter Deng, Julian A. N. M. Halmai, Ulrika Beitnere, David Cameron, Michele L. Martinez, Charles C. Lee, Jennifer J. Waldo, Krista Thongphanh, Anna Adhikari, Nycole Copping, Stela P. Petkova, Ruth D. Lee, Samantha Lock, Miranda Palomares, Henriette O’Geen, Jasmine Carter, Casiana E. Gonzalez, Fiona K. B. Buchanan, Johnathan D. Anderson, Fernando A. Fierro, Jan A. Nolta, Alice F. Tarantal, Jill L. Silverman, David J. Segal, Kyle D. Fink
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a
Externí odkaz:
https://doaj.org/article/467d6e2aab3844e6b89d37a65f30a120
Autor:
Henriette O’Geen, Ulrika Beitnere, Miranda S. Garcia, Anna Adhikari, David L. Cameron, Timothy A. Fenton, Nycole A. Copping, Peter Deng, Samantha Lock, Julian A.N.M. Halmai, Isaac J. Villegas, Jiajian Liu, Danhui Wang, Kyle D. Fink, Jill L. Silverman, David J. Segal
Publikováno v:
Molecular Therapy. 31:1088-1105