Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David J Rushton"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81031 (2013)
Optimal use of patient-derived, induced pluripotent stem cells for modeling neuronal diseases is crucially dependent upon the proper physiological maturation of derived neurons. As a strategy to develop defined differentiation protocols that optimize
Externí odkaz:
https://doaj.org/article/42295f54848f43cdaf8f8e2ed2c79e74
Autor:
Veronica J. Garcia, David J. Rushton, Colton M. Tom, Nicholas D. Allen, Paul J. Kemp, Clive N. Svendsen, Virginia B. Mattis
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Frontiers in Neuroscience
In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9680cbcb90fbe0bf42a0e3ec48aff790
https://orca.cardiff.ac.uk/id/eprint/124383/1/fnins-13-00669.pdf
https://orca.cardiff.ac.uk/id/eprint/124383/1/fnins-13-00669.pdf
Autor:
Paul J, Kemp, David J, Rushton, Polina L, Yarova, Christian, Schnell, Charlene, Geater, Jane M, Hancock, Annalena, Wieland, Alis, Hughes, Luned, Badder, Emma, Cope, Daniela, Riccardi, Andrew D, Randall, Jonathan T, Brown, Nicholas D, Allen, Vsevolod, Telezhkin
Publikováno v:
The Journal of physiology. 594(22)
Neurons differentiated from pluripotent stem cells using established neural culture conditions often exhibit functional deficits. Recently, we have developed enhanced media which both synchronize the neurogenesis of pluripotent stem cell‐derived ne
Publikováno v:
Biochemical Journal. 432:283-294
Notch signalling is an evolutionarily conserved pathway involved in cell-fate specification. The initiating event in this pathway is the binding of a Notch receptor to a DSL (Delta/Serrate/Lag-2) ligand on neighbouring cells triggering the proteolyti
Autor:
David J. Rushton, Joyce C. Lockhart
Publikováno v:
ChemInform. 23
Thiaalkane-bridge bis(benzimidazoles) varying both in the nature of the bridge and in the pendant groups attached to secondary nitrogen have been synthesised to assess metal selectivity in single and multiple phases. The single-phase studies (1H NMR,
Publikováno v:
ChemInform. 24
Two new series of azapropeller crowns have been synthesised and investigated. The aza-propeller crowns 7,10-ditosylaza-1,4,13,16-tetraoxacyclooctadecane, (9a) and 4,7,10-tritosylaza-1,13-dioxacyclo-pentadecane, (11) have been shown by X-ray structure
Autor:
Arie R. van Doorn, David J. Rushton, Wilma F. van Straaten-Nijenhuis, David N. Reinhoudt, Willem Verboom
Publikováno v:
Recueil des travaux chimiques des Pays-Bas, 111(10), 421-426. Royal Netherlands Chemical Society
Metallomacrocycle 2, possessing an immobilized Lewis‐acidic uranyl cation, was synthesized by reaction of aldehyde 9 with 1,2‐cis‐cyclohexanediamine in the presence of Ba2+ as a template cation and subsequent transmetallation with UO22+. Dockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1be1ec19c24364cb8822dffc9692c0
https://research.utwente.nl/en/publications/49a1c166-ac76-4364-b048-39a0098d458b
https://research.utwente.nl/en/publications/49a1c166-ac76-4364-b048-39a0098d458b
Publikováno v:
ChemInform. 21
A series of bis benzimidazole ligands, bridged by additional donor groups (ether, thioether) and with pendant carboxylic amide groups, was prepared. In three-phase transport experiments using one quadridentate ligand and metal nitrates, the sequence
Publikováno v:
Journal of the Chemical Society, Dalton Transactions. :209
Mixtures of cadmium salts and benzimidazoles have been examined by 1H, 13C and 113Cd NMR spectroscopy in dimethyl sulfoxide and in dimethyl sulfoxide–chloroform mixtures. Evidence of exchange processes both for cadmium entities and for ligand entit
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1259
Two new series of azapropeller crowns have been synthesised and investigated. The aza-propeller crowns 7,10-ditosylaza-1,4,13,16-tetraoxacyclooctadecane, (9a) and 4,7,10-tritosylaza-1,13-dioxacyclo-pentadecane, (11) have been shown by X-ray structure